Aranciamycin analogs generated by combinatorial biosynthesis show improved antitumor activity

Applied Microbiology and Biotechnology

Volumn 80, Issue 1, 2008, Pages 15-19

  Luzhetskyy, Andriy ^a   Hoffmann, Jens ^c   Pelzer, Stefan ^b   Wohlert, Sven Eric ^b   Vente, Andreas ^b   Bechthold, Andreas ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b MerLion Pharmaceuticals GmbH   (Germany)

^c BAYER PHARMA AG   (Germany)

Author keywords

Anthracyclines; Anticancer activity; Aranciamycin; Combinatorial biosynthesis

Indexed keywords

ARSENIC COMPOUNDS; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY;

ANTHRACYCLINES; ANTI-TUMOR ACTIVITIES; ANTICANCER ACTIVITY; ARANCIAMYCIN; BIOSYNTHETIC GENES; COMBINATORIAL BIOSYNTHESIS; NOVEL COMPOUNDS;

CHLORINE COMPOUNDS;

ANTHRACYCLINE DERIVATIVE; ARANCIAMYCIN; HYDROXYL GROUP;

ANTIBIOTICS; BACTERIUM; BIOACTIVITY; GENE EXPRESSION; MICROBIAL ACTIVITY; TUMOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; BIOSYNTHESIS; CELL STRAIN MCF 7; CLONING; GENE CLUSTER; HUMAN; HUMAN CELL; HYDROXYLATION; STREPTOMYCES; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANTHRACYCLINES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; GENETIC ENGINEERING; HUMANS; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; STREPTOMYCES; STRUCTURE-ACTIVITY RELATIONSHIP;

STREPTOMYCES DIASTATOCHROMOGENES;

EID: 47149102679     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-008-1515-1     Document Type: Article

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