Isosteric exchange of the acylsulfonamide moiety in Abbott's Bcl-XL protein interaction antagonist

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 14, 2008, Pages 4115-4117

  Dömling, Alexander ^a,b   Antuch, Walfrido ^b   Beck, Barbara ^b   Schauer Vukašinović, Vesna ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b Morphochem AG   (Germany)

Author keywords

Apoptosis; Bcl; Cancer; Isocyanide; Multi component reaction; Protein protein interaction; Structure based design

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ACYLSULFONAMIDE DERIVATIVE; AMIDE; AROMATIC COMPOUND; BCL 2 PROTEIN INHIBITOR; ISOSTERE; PEPTIDE LIBRARY; PROTEIN BCL XL; SULFONAMIDE; WO 2002024636;

ARTICLE; CANCER INHIBITION; CHEMICAL REACTION KINETICS; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; GENE DISRUPTION; INHIBITION KINETICS; MOLECULAR MODEL; NONHUMAN; PROTEIN PROTEIN INTERACTION; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; UGI REACTION;

AMIDES; APOPTOSIS; BCL-X PROTEIN; CHEMISTRY, PHARMACEUTICAL; CYANIDES; DRUG DESIGN; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEOPLASMS; PEPTIDES; PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 47149111580     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.096     Document Type: Article

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