Massive interleukin-12-induced interferon-γ production by interleukin-15-stimulated lamina propria lymphocytes followed by down-regulation of the interleukin-12 receptor

Immunology

Volumn 124, Issue 4, 2008, Pages 453-460

  Ebert, Ellen C ^a,b   Jabri, Bana ^c  

^a UMDNJ Robert Wood Johnson Medical School ^*  (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

Interferon ; Interleukin 12; Interleukin 15; Lamina propria lymphocytes

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 12 RECEPTOR BETA1; INTERLEUKIN 12 RECEPTOR BETA2; INTERLEUKIN 15; STAT1 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; STAT5 PROTEIN; T LYMPHOCYTE RECEPTOR;

ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOFLUORESCENCE TEST; INTESTINE; LAMINA PROPRIA; LAMINA PROPRIA LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; STIMULUS RESPONSE; T LYMPHOCYTE; UPREGULATION;

CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; DOWN-REGULATION; HUMANS; IMMUNITY, MUCOSAL; INTERFERON-GAMMA; INTERLEUKIN-12; INTERLEUKIN-15; INTESTINAL MUCOSA; JEJUNUM; MUCOUS MEMBRANE; PHOSPHORYLATION; RECEPTORS, INTERLEUKIN-12; STAT TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 46949093524     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2007.02796.x     Document Type: Article

References (36)

1. Maruo S, Toyo-oka K, Oh-hora M et al. IL-12 produced by antigen-presenting cells induces IL-2-independent proliferation of T helper cell clones. J Immunol 1996 156 : 1748 55.
2. Park AY, Hondowicz BD, Scott P. IL-12 is required to maintain a Th1 response during Leishmania major infection. J Immunol 2000 165 : 896 902.
3. Jouanguy E, Doffinger R, Dupuis S, Pallier A, Altare F, Casanova JL. IL-12 and IFNγ in host defense against mycobacteria and Salmonella in mice and men. Curr Opin Immunol 1999 11 : 346 51.
4. Bacon CM, McVicar DW, Ortaldo JR, Rees RC, O'Shea JJ, Johnston JA. Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J Exp Med 1995 181 : 399 404.
5. Bacon CM, Petricoin ER, Ortaldo JR et al. Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc Natl Acad Sci U S A 1995 92 : 7307 11.
6. Jacobson NG, Szabo SJ, Weber-Nordt RM, Zhong Z, Schreiber RD, Darnell JE, Murphy KM. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (STAT)3 and STAT4. J Exp Med 1995 181 : 1755 62.
7. Gollob JA, Murphy EA, Mahajan S, Schnipper CP, Ritz J, Frank DA. Altered interleukin-12 responsiveness in Th2 and Th2 cells is associated with the differential activation of STAT5 and STAT1. Blood 1998 91 : 1341 54.
8. + T cells in the absence of TCR ligation. J Immunol 1998 161 : 3408 15.
9. Liu Z, Geboes K, Colpaert S, D'Haens GR, Rutgeerts P, Ceuppens JL. IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production. J Immunol 2000 164 : 3608 15.
10. + T cell responsiveness to antigen. J Immunol 1998 161 : 2141 50.
11. Doherty TM, Seder RA, Sher A. Induction and regulation of IL-15 expression in murine macrophages. J Immunol 1996 156 : 735 41.
12. Johnston JA, Kawamura M, Kirken RA et al. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 1994 370 : 151 3.
13. Johnston JA, Bacon CM, Finbloom DS et al. Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. Proc Natl Acad Sci U S A 1995 92 : 8705 9.
14. Gollob JA, Schnipper CP, Murphy EA, Ritz J, Frank DA. The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation. J Immunol 1999 162 : 4472 81.
15. Flesch EEA, Kaufmann SHE. Differential induction of IL-12 synthesis by Mycobacterium bovis BCG and Listeria monocytogenes. Res Immunol 1996 146 : 520.
16. Kennedy M, Picha KS, Shanebeck KD, Anderson DM, Grabstein KH. Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones. Eur J Immunol 1994 24 : 2271.
17. Musso T, Calosso L, Zucca M et al. Human monocytes constitutively express membrane-bound, biologically active, and interferon-γ-up-regulated interleukin 15. Blood 1999 93 : 3531 9.
18. Chang JT, Shevach EM, Segal BM. Regulation of interleukin-12 receptor β2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells. J Exp Med 1999 189 : 969 78.
19. Feurerer M, Eulenburg K, Loddenkemper C, Hamann A, Huehn J. Self-limitation of Th1-mediated inflammation by IFN-γ. J Immunol 2006 176 : 2857 63.
20. DeMaria R, Fais S, Silvestri M, Frati L, Pallone F, Santoni A, Testi R. Continuous in vivo activation and transient hyporesponsiveness to TCR/CD3 triggering of human gut lamina propria lymphocytes. Eur J Immunol 1993 23 : 3204 8.
21. Monteleone G, Parrello T, Luzza F, Pallone F. Response of human intestinal lamina propria T lymphocytes to IL-12: additive effects of IL-15 and 7. Gut 1998 43 : 620 8.
22. Okazawa A, Kanai T, Watanabe M et al. Th1-mediated intestinal inflammation in Crohn's disease may be induced by activation of lamina propria lymphocytes through synergistic stimulation of IL-12 and IL-18 without T cell receptor engagement. Am J Gastroenterol 2002 97 : 3108 17.
23. Kanai T, Watanabe M, Okazawa A et al. Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease. Gastroenterology 2000 119 : 1514 23.
24. Monteleone G, Biancone L, Marasco R, Morrone G, Marasco O, Luzza F, Pallone F. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 1997 112 : 1169 78.
25. Parrello T, Monteleone G, Cucchiara S, Monteleone I, Sebkova L, Doldo P, Luzza F, Pallone F. Up-regulation of the IL-12 receptor β2 chain in Crohn's disease. J Immunol 2000 165 : 7234 9.
26. + T cells requires CD40-CD40 ligand interactions for a sustained increase in mucosal IL-12. J Immunol 2000 165 : 2173 82.
27. Ebert EC. CD2 activation of human lamina propria lymphocytes reduces CD3 responsiveness. Immunology 2005 117 : 71 7.
28. Meuer SC, Hussey RE, Fabbi M et al. An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein. Cell 1984 36 : 897 906.
29. Yoshimoto T, Takeda K, Tanaka T, Ohkusu K, Kashiwamura S-I, Okamura H, Akira S, Nakanishi K. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFNγ production. J Immunol 1998 161 : 3400 7.
30. Targan SR, Deem RL, Liu M, Wang S, Nel A. Definition of a lamina propria T cell responsive state: enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway. J Immunol 1995 154 : 664 75.
31. Ebert EC. Interleukin 15 is a potent stimulant of intraepithelial lymphocytes. Gastroenterology 1998 115 : 1439 45.
32. Gollob JA, Li J, Kawasaki H, Daley JF, Groves C, Reinherz EL, Ritz J. Molecular interaction between CD58 and CD2 counter-receptors mediates the ability of monocytes to augment T cell activation by IL-12. J Immunol 1996 157 : 1886 93.
33. Akira S. The role of IL-18 in innate immunity. Curr Opin Immunol 2000 12 : 59 63.
34. Chang JT, Segal BM, Nakanishi K, Okamura H, Shevach EM. The costimulatory effect of IL-18 on the induction of antigen-specific IFNγ production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor β2 subunit. Eur J Immunol 2000 30 : 1113 9.
35. Braunstein J, Qiao L, Autschbach F, Schurmann G, Meuer S. T cells of the human intestinal lamina propria are high producers of interleukin-10. Gut 1997 41 : 215 20.
36. Madsen KL, Lewis SA, Tavernini MM, Hibbard J, Fedorak RN. Interleukin 10 prevents cytokine-induced disruption of T84 monolayer barrier integrity and limits chloride secretion. Gastroenterology 1997 113 : 151 9.