Fractionated marine invertebrate extract libraries for drug discovery

Molecules

Volumn 13, Issue 6, 2008, Pages 1372-1383

  Bugni, Tim S ^a   Harper, Mary Kay ^a   McCulloch, Malcolm W B ^a   Reppart, Jason ^a   Ireland, Chris M ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

HP20SS; LCMS; Marine natural products; Prefractionation; Sponge; Tunicate

Indexed keywords

BIOLOGICAL PRODUCT;

ANIMAL; ARTICLE; CHEMISTRY; DRUG SCREENING; FRACTIONATION; INVERTEBRATE; ISOLATION AND PURIFICATION; METHODOLOGY; MOLECULAR LIBRARY;

ANIMALS; BIOLOGICAL PRODUCTS; CHEMICAL FRACTIONATION; DRUG EVALUATION, PRECLINICAL; INVERTEBRATES; SMALL MOLECULE LIBRARIES;

EID: 46749120720     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules13061372     Document Type: Article

References (28)

1. Blunt, J.W.; Copp, B.R.; Hu, W.P.; Munro, M.H.; Northcote, P.T.; Prinsep, M.R. Marine Natural Products. Nat. Prod. Rep. 2008, 25, 35-94.
2. Newman, D.J.; Cragg, G.M. Natural Products from Marine Invertebrates and Microbes as Modulators of Antitumor Targets. Curr. Drug Targets 2006, 7, 279-304.
3. Newman, D.J.; Cragg, G.M. Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials. J. Nat. Prod. 2004, 67, 1216-1238.
4. Rinehart, K.L.; Holt, T.G.; Fregeau, N.L.; Stroh, J.G.; Keifer, P.A.; Sun, F.; Li, L.H.; Martin, D.G. Ecteinascidins 729, 743, 745, 759a, 759b, and 770: Potent Antitumor Agents from the Caribbean Tunicate Ecteinascidia turbinata. J. Org. Chem. 1990, 55, 4512-4515.
5. Wright, A.E.; Forleo, D.A.; Gunawardana, G.P.; Gunasekera, S.P.; Koehn, F.E.; McConnell, O.J. Antitumor Tetrahydroisoquinoline Alkaloids from the Colonial Ascidian Ecteinascidia turbinata. J. Org. Chem. 1990, 55, 4508-4512.
6. Sakai, R.; Rinehart, K.L.; Kishore, V.; Kundu, B.; Faircloth, G.; Gloer, J.B.; Carney, J.R.; Namikoshi, M.; Sun, F.; Hughes, R.G.; Gravalos, D.G.; de Quesada, T.G.; Wilson, G.R.; Heid, R.M. Structure-Activity Relationships of the Didemnins. J. Med. Chem. 1996, 39, 2819-2834.
7. Urdiales, J.L.; Morata, P.; Nunez De Castro, I.; Sanchez-Jimenez, F. Antiproliferative Effect of Dehydrodidemnin B (Ddb), a Depsipeptide Isolated from Mediterranean Tunicates. Cancer Lett. 1996, 102, 31-37.
8. Butler, M.S. Natural Products to Drugs: Natural Product-Derived Compounds in Clinical Trials. Nat. Prod. Rep. 2008, 25, 475-516.
9. Ireland, C.M.; Aalbersberg, W.; Andersen, R.J.; Ayral-Kaloustian, S.; Berlinck, R.G.S.; Bernan, V.S.; Carter, G.T.; Churchill, A.C.L.; Clardy, J.; Concepcion, G.P.; De Silva, E.D.; Discafani, C.; Fojo, T.; Frost, P.; Gibson, D.; Greenberger, L.M.; Greenstein, M.; Harper, M.K.; Mallon, R.; Loganzo, F.; Nunes, M.; Poruchynsky, M.S.; Zask, A. Anticancer Agents from Unique Natural Products Sources. Pharmaceutical Biology 2003, 41, 15-38.
10. Appleton, D.R.; Buss, A.D.; Butler, M.S. A Simple Method for High-Throughput Extract Prefractionation for Biological Screening. Chimia 2007, 61, 327-331.
11. Harvey, A.L. Natural Products as a Screening Resource. Curr. Opin. Chem. Biol. 2007, 11, 480-484.
12. Koehn, F.E. High Impact Technologies for Natural Products Screening. Prog. Drug Res. 2008, 65, 177-210.
13. Koehn, F.E.; Carter, G.T. The Evolving Role of Natural Products in Drug Discovery. Nat. Rev. Drug Discov. 2005, 4, 206-220.
14. Lam, K.S. New Aspects of Natural Products in Drug Discovery. Trends Microbiol. 2007, 15, 279-289.
15. Feng, B.Y.; Shoichet, B.K. Synergy and Antagonism of Promiscuous Inhibition in Multiple-Compound Mixtures. J. Med. Chem. 2006, 49, 2151-2154.
16. Schmid, I.; Sattler, I.; Grabley, S.; Thiericke, R. Natural Products in High Throughput Screening: Automated High-Quality Sample Preparation. J. Biomol. Screen. 1999, 4, 15-25.
17. Bugni, T.S.; Richards, B.; Bhoite, L.; Cimbora, D.; Harper, M.K.; Ireland, C.M. Marine Natural Product Libraries for High-Throughput Screening and Rapid Drug Discovery. J. Nat. Prod. 2008, 71, [Epub ahead of print].
18. Potterat, O.; Hamburger, M. Natural Products in Drug Discovery - Concepts and Approaches for Tracking Bioactivity. Curr. Org. Chem. 2006, 10, 899-920.
19. Svec, F.; Huber, C.G. Monolithic Materials: Promises, Challenges, Achievements. Anal. Chem. 2006, 78, 2101-2107.
20. McCulloch, M.W.B.; Coombs, G.S.; Banerjee, N.; Bugni, T.S.; Cannon, K.M.; Harper, M.K.; Veltri, C.A.; Virshup, D.M.; Ireland, C.M. Psammaplin A as a General Activator of Cell Based Signaling Assays via HDAC Inhibition and Studies on Some Bromotyrosine Derivatives. Bioorg. Med. Chem. 2008, 18, submitted manuscript.
21. Davies-Coleman, M.T.; Faulkner, D.J.; Dubowchik, G.M.; Roth, G.P.; Polson, C.; Fairchild, C. A New EGF-Active Polymeric Pyridinium Alkaloid from the Sponge Callyspongia fibrosa. J. Org. Chem. 1993, 58, 5925-5930.
22. Cremin, P.A.; Zeng, L. High-Throughput Analysis of Natural Product Compound Libraries by Parallel LC-MS Evaporative Light Scattering Detection. Anal. Chem. 2002, 74, 5492-5500.
23. Eldridge, G.R.; Vervoort, H.C.; Lee, C.M.; Cremin, P.A.; Williams, C.T.; Hart, S.M.; Goering, M.G.; O'Neil-Johnson, M.; Zeng, L. High-Throughput Method for the Production and Analysis of Large Natural Product Libraries for Drug Discovery. Anal. Chem. 2002, 74, 3963-3971.
24. Newman, D.J.; Cragg, G.M. Natural Products as Sources of New Drugs over the Last 25 Years. J. Nat. Prod. 2007, 70, 461-477.
25. Newman, D.J. Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery? J. Med. Chem. 2008, 51, 2589-2599.
26. Fang, L.; Wan, M.; Pennacchio, M.; Pan, J. Evaluation of Evaporative Light-Scattering Detector for Combinatorial Library Quantitation by Reversed Phase HPLC. J. Comb. Chem. 2000, 2, 254-257.
27. Vervoort, N.; Daemen, D.; Török, G. Performance Evaluation of Evaporative Light Scattering Detection and Charged Aerosol Detection in Reversed Phase Liquid Chromatography. J. Chromatogr. A 2008, 1189, 92-100.
28. 1H-NMR Spectroscopy. J. Nat. Prod. 2008, 71, 810-813.