Vitamin C pharmacokinetics after continuous infusion in a patient with prostate cancer [1]

Annals of Pharmacotherapy

Volumn 41, Issue 6, 2007, Pages 1082-1083

  Duconge, Jorge ^a   Miranda Massari, Jorge R ^a   Gonzalez, Michael J ^a   Taylor, Paul R ^b   Riordan, Hugh D ^b   Riordan, Neil H ^b   Casciari, Joseph J ^c   Alliston, Kevin ^b  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^b The Center for the Improvement of Human Functioning International   (United States)

^c Bio Communications Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; MEGA C ACID PLUS; UNCLASSIFIED DRUG;

AGED; AREA UNDER THE CURVE; CASE REPORT; CONTINUOUS INFUSION; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG EXCRETION; DRUG HALF LIFE; DRUG MEGADOSE; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY CLEARANCE; KIDNEY TUBULE ABSORPTION; LETTER; MALE; MULTIPLE CYCLE TREATMENT; PRIORITY JOURNAL; PROSTATE CANCER; BLOOD; DRUG ADMINISTRATION; HALF LIFE TIME; METABOLISM; PROSTATE TUMOR;

AGED; AREA UNDER CURVE; ASCORBIC ACID; DRUG ADMINISTRATION SCHEDULE; HALF-LIFE; HUMANS; MALE; PROSTATIC NEOPLASMS;

EID: 34250155252     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1H654     Document Type: Letter

References (5)

1. Riordan NH, Riordan HD, Meng XL, Li Y, Jackson JA. Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent. Med Hypotheses 1995;44:207-13.
2. Casciari JJ, Riordan HD, Miranda-Massari JR, Gonzalez MJ. Effects of high dose ascorbate administration on L-10 tumour growth in guinea pigs. P R Health Sci J 2005;24:145-50.
3. Levine M, Conry-Cantilena C, Wang Y, et al. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A 1996;93:3704-9.
4. Hickey DS, Roberts HJ, Cathcart RF. Dynamic flow: a new model for ascorbate. J Orthomolecular Med 2005;20:237-44.
5. Blanchard J, Tozer TN, Rowland M. Pharmacokinetic perspectives on megadoses of ascorbic acid. Am J Clin Nutr 1997;66:1165-71.