Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38α mitogen-activated protein kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 14, 2008, Pages 4006-4010

  Kim, Dae Kee ^a   Lim, Jin Hwi ^a   Lee, Jung A ^a   Dewang, Purushottam M ^a  

^a Ewha Womans University   (South Korea)

Author keywords

Antiinflammatory; p38 MAP kinase inhibitors; Trisubstituted imidazole

Indexed keywords

IMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR;

ARTICLE; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; INFLAMMATION; ISOMER; NUCLEAR OVERHAUSER EFFECT; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANTI-INFLAMMATORY AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MAP KINASE SIGNALING SYSTEM; MODELS, CHEMICAL; MOLECULAR STRUCTURE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 47149103821     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.06.007     Document Type: Article

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