Identification of natural coumarin compounds that rescue defective ΔF508-CFTR chloride channel gating

Clinical and Experimental Pharmacology and Physiology

Volumn 35, Issue 8, 2008, Pages 878-883

  Xu, Li Na ^a   Na, Wan Li ^b   Liu, Xin ^b   Hou, Shu Guang ^c   Lin, Sen ^c   Yang, Hong ^c   Ma, Tong Hui ^a  

^a NORTHEAST NORMAL UNIVERSITY   (China)

^b JILIN UNIVERSITY   (China)

^c LIAONING NORMAL UNIVERSITY   (China)

Author keywords

F508 mutation; Activator; Coumarins; Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel; Pharmacological therapy

Indexed keywords

ANGELICIN; CHLORIDE CHANNEL; COUMARIN DERIVATIVE; FORSKOLIN; GENISTEIN; IODIDE; OSTHOLE; PENTOSALEN; PRAERUPTORIN A; PROTEIN INHIBITOR; SCOPOLETIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; TRANSMEMBRANE CONDUCTANCE REGULATOR INHIBITOR; YELLOW FLUORESCENT PROTEIN;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CHINESE HERB; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SCREENING; EPITHELIUM CELL; FISCHER 344 RAT; FLUORESCENCE ANALYSIS; NONHUMAN; PROTEIN EXPRESSION; RAT; THYROID GLAND;

ANIMALS; BACTERIAL PROTEINS; BIOLOGICAL PRODUCTS; CELL LINE; COUMARINS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ION CHANNEL GATING; KINETICS; LUMINESCENT PROTEINS; MOLECULAR STRUCTURE; RATS; RATS, INBRED F344; THYROID GLAND;

EID: 46749153053     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2008.04943.x     Document Type: Article

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