Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 14, 2008, Pages 6707-6723

  Zhou, Dahui ^a   Zhou, Ping ^a   Evrard, Deborah A ^a   Meagher, Kristin ^a   Webb, Michael ^a   Harrison, Boyd L ^a   Huryn, Donna M ^a   Golembieski, Jeannette ^a   Hornby, Geoffrey A ^a   Schechter, Lee E ^a   Smith, Deborah L ^a   Andree, Terrance H ^a   Mewshaw, Richard E ^a  

^a PFIZER INC   (United States)

Author keywords

5 HT1A receptor; Serotonin transporter

Indexed keywords

5 (PIPERAZIN 1 YL)QUINOLINE DERIVATIVE; ANTIDEPRESSANT AGENT; ARYLPIPERAZINYL 4 YL CYCLOHEXYL INDOLE DERIVATIVES; SEROTONIN 1A ANTAGONIST; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIDEPRESSIVE AGENTS; CYCLOHEXYLAMINES; HUMANS; INDOLES; PIPERAZINES; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 47349085101     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.05.075     Document Type: Article

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