Neuron-like differentiation and selective ablation of undifferentiated embryonic stem cells containing suicide gene with Oct-4 promoter

Stem Cells and Development

Volumn 17, Issue 4, 2008, Pages 619-627

  Hara, Akira ^a   Aoki, Hitomi ^a   Taguchi, Ayako ^a   Niwa, Masayuki ^b   Yamada, Yasuhiro ^a   Kunisada, Takahiro ^a   Mori, Hideki ^a  

^a GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b GIFU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TUBULIN; GANCICLOVIR; GLIAL FIBRILLARY ACIDIC PROTEIN; KI 67 ANTIGEN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN KINASE C; SYNAPTOPHYSIN; SYNTAXIN; THYMIDINE KINASE; VESICULAR GLUTAMATE TRANSPORTER 1;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL SURVIVAL; EMBRYONIC STEM CELL; GENE EXPRESSION; HERPES SIMPLEX VIRUS; MOUSE; NERVE CELL; NERVE CELL NETWORK; NONHUMAN; PRIORITY JOURNAL; SUICIDE GENE; SYNAPSE; TERATOMA; TRANSGENE;

ANIMALS; ANTIGENS, DIFFERENTIATION; ANTIVIRAL AGENTS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; EMBRYONIC STEM CELLS; GANCICLOVIR; GENES, TRANSGENIC, SUICIDE; MICE; NEURONS; OCTAMER TRANSCRIPTION FACTOR-3; PROMOTER REGIONS (GENETICS); SIMPLEXVIRUS; THYMIDINE KINASE; VIRAL PROTEINS;

SIMPLEXVIRUS;

EID: 46749159104     PISSN: 15473287     EISSN: None     Source Type: Journal    
DOI: 10.1089/scd.2007.0235     Document Type: Article

References (34)

1. Resnick JL, LS Bixler, L Cheng and PJ Donovan. (1992). Long-term proliferation of mouse primordial germ cells in culture. Nature 359:550-551.
2. Thomson JA, J Itskovitz-Eldor, SS Shapiro, MA Waknitz, JJ Swiergiel, VS Marshall and JM Jones. (1998). Embryonic stem cell lines derived from human blastocysts. Science 282:1145-1147.
3. Bieberich E, J Silva, G Wang, K Krishnamurthy and BG Condie. (2004). Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants. J Cell Biol 167:723-734.
4. Bjorklund LM, R Sanchez-Pernaute, S Chung, T Andersson, IY Chen, KS McNaught, AL Brownell, BG Jenkins, C Wahlestedt, KS Kim and O Isacson. (2002). Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci USA 99:2344-2349.
5. Hara A, M Niwa, M Kumada, H Aoki, T Kunisada, T Oyama, T Yamamoto, O Kozawa and H Mori. (2006). Intraocular injection of folate antagonist methotrexate induces neuronal differentiation of embryonic stem cells transplanted in the adult mouse retina. Brain Res 1085:33-42.
6. Parish CL, S Parisi, MG Persico, E Arenas and G Minchiotti. (2005). Cripto as a target for improving embryonic stem cell-based therapy in Parkinson's disease. Stem Cells 23:471-476.
7. Goodwin NC, Y Ishida, S Hartford, C Wnek, RA Bergstrom, P Leder and JC Schimenti. (2001). DelBank: a mouse ES-cell resource for generating deletions. Nat Genet 28:310-311.
8. Schuldiner M, J Itskovitz-Eldor and N Benvenisty. (2003). Selective ablation of human embryonic stem cells expressing a "suicide" gene. Stem Cells 21:257-265.
9. Niwa H, J Miyazaki and AG Smith. (2000). Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24:372-376.
10. Pesce M and HR Scholer. (2001). Oct-4: gatekeeper in the beginnings of mammalian development. Stem Cells 19:271-278.
11. Ovitt CE and HR Scholer. (1998). The molecular biology of Oct-4 in the early mouse embryo. Mol Hum Reprod 4:1021-1031.
12. Hoei-Hansen CE, K Almstrup, JE Nielsen, S Brask Sonne, N Graem, NE Skakkebaek, H Leffers and E Rajpert-De Meyts. (2005). Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours. Histopathology 47:48-56.
13. Palumbo C, K van Roozendaal, AJ Gillis, RH van Gurp, H de Munnik, JW Oosterhuis, EJ van Zoelen and LH Looijenga. (2002). Expression of the PDGF alpha-receptor 1.5 kb transcript, OCT-4, and c-KIT in human normal and malignant tissues. Implications for the early diagnosis of testicular germ cell tumours and for our understanding of regulatory mechanisms. J Pathol 196:467-477.
14. Hara A, N Oka, H Aoki, A Taguchi, Y Yamada, M Niwa and H Mori. (2008). OCT-3/4 Expressing Cells as Cancer Stem Cells in Human Immature Teratoma: Cancer Differentiation Potential. Nova Science Publishers, Inc, New York.
15. Aoki H, A Hara, S Nakagawa, T Motohashi, M Hirano, Y Takahashi and T Kunisada. (2006). Embryonic stem cells that differentiate into RPE cell precursors in vitro develop into RPE cell monolayers in vivo. Exp Eye Res 82:265-274.
16. Hidaka K, JK Lee, HS Kim, CH Ihm, A Iio, M Ogawa, S Nishikawa, I Kodama and T Morisaki. (2003). Chamber-specific differentiation of Nkx2.5-positive cardiac precursor cells from murine embryonic stem cells. FASEB J 17:740-742.
17. Nakagawa S, S Takada, R Takada and M Takeichi. (2003). Identification of the laminar-inducing factor: Wnt-signal from the anterior rim induces correct laminar formation of the neural retina in vitro. Dev Biol 260:414-425.
18. Niwa H. (2007). How is pluripotency determined and maintained? Development 134:635-646.
19. Pesce M and HR Scholer. (2000). Oct-4: control of totipotency and germline determination. Mol Reprod Dev 55:452-457.
20. Maeda M, K Namikawa, I Kobayashi, N Ohba, Y Takahara, C Kadono, A Tanaka and H Kiyama. (2006). Targeted gene therapy toward astrocytoma using a Cre/loxP-based adenovirus system. Brain Res 1081:34-43.
21. Uckert W, T Kammertons, K Haack, Z Qin, J Gebert, DJ Schendel and T Blankenstein. (1998). Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo. Hum Gene Ther 9:855-865.
22. Sandmair AM, M Turunen, K Tyynela, S Loimas, P Vainio, R Vanninen, M Vapalahti, R Bjerkvig, J Janne and S Yla-Herttuala. (2000). Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions. Cancer Gene Ther 7:413-421.
23. Huang H and X Tang. (2003). Phenotypic determination and characterization of nestin-positive precursors derived from human fetal pancreas. Lab Invest 83:539-547.
24. Heit JJ and SK Kim. (2004). Embryonic stem cells and islet replacement in diabetes mellitus. Pediatr Diabetes 5 Suppl 2:5-15.
25. Moon SY, YB Park, DS Kim, SK Oh and DW Kim. (2006). Generation, culture, and differentiation of human embryonic stem cells for therapeutic applications. Mol Ther 13:5-14.
26. Keller G. (2005). Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev 19:1129-1155.
27. Fujikawa T, SH Oh, L Pi, HM Hatch, T Shupe and BE Petersen. (2005). Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells. Am J Pathol 166:1781-1791.
28. Arnhold S, H Klein, I Semkova, K Addicks and U Schraermeyer. (2004). Neurally selected embryonic stem cells induce tumor formation after long-term survival following engraftment into the subretinal space. Invest Ophthalmol Vis Sci 45:4251-4255.
29. Dihne M, C Bernreuther, C Hagel, KO Wesche and M Schachner. (2006). Embryonic stem cell-derived neuronally committed precursor cells with reduced teratoma formation after transplantation into the lesioned adult mouse brain. Stem Cells 24:1458-1466.
30. Nishimura F, M Yoshikawa, S Kanda, M Nonaka, H Yokota, A Shiroi, H Nakase, H Hirabayashi, Y Ouji, J Birumachi, S Ishizaka and T Sakaki. (2003). Potential use of embryonic stem cells for the treatment of mouse parkinsonian models: improved behavior by transplantation of in vitro differentiated dopaminergic neurons from embryonic stem cells. Stem Cells 21:171-180.
31. Iacovitti L, AE Donaldson, CE Marshall, S Suon and M Yang. (2007). A protocol for the differentiation of human embryonic stem cells into dopaminergic neurons using only chemically defined human additives: Studies in vitro and in vivo. Brain Res 1127:19-25.
32. Brederlau A, AS Correia, SV Anisimov, M Elmi, G Paul, L Roybon, A Morizane, F Bergquist, I Riebe, U Nannmark, M Carta, E Hanse, J Takahashi, Y Sasai, K Funa, P Brundin, PS Eriksson and JY Li. (2006). Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation. Stem Cells 24:1433-1440.
33. Mueller-Klieser W. (1997). Three-dimensional cell cultures: from molecular mechanisms to clinical applications. Am J Physiol 273:C1109-C1123.
34. Layer PG, A Robitzki, A Rothermel and E Willbold. (2002). Of layers and spheres: the reaggregate approach in tissue engineering. Trends Neurosci 25:131-134.