Structural basis for specific substrate recognition by the chloroplast signal recognition particle protein cpSRP43

Science

Volumn 321, Issue 5886, 2008, Pages 253-256

  Stengel, Katharina F ^a   Holdermann, Iris ^a   Cain, Peter ^b   Robinson, Colin ^b   Wild, Klemens ^a   Sinning, Irmgard ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; MEMBRANE PROTEIN; PROTEIN SRP54;

CHLOROPLAST; CYTOPLASM; PROTEIN; SIGNAL;

ARABIDOPSIS; ARTICLE; CHLOROPLAST; CRYSTAL STRUCTURE; CYTOPLASM; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANKYRIN REPEAT; ARABIDOPSIS; ARABIDOPSIS PROTEINS; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; HYDROPHOBICITY; LIGHT-HARVESTING PROTEIN COMPLEXES; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RNA, PLANT; SIGNAL RECOGNITION PARTICLE; THYLAKOIDS;

EID: 47249160767     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1158640     Document Type: Article

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36. We thank the European Synchrotron Radiation Facility (ESRF, Grenoble, France) for access to the beamlines and their staff for assistance during data collection. We are grateful to V. Rybin [European Molecular Biology Laboratory (EMBL), Heidelberg, Germany] for initial ITC measurements; N. Hoffman for the original cpSRP clones; K. teKaat, M. Groves, and U. Dürrwang for their contributions; and A. Hendricks for expert technical assistance. We thank M. Sattler (EMBL, Heidelberg) for stimulating discussions and NMR experiments and B. Dobberstein (ZMBH, University of Heidelberg, Germany) for helpful comments on the manuscript. This work was supported by the Deutsche Forschungsgemeinschaft (SFB638). The coordinates for the structures have been deposited in the Protein Data Bank under the accession codes 3DEO and 3DEP.