Hydrolytic reactivity trends among potential prodrugs of the O 2-glycosylated diazeniumdiolate family. Targeting nitric oxide to macrophages for antileishmanial activity

Journal of Medicinal Chemistry

Volumn 51, Issue 13, 2008, Pages 3961-3970

  Valdez, Carlos A ^a   Saavedra, Joseph E ^b   Showalter, Brett M ^a   Davies, Keith M ^c   Wilde, Thomas C ^a   Citro, Michael L ^b   Barchi Jr , Joseph J ^a   Deschamps, Jeffrey R ^d   Parrish, Damon ^d   El Gayar, Stefan ^e,g   Schleicher, Ulrike ^e,f   Bogdan, Christian ^e,f   Keefer, Larry K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c GEORGE MASON UNIVERSITY   (United States)

^d NAVAL RESEARCH LABORATORY   (United States)

^e UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^f UNIVERSITY OF FREIBURG   (Germany)

^g UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 O (BETA DEXTRO N ACETYLGLUCOSAMINYL) 1 (PYRROLIDIN 1 YL)DIAZEN 1 IUM 1,2 DIOLATE; 2 O (N ACETYL BETA DEXTRO GLUCOSAMINYL) 1 (N,N DIETHYLAMINO)DIAZEN 1 IUM 1,2 DIOLATE; AZO COMPOUND; GLYCOSIDE; GLYCOSYLATED DIAZENIUMDIOLATE DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; N ACETYLGLUCOSAMINE; NITRIC OXIDE; PRODRUG;

ALKALINITY; ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL CULTURE; CULTURE MEDIUM; DRUG EFFECT; DRUG HYDROLYSIS; DRUG STRUCTURE; LEISHMANIA MAJOR; LEISHMANIASIS; MACROPHAGE; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; REACTION TIME; STRUCTURE ANALYSIS; X RAY DIFFRACTION;

ANIMALS; ANTIPROTOZOAL AGENTS; AZO COMPOUNDS; CARBOHYDRATES; CRYSTALLOGRAPHY, X-RAY; GLYCOSYLATION; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; LEISHMANIA MAJOR; MACROPHAGES; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITRIC OXIDE; OXYGEN; PRODRUGS;

EID: 46849095164     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8000482     Document Type: Article

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