Tryptophan catabolites in mesenteric lymph may contribute to pancreatitis-associated organ failure

British Journal of Surgery

Volumn 95, Issue 7, 2008, Pages 855-867

  Mole, D J ^a,c,f,g   McFerran, N V ^b   Collett, G ^c,d   O'Neill, C ^c   Diamond, T ^c   Garden, O J ^a   Kylanpaa, L ^e   Repo, H ^e   Deitch, E A ^f  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b School of Biological Sciences

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF HELSINKI   (Finland)

^f RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^g ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYKYNURENINE; TRYPTOPHAN; KYNURENINE; PROTEOME;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTIFICIAL VENTILATION; CATABOLISM; COHORT ANALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; EXPERIMENTAL RAT; HEMODIALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MESENTERY LYMPH NODE; MULTIPLE ORGAN FAILURE; NONHUMAN; PRIORITY JOURNAL; RAT; ACUTE DISEASE; ANIMAL; ARTICLE; LIGATION; LYMPH; MESENTERY; METABOLISM; NEUTROPHIL; PANCREATITIS; RESPIRATORY BURST; SPRAGUE DAWLEY RAT;

ACUTE DISEASE; ANIMALS; KYNURENINE; LIGATION; LYMPH; MALE; MESENTERY; MULTIPLE ORGAN FAILURE; NEUTROPHILS; PANCREATITIS; PROTEOME; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY BURST; TRYPTOPHAN;

EID: 47249090374     PISSN: 00071323     EISSN: 13652168     Source Type: Journal    
DOI: 10.1002/bjs.6112     Document Type: Conference Paper

References (32)

1. Steinberg W, Tenner S. Acute pancreatitis. N Engl J Med 1994; 330: 1198-1210.
2. Johnson CD, Abu-Hilal M. Persistent organ failure during the first week as a marker of fatal outcome in acute pancreatitis. Gut 2004; 53: 1340-1344.
3. Beutler B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 2004; 430: 257-263.
4. Steer ML. Primary intracellular events in pancreatitis. In Acute Pancreatitis: Novel Concepts in Biology and Therapy, Buchler MW, Uhl W, Friess H, Malfertheiner P (eds). Blackwell Science: Berlin, 1999; 3-12.
5. Hynninen M, Valtonen M, Markkanen H, Vaara M, Kuusela P, Jousela I et al. Intramucosal pH and endotoxin and cytokine release in severe acute pancreatitis. Shock 2000; 13: 79-82.
6. Moore FA, Feliciano DV, Andrassy RJ, McArdle AH, Booth FV, Morgenstein-Wagner TB et al. Early enteral feeding, compared with parenteral, reduces postoperative septic complications. The results of a meta-analysis. Ann Surg 1992; 216: 172-183.
7. McKay CJ, Evans S, Sinclair M, Carter CR, Imrie CW. High early mortality rate from acute pancreatitis in Scodand, 1984-1995. Br J Surg 1999; 86: 1302-1305.
8. Deitch EA, Feketeova E, Adams JM, Forsythe RM, Xu DZ, Itagaki K et al. Lymph from a primate baboon trauma hemorrhagic shock model activates human neutrophils. Shock 2006; 25: 460-463.
9. Adams CAJr, Sambol JT, Xu DZ, Lu Q, Granger DN, Deitch EA. Hemorrhagic shock induced up-regulation of P-selectin expression is mediated by factors in mesenteric lymph and blunted by mesenteric lymph duct interruption. J Trauma 2001; 51: 625-631.
10. Magnotti LJ, Upperman JS, Xu DZ, Lu Q, Deitch EA. Gut-derived mesenteric lymph but not portal blood increases endothelial cell permeability and promotes lung injury after hemorrhagic shock. Ann Surg 1998; 228: 518-527.
11. Deitch EA, Xu D, Kaise VL. Role of the gut in die development of injury- and shock induced SIRS and MODS: die gut-lymph hypothesis, a review. Front Biosci 2006; 11: 520-528.
12. Closa D, Sabater L, Femandez-Cruz L, Prats N, Gelpi E, Rosello-Catafau J. Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver. Ann Surg 1999; 229: 230-236.
13. Hirota M, Inoue K, Kimura Y, Mizumoto T, Kuwata K, Ohmuraya M et al. Non-occlusive mesenteric ischemia and its associated intestinal gangrene in acute pancreatitis. Pancreatology 2003; 3: 316-322.
14. Rahman SH, Ammori BJ, Holmfield J, Larvin M, McMahon MJ. Intestinal hypoperfusion contributes to gut barrier failure in severe acute pancreatitis. J Gastrointest Surg 2003;7:35-36.
15. Pellegrin K, Neurauter G, Wirleitner B, Fleming AW, Peterson VM, Fuchs D. Enhanced enzymatic degradation of tryptophan by indoleamine 2,3-dioxygenase contributes to the tryptophan-deficient state seen after major trauma. Shock 2005;23:209-215.
16. Munn DH, Sharma MD, Lee JR, Jhaver KG, Johnson TS, Keskin DB et al. Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 2002; 297: 1867-1870.
17. Mole DJ, Taylor MA, McFerran NV, Diamond T. The isolated perfused liver response to a 'second hit' of portal endotoxin during severe acute pancreatitis. Pancreatology 2005; 5: 475-485.
18. Schmidt J, Rattner DW, Lewandrowski K, Compton CC, Mandavilli U, Knoefel WT et al. A better model of acute pancreatitis for evaluating therapy. Ann Surg 1992; 215: 44-56.
19. Anderson BO, Brown JM, Shanley PF, Bensard DD, Harken AH. Marginating neutrophils are reversibly adherent to normal lung endothelium. Surgery 1991; 109: 51-61.
20. Berezina TL, Zaets SB, Mole DJ, Spolarics Z, Deitch EA Machiedo GW. Mesenteric lymph duct ligation decreases red blood cell alterations caused by acute pancreatitis. Am J Surg 2005; 190: 800-804.
21. Yong S, Lau S. Rapid separation of tryptophan, kynurenines, and indoles using reversed-phase high-performance liquid chromatography. J Chromatogr 1979; 175: 343-346.
22. Rnaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985; 13: 818-829.
23. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 1995; 23: 1638-1652.
24. Bradley EL III. A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. .Aruh Surg 1993; 128: 586-590.
25. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 1998; 95: 14 863-14 868.
26. Johnson CD, Kingsnorth AN, Imrie CW, McMahon MJ, Neoptolemos JP, McKay C et al. Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis. Gut 2001; 48: 62-69.
27. Belladonna ML, Grohmann U, Guidetti P, Volpi C, Bianchi R, Fioretti MC et al. Kynurenine pathway enzymes in dendritic cells initiate tolerogenesis in the absence of functional IDO. J Immunol 2006; 177: 130-137.
28. Mellor AL, Keskin DB, Johnson T, Chandler P, Munn DH. Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses. J Immunol 2002; 168: 3771-3776.
29. Munn DH, Shafizadeh E, Attwood JT, Bondarev I, Pashine A, Mellor AL. Inhibition of T cell proliferation by macrophage tryptophan catabolism. J Exp Med 1999; 189: 1363-1372.
30. Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 1998; 281: 1191-1193.
31. Kristiansen M, Graversen JH, Jacobsen C, Sonne O, Hoffman HJ, Law SK et al. Identification of the haemoglobin scavenger receptor. Nature 2001; 409: 198-201.
32. Taylor PR, Martinez-Pomares L, Stacey M, Lin HH, Brown GD, Gordon S. Macrophage receptors and immune recognition. Annu Rev Immunol 2005; 23: 901-944.