Micronization of gemfibrozil by reactive precipitation process

International Journal of Pharmaceutics

Volumn 360, Issue 1-2, 2008, Pages 58-64

  Huang, Qiao Ping ^a   Wang, Jie Xin ^a   Chen, Gui Zhi ^a   Shen, Zhi Gang ^a,b   Chen, Jian Feng ^a   Yun, Jimmy ^b  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b NanoMaterials Technology Pte Ltd   (Singapore)

Author keywords

Gemfibrozil; Poorly water soluble drug; Reactive precipitation; Ultrafine powder

Indexed keywords

GEMFIBROZIL; METHYLCELLULOSE; SODIUM HYDROXIDE; SULFURIC ACID;

ARTICLE; DRUG SOLUBILITY; DRUG STRUCTURE; INFRARED SPECTROSCOPY; PARTICLE SIZE; PRECIPITATION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; STRUCTURE ANALYSIS; X RAY DIFFRACTION;

ANTILIPEMIC AGENTS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DESICCATION; EXCIPIENTS; GEMFIBROZIL; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POWDERS; SODIUM HYDROXIDE; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SULFURIC ACIDS; X-RAY DIFFRACTION;

EID: 47049119798     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.04.026     Document Type: Article

References (27)

1. Ammazzalorso A., Amoroso R., Bettoni G., Chiarini M., Filippis B.D., Fantacuzzi M., Giampietro L., Maccallini C., and Tricca M.L. Enantiomeric separation of gemfibrozil chiral analogues by capillary electrophoresis with heptakis (2,3,6-tri-O-methyl)-β-cyclodextrin as chiral selector. J. Chromatogr. A 1088 (2005) 110-120
2. Dirksen J.A., and Ring T.A. Fundamentals of crystallization: kinetic effects on particle size distributions and morphology. Chem. Eng. Sci. 46 (1991) 2389-2427
3. Drooge D.J.V., Hinrichs W.L.J., and Frijlink H.W. Anomalous dissolution behaveiour of tablets prepared from sugar glass-based solid dispersions. J. Controlled Release 97 (2004) 441-452
4. Ghebre-Sellassie, I., Fawzi, M.B., 1994. Gemfibrozil formulations. US Patent 5,281,421, January 25.
5. Gupta R.B., and Kompella U.B. Nanoparticle Technology for Drug Delivery. first ed. (2006), Taylor & Francis Group, New York pp. 23-36
6. Horn D., and Rieger J. Organic nanoparticles in the aqueous phase-theory, experiment, and use. Angew. Chem. Int. Ed. 40 (2001) 4330-4361
7. Javadzadeh Y., Jafari-Navimipour B., and Nokhodchi A. Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine). Int. J. Pharm. 341 (2007) 26-34
8. Keck C.M., and Müller R.H. Drug nanocrystals of poorly soluble drugs produced by high pressure homogenization. Eur. J. Pharm. Biopharm. 62 (2006) 3-16
9. Kharb V., Bhatia M., Dureja H., and Kaushik D. Nanoparticle technology for the delivery of poorly water-soluble drugs. Pharm. Technol. 2 (2006) 82-92
10. Kipp J.E. The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs. Int. J. Pharm. 284 (2004) 109-122
11. Kocbek P., Baumartner S., and Kristl J. Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly soluble drugs. Int. J. Pharm. 312 (2006) 179-186
12. Kuentz M., Egloff P., and Röthlisberger D. A technical easibility study of surfactant-free drug suspensions utilizing octenyl uccinate-modified starches. Eur. J. Pharm. Biopharm. 63 (2006) 37-43
13. Löbenberg R., and Amidon G.L. Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards. Eur. J. Pharm. Biopharm. 50 (2000) 3-12
14. Martinac A., Filipovic-Grcic J., Barbaric M., Zorc B., Voinovich D., and Jalšenjak I. Gemfibrozil encapsulation and release from microspheres and macromoleculear conjugates. Eur. J. Pharm. Sci. 17 (2002) 207-216
15. Mosharraf M., and NyatrÖm C. The effect of particle size and shape on the surface specific dissolution rate of microsized practically insoluble drugs. Int. J. Pharm. 122 (1995) 35-47
16. Muhrer G., Meier U., Fusaro F., Albano S., and Mazzotti M. Use of compressed gas precipitation to enhance the dissolution behavior of a poorly water-soluble drug: generation of drug microparticles and drug-polymer solid dispersions. Int. J. Pharm. 308 (2006) 69-83
17. Müller R.H., and Peters K. Nanosuspensions for the formulation of poorly soluble drugs I. Preparation by a size-reduction technique. Int. J. Pharm. 160 (1998) 229-237
18. Oda M., Saitoh H., Kobayashi M., and Aungst B.J. β-Cyclodextrin as a suitable solubilizing agent for in situ absorption study of poorly water-soluble drugs. Int. J. Pharm. 280 (2004) 95-102
19. Rabinow B.E. Nanosuspensions in drug delivery. Drug Discov. 3 (2004) 785-796
20. Rasenack N., Hartenhauer H., and Müller B.W. Microcrystals for dissolution rate enhancement of poorly water-soluble drugs. Int. J. Pharm. 254 (2003) 137-145
21. Rasenack N., Steckel H., and Müller B.W. Preparation of microcrystals by in situ micronization. Powder Technol. 143-144 (2004) 291-296
22. Rogers T.L., Nelsen A.C., Hu J.H., Brown J.N., Sarkari M., Young T.J., Johnston K.P., and Williams III R.O. A novel particle engineering technology to enhance dissolution of pooly water soluble drugs: spray-freezing into liquid. Eur. J. Pharm. Biopharm. 54 (2002) 271-280
23. Sarkari M., Brown J., Chen X.X., Swinnea S., Williams III R.O., and Johnston K.P. Enhanced drug dissolution using evaporative precipitation into aqueous solution. Int. J. Pharm. 243 (2002) 17-31
24. Terayama H., Inada K., Nakayama H., Yasueda S., and Esumi K. Preparation of stable aqueous suspension of a hydrophobic drug with polymers. Colloids Surf. B: Biointerface 39 (2004) 159-164
25. Wang Z., Chen J.F., Le Y., Shen Z.G., and Yun J. Preparation of ultrafine Beclomethasone Dipropionate drug powder by antisolvent precipitation. Ind. Eng. Chem. Res. 46 (2007) 4839-4845
26. Zhang J.Y., Shen Z.G., Zhong J., Hu T.T., Chen J.F., Ma Z.Q., and Yun J. Preparation of amorphous cefuroxime axetil nanoparticles by controlled nanoprecipitation method without surfactants. Int. J. Pharm. 323 (2006) 153-160
27. Zhong J., Shen Z.G., Yang Y., and Chen J.F. Preparation and characterization of uniform nanosized cephradine by combination of reactive precipitation and liquid anti-solvent precipitation under high gravity environment. Int. J. Pharm. 301 (2005) 286-293