Directions in QSAR modeling for regulatory uses in OECD member countries, EU and in Russia

Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews

Volumn 26, Issue 2, 2008, Pages 201-236

  Fjodorova, Natalja ^a   Novich, Marjana ^a   Vrachko, Marjan ^a   Smirnov, Vjacheslav ^b   Kharchevnikova, Nina ^c   Zholdakova, Zoya ^c   Novikov, Sergei ^c   Skvortsova, Natalja ^c   Filimonov, Dmitrii ^d   Poroikov, Vladimir ^d   Benfenati, Emilio ^e  

^a NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^b N N BLOKHIN NATIONAL MEDICAL RESEARCH CENTER OF ONCOLOGY   (Russian Federation)

^c INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

^d INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

^e MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Biokinetic modeling; Computational toxicology; Evaluation and authorization of chemicals (REACH); Expert systems; Human health effects; Metabolism; Prediction; Quantitative structure activity relationships (QSARs); Registration; Regulatory agencies

Indexed keywords

MOLECULAR GRAPHICS;

EUROPEAN UNION (EU); MEMBER COUNTRIES; QSAR MODELING; QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP (QSAR) MODELING;

SULFUR COMPOUNDS;

BROMOBENZENE; CHEMICAL COMPOUND; CHLOROBENZENE; HYDROGEN; TOXIC SUBSTANCE; WATER;

ACUTE TOXICITY; ALGORITHM; AMES TEST; BIODEGRADATION; BIOLOGICAL ACTIVITY; BIOTRANSFORMATION; CARCINOGENICITY; COMPUTER MODEL; COMPUTER PROGRAM; DANGEROUS GOODS; DIPOLE; ECONOMICS; ECOTOXICITY; ELECTRONICS; ENVIRONMENTAL IMPACT; EPIDEMIOLOGICAL DATA; EUROPEAN UNION; EXPERIMENTAL DESIGN; EXPERT SYSTEM; GENOTOXICITY; HEALTH HAZARD; HYDROGEN BOND; IN VITRO STUDY; INFRARED SPECTROSCOPY; INTERNET; INTOXICATION; LD 50; MELTING POINT; MICRONUCLEUS TEST; MODEL; MOLECULAR WEIGHT; ORGANIZATION; PATHOGENICITY; PHYSICAL CHEMISTRY; PRACTICE GUIDELINE; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; RISK ASSESSMENT; RUSSIAN FEDERATION; STATISTICAL ANALYSIS; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; VALIDATION STUDY; XENOBIOTIC METABOLISM; ANIMAL; ANIMAL EXPERIMENT; ANIMAL TESTING ALTERNATIVE; BIOLOGICAL MODEL; CLASSIFICATION; EUROPE; HUMAN; PACKAGING; POLICY; PREDICTION AND FORECASTING; TOXICITY TESTING;

ANIMAL EXPERIMENTATION; ANIMAL USE ALTERNATIVES; ANIMALS; EUROPE; HAZARDOUS SUBSTANCES; HUMANS; MODELS, BIOLOGICAL; PREDICTIVE VALUE OF TESTS; PRODUCT LABELING; PUBLIC POLICY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RISK ASSESSMENT; RUSSIA; TOXICITY TESTS;

EID: 46749087028     PISSN: 10590501     EISSN: 15324095     Source Type: Journal    
DOI: 10.1080/10590500802135578     Document Type: Review

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