Evidence that AphB, essential for the virulence of vibrio vulnificus, is a global regulator

Journal of Bacteriology

Volumn 190, Issue 10, 2008, Pages 3768-3773

  Jeong, Hee Gon ^a   Choi, Sang Ho ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

VIRULENCE FACTOR; APHB PROTEIN, VIBRIO CHOLERAE; BACTERIAL PROTEIN; TRANSACTIVATOR PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BACTERIUM MUTANT; CELL ADHESION; CELL MOTILITY; GASTROINTESTINAL INFECTION; GENE CONTROL; GENE EXPRESSION; GENE SEQUENCE; HOST CELL; MICROARRAY ANALYSIS; PATHOGENESIS; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; VIBRIO VULNIFICUS; VIRULENCE; BACTERIUM ADHERENCE; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; GRAM NEGATIVE INFECTION; METABOLISM; PATHOGENICITY; PHYSIOLOGY; REGULATOR GENE;

VIBRIO VULNIFICUS;

BACTERIAL ADHESION; BACTERIAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, REGULATOR; MICROARRAY ANALYSIS; TRANS-ACTIVATORS; VIBRIO INFECTIONS; VIBRIO VULNIFICUS;

EID: 47049101007     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.00058-08     Document Type: Article

References (32)

1. Actis, L. A., M. E. Tolmasky, L. M. Crosa, and J. H. Crosa. 1995. Characterization and regulation of the expression of FatB, an iron transport protein encoded by the pJM1 virulence plasmid. Mol. Microbiol. 17: 197-204.
2. Choi, J. J., D. W. Shin, D., and S. R. Ryu. 2007. Implication of quorum sensing in Salmonella enterica serovar Typhimurium virulence: the luxS gene is necessary for expression of genes in pathogenicity island 1. Infect. Immun. 75: 4885-4890.
3. D'Argenio, D. A., and S. I. Miller. 2004. Cyclic di-GMP as a bacterial second messenger. Microbiology 150: 2497-2502.
4. DiRita, V. J., C. Parsot, G. Jander, and J. J. Mekalanos. 1991. Regulatory cascade controls virulence in Vibrio cholerae. Proc. Natl. Acad. Sci. USA 88: 5403-5407.
5. Fink, R. C., M. R. Evans, S. Porwollik, A. Vazquez-Torres, J. Jones-Carson, B. Troxell, S. J. Libby, M. McClelland, and H. M. Hassan. 2007. FNR is a global regulator of virulence and anaerobic metabolism in Salmonella enterica serovar Typhimurium (ATCC 14028s). J. Bacteriol. 189: 2262-2273.
6. Goo, S. Y., H. J. Lee, W. H. Kim, K. L. Han, D. K. Park, H. J. Lee, S. M. Kim, K. S. Kim, K. H. Lee, and S. J. Park. 2006. Identification of OmpU of Vibrio vulnificus as a fibronectin-binding protein and its role in bacterial pathogenesis. Infect. Immun. 74: 5586-5594.
7. Häse, C. C., and J. J. Mekalanos. 1998. TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae. Proc. Natl. Acad. Sci. USA 95: 730-734.
8. Herrington, D. A., R. H. Hall, G. Losonsky, J. J. Mekalanos, R. K. Taylor, and M. M. Levine. 1988. Toxin, toxin-coregulated pili, and the toxR regulon are essential for Vibrio cholerae pathogenesis in humans. J. Exp. Med. 168: 1487-1492.
9. Hondorp, E. R., and K. S. McIver. 2007. The Mga virulence regulon: infection where the grass is greener. Mol. Microbiol. 66: 1056-1065.
10. Kaper, J. B., J. R. Morris, Jr., and M. M. Levine. 1995. Cholera. Clin. Microbiol. Rev. 8: 48-86.
11. Kovacikova, G., and K. Skorupski. 1999. A Vibrio cholerae LysR homolog, AphB, cooperates with AphA at the tcpPH promoter to activate expression of the ToxR virulence cascade. J. Bacteriol. 181: 4250-4256.
12. Kovacikova, G., and K. Skorupski. 2000. Differential activation of the tcpPH promoter by AphB determines biotype specificity of virulence gene expression in Vibrio cholerae. J. Bacteriol. 182: 3228-3238.
13. Kovacikova, G., and K. Skorupski. 2001. Overlapping binding sites for the virulence gene regulators AphA, AphB and cAMP-CRP at the Vibrio cholerae tcpPH promoter. Mol. Microbiol. 41: 393-407.
14. Kovacikova, G., and K. Skorupski. 2002. Binding site requirements of the virulence gene regulator AphB: differential affinities for the Vibrio cholerae classical and El Tor tcpPH promoters. Mol. Microbiol. 44: 533-547.
15. Lee, J. H., M. W. Kim, B. S. Kim, S. M. Kim, B. C. Lee, T. S. Kim, and S. H. Choi. 2007. Identification and characterization of the Vibrio vulnificus rtxA essential for cytotoxicity in vitro and virulence in mice. J. Microbiol. 45: 146-152.
16. Lim, M. S., M. H. Lee, J. H. Lee, H. M. Ju, N. Y. Park, H. S. Jeong, J. E. Rhee, and S. H. Choi. 2005. Identification and characterization of the Vibrio vulnificus malPQ operon. J. Microbiol. Biotechnol. 15: 616-625.
17. Litwin, C. M., and B. L. Byrne. 1998. Cloning and characterization of an outer membrane protein of Vibrio vulnificus required for heme utilization: regulation of expression and determination of the gene sequence. Infect. Immun. 66: 3134-3141.
18. Litwin, C. M., T. W. Rayback, and J. Skinner. 1996. Role of catechol siderophore synthesis in Vibrio vulnificus virulence. Infect. Immun. 64: 2834-2838.
19. Martin, R. G., and J. L. Rosner. 2001. The AraC transcriptional activators. Curr. Opin. Microbiol. 4: 132-137.
20. Mekalanos, J. J. 1992. Environmental signals controlling expression of virulence determinants in bacteria. J. Bacteriol. 174: 1-7.
21. Miller, J. F., J. J. Mekalanos, and S. Falkow. 1989. Coordinate regulation and sensory transduction in the control of bacterial virulence. Science 243: 916-922.
22. Miller, M. B., and B. L. Bassler. 2001. Quorum sensing in bacteria. Annu. Rev. Microbiol. 55: 165-199.
23. Oliver, J. D., J. E. Wear, M. B. Thomas, M. Warner, and K. Linder. 1986. Production of extracellular enzymes and cytotoxicity by Vibrio vulnificus. Diagn. Microbiol. Infect. Dis. 5: 99-111.
24. Ottemann, K. M., and J. F. Miller. 1997. Role for motility in bacterial-host interactions. Mol. Microbiol. 24: 1109-1117.
25. Paranjpye, R. N., J. C. Lara, J. C. Pepe, C. M. Pepe, and M. S. Strom. 1998. The type IV leader peptidase/N-methyltransferase of Vibrio vulnificus controls factors required for adherence to HEp-2 cells and virulence in iron-overloaded mice. Infect. Immun. 66: 5659-5668.
26. Paranjpye, R. N., and M. S. Strom. 2005. A Vibrio vulnificus type IV pilin contributes to biofilm formation, adherence to epithelial cells, and virulence. Infect. Immun. 73: 1411-1422.
27. Park, N. Y., J. H. Lee, M. W. Kim, H. G. Jeong, B. C. Lee, T. S. Kim, and S. H. Choi. 2006. Identification of Vibrio vulnificus wbpP gene and evaluation of its role in virulence. Infect. Immun. 74: 721-728.
28. Rhee, J. E., H. G. Jeong, J. H. Lee, and S. H. Choi. 2006. AphB influences acid tolerance of Vibrio vulnificus by activating expression of the positive regulator CadC. J. Bacteriol. 188: 6490-6497.
29. Rhee, J. E., J. H. Rhee, P. Y. Ryu, and S. H. Choi. 2002. Identification of the cadBA operon from Vibrio vulnificus and its influence on survival to acid stress. FEMS Microbiol. Lett. 208: 245-251.
30. Rhee, J. E., K. S. Kim, and S. H. Choi. 2005. CadC activates pH-dependent expression of the Vibro vulnificus cadBA operon at a distance through direct binding to an upstream region. J. Bacteriol. 187: 7870-7875.
31. Sepp, A., R. M. Binns, and R. I. Lechler. 1996. Improved protocol for colorimetric detection of complement-mediated cytotoxicity based on the measurement of cytoplasmic lactate dehydrogenase activity. J. Immunol. Methods 196: 175-180.
32. Wright, A. C., J. G. Morris, Jr., D. R. Maneval, Jr., K. Richardson, and J. B. Kaper. 1985. Cloning of the cytotoxin-hemolysin gene of Vibrio vulnificus. Infect. Immun. 50: 922-924.