Recent advances in gene delivery with ultrasound and microbubbles

Journal of Experimental Nanoscience

Volumn 3, Issue 1, 2008, Pages 17-40

  Pichon, Chantal ^a   Kaddur, Kadija ^b,c   Midoux, Patrick ^a   Tranquart, Francois ^b,c   Bouakaz, Ayache ^b,c  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE TOURS   (France)

Author keywords

Contrast agent; Gene transfer electroporation; Sonoporation

Indexed keywords

ACOUSTIC WAVES; CELL MEMBRANES; GENE TRANSFER; HEALTH; MECHANISMS; NUCLEIC ACIDS; ORGANIC ACIDS; STABILIZERS (AGENTS); ULTRASONIC TRANSMISSION; ULTRASONICS;

ACOUSTIC MICROSTREAMING; BUBBLE CHARACTERISTICS; DIAGNOSTIC APPLICATIONS; ELECTROPORATION; GENE DELIVERY; IN VIVO GENE DELIVERY; IN-VITRO; IN-VIVO; MICRO BUBBLES; MICRO-BUBBLES; SONOPORATION; ULTRASOUND CONTRAST AGENTS (USCAS); ULTRASOUND PARAMETERS;

ULTRASONIC IMAGING;

'BIOSPHERE'; ALBUNEX; BETA INTERFERON; BLOOD CLOTTING FACTOR 9; CONTRAST MEDIUM; DNA; FLUORESCEIN ISOTHIOCYANATE; GREEN FLUORESCENT PROTEIN; HEXOKINASE; HUMAN INSULIN; LUCIFERASE; NANOSPHERE; OLIGONUCLEOTIDE; PERFLUBUTANE; PERFLUTREN; PLASMID DNA; PROTEIN P53; SCATTER FACTOR; SHU 508; SMAD7 PROTEIN; SMALL INTERFERING RNA; SONOVUE; TISSUE INHIBITOR OF METALLOPROTEINASE 3; VASCULOTROPIN;

ACUTE HEART INFARCTION; ANGIOPLASTY; ARTICLE; CELL MEMBRANE PERMEABILITY; ELECTROPORATION; FOOD AND DRUG ADMINISTRATION; GENE DELIVERY SYSTEM; GENE TRANSFER; HEMOPHILIA B; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY FIBROSIS; LIVER CELL CARCINOMA; MICROBUBBLE; NONHUMAN; PRIORITY JOURNAL; RESTENOSIS; SAFETY; SHEAR STRESS; ULTRASOUND;

EID: 46649116283     PISSN: 17458080     EISSN: 17458099     Source Type: Journal    
DOI: 10.1080/17458080801993422     Document Type: Article

References (80)

1. Raper, SE (2003) Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol. Genet. Metab., 80, pp. 148-158.
2. Hacein-Bey-Abina, S. (2003) A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N. Engl. J. Med., 348, pp. 255-256.
3. Hacein-Bey-Abina, S. (2003) LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science, 302, pp. 415-419.
4. Rolland, AP (1998) From genes to gene medicines: Recent advances in nonviral gene delivery. Crit. Rev. Ther. Drug. Carrier Syst., 15, pp. 143-198.
5. Mahato, RI (1999) Non-viral peptide-based approaches to gene delivery. J. Drug Target., 7, pp. 249-268.
6. Bouakaz, A. and de Jong, N. (2007) WFUMB safety symposium on echo-contrast agents: Nature and types of ultrasound contrast agents. Ultrasound Med. Biol., 33, pp. 187-196.
7. Schneider, M. (1995) BR1: A new ultrasonographic contrast agent based on sulfur hexafluoride-filled microbubbles. Invest. Radiol., 30, pp. 451-457.
8. Bouakaz, A., Versluis, M. and de Jong, N. (2005) High-speed optical observations of contrast agent destruction. Ultrasound Med. Biol., 31, pp. 391-399.
9. Simpson, D., Chin, C. and Burns, P. (1999) Pulse inversion Doppler: A new method for detecting nonlinear echoes from microbubble contrast agents. IEEE Trans. Ultrason. Ferr. Freq. Con., 46, pp. 372-382.
10. Unger, EC (2004) Therapeutic applications of lipid-coated microbubbles. Adv. Drug. Deliv. Rev., 56, pp. 1291-1314.
11. Haag, P. (2006) Microbubble-enhanced ultrasound to deliver an antisense oligodeoxynucleotide targeting the human androgen receptor into prostate tumours. J. Steroid. Biochem. Mol. Biol., 102, pp. 103-113.
12. Van Wamel, A. (2004) Radionuclide tumour therapy with ultrasound contrast microbubbles. Ultrasonics, 42, pp. 903-906.
13. Duvshani-Eshet, M. and Machluf, M. (2007) Efficient transfection of tumors facilitated by long-term therapeutic ultrasound in combination with contrast agent: From in vitro to in vivo setting. Cancer Gene Ther., 14, pp. 306-315.
14. Taniyama, Y. (2002) Local delivery of plasmid DNA into rat carotid artery using ultrasound. Circulation, 105, pp. 1233-1239.
15. Mehier-Humbert, S. (2005) Ultrasound-mediated gene delivery: Kinetics of plasmid internalisation and gene expression. J. Control Release, 104, pp. 203-211.
16. Mehier-Humbert, S. (2005) Plasma membrane poration induced by ultrasound exposure: Implication for drug delivery. J. Control Release, 104, pp. 213-222.
17. Greenleaf, WJ (1998) Artificial cavitation nuclei significantly enhance acoustically induced cell transfection. Ultrasound Med. Biol., 24, pp. 587-595.
18. Lawrie, A. (2000) Microbubble-enhanced ultrasound for vascular gene delivery. Gene Therapy, 7, pp. 2023-2027.
19. Duvshani-Eshet, M. and Machluf, M. (2005) Therapeutic ultrasound optimization for gene delivery: A key factor achieving nuclear DNA localisation. J. Control Release, 108, pp. 513-528.
20. Miller, DL, Dou, C. and Song, J. (2003) DNA transfer and cell killing in epidermoid cells by diagnostic ultrasound activation of contrast agent gas bodies in vitro. Ultrasound Med. Biol., 29, pp. 601-607.
21. Nie, F. (2006) Microbubble-enhanced ultrasound exposure improves gene transfer in vascular endothelial cells. World. J. Gastroenterol, 12, pp. 7508-7513.
22. Li, T., Tachibana, K. and Kuroki, M. (2003) Gene transfer with echo-enhanced contrast agents: Comparison between Albunex, Optison, and Levovist in mice-initial results. Radiology, 229, pp. 423-428.
23. Kaddur, K. (2007) International Congress on Ultrasonics. Optimizing ultrasound parameters for an efficient gene transfer in human glioblastoma cell line with BR14 gas microbubbles
24. Mehier-Humbert, S. (2007) Ultrasound-mediated gene delivery: Influence of contrast agent on transfection. Bioconjug. Chem., 18, pp. 652-662.
25. Bekeredjian, R. (2003) Ultrasound targeted microbubble destruction can repeatedly direct highly specific plasmid expression to the heart. Circulation, 108, pp. 1022-1026.
26. Tsunoda, S. (2005) Sonoporation using microbubble BR14 promotes pDNA/ siRNA transduction to murine heart. Biochem. Biophys. Res. Commun., 336, pp. 118-127.
27. Kodama, T. (2005) Delivery of oligodeoxynucleotides into human saphenous veins and the adjunct effect of ultrasound and microbubbles. Ultrasound Med. Biol., 31, pp. 1683-1691.
28. Vancraeynest, D. (2006) Myocardial delivery of colloid nanoparticles using ultrasound-targeted microbubble destruction. Eur. Heart J., 27, pp. 237-245.
29. Wang, X. (2005) Gene transfer with microbubble ultrasound and plasmid DNA into skeletal muscle of mice: Comparison between commercially available microbubble contrast agents. Radiology, 237, pp. 224-229.
30. Shimamura, M. (2004) Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound. Gene Ther., 11, pp. 1532-1539.
31. Sakakima, Y. (2005) Gene therapy for hepatocellular carcinoma using sonoporation enhanced by contrast agents. Cancer Gene Ther., 12, pp. 884-889.
32. Kondo, I. (2004) Treatment of acute myocardial infarction by hepatocyte growth factor gene transfer: The first demonstration of myocardial transfer of a 'functional' gene using ultrasonic microbubble destruction. J. Am. Coll. Cardiol., 44, pp. 644-653.
33. Chen, S. (2006) Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology. Proc. Natl. Acad. Sci. USA, 103, pp. 8469-8474.
34. Korpanty, G. (2005) Targeting of VEGF-mediated angiogenesis to rat myocardium using ultrasonic destruction of microbubbles. Gene Ther., 12, pp. 1305-1312.
35. Miao, CH (2005) Ultrasound enhances gene delivery of human factor IX plasmid. Hum. Gene Ther., 16, pp. 893-905.
36. Lan, HY (2003) Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. J. Am. Soc. Nephrol., 14, pp. 1535-1548.
37. Akowuah, EF (2005) Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model. Gene Ther., 12, pp. 1154-1157.
38. Sheikov, N. (2004) Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles. Ultrasound Med. Biol., 30, pp. 979-989.
39. Hynynen, K. (2003) Non-invasive opening of BBB by focused ultrasound. Acta Neurochir. Suppl., 86, pp. 555-558.
40. Song, J. (2002) Influence of injection site, microvascular pressure and ultrasound variables on microbubble-mediated delivery of microspheres to muscle. J. Am. Coll. Cardiol., 39, pp. 726-731.
41. Miller, DL, Pislaru, SV and Greenleaf, JE (2002) Sonoporation: mechanical DNA delivery by ultrasonic cavitation. Somat. Cell Mol. Genet., 27, pp. 115-134.
42. Christiansen, JP (2003) Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubbles. Ultrasound Med. Biol., 29, pp. 1759-1767.
43. Hauff, P. (2005) Evaluation of gas-filled microparticles and sonoporation as gene delivery system: Feasibility study in rodent tumor models. Radiology, 236, pp. 572-578.
44. Iwanaga, K. (2007) Local delivery system of cytotoxic agents to tumors by focused sonoporation. Cancer Gene Ther., 14, pp. 354-363.
45. Marmottant, P. and Hilgenfeldt, S. (2003) Controlled vesicle deformation and lysis by single oscillating bubbles. Nature, 423, pp. 153-156.
46. Deng, CX (2004) Ultrasound-induced cell membrane porosity. Ultrasound Med. Biol., 30, pp. 519-526.
47. Van Wamel, A. (2004) Micromanipulation of endothelial cells: ultrasound-microbubble-cell interaction. Ultrasound Med. Biol., 30, pp. 1255-1258.
48. Postema, M. (2005) High-speed photography during ultrasound illustrates potential therapeutic applications of microbubbles. Med. Phys., 32, pp. 3707-3711.
49. Tran, TA (2007) Effect of ultrasound-activated microbubbles on the cell electrophysiological properties. Ultrasound Med. Biol., 33, pp. 158-163.
50. Duvshani-Eshet, M. (2006) Therapeutic ultrasound-mediated DNA to cell and nucleus: Bioeffects revealed by confocal and atomic force microscopy. Gene Ther., 13, pp. 163-172.
51. Xie, TD and Tsong, TY (1993) Study of mechanisms of electric field-induced DNA transfection. Effects of DNA topology on surface binding, cell uptake, expression, and integration into host chromosomes of DNA in the mammalian cell. Biophys. J., 65, pp. 1684-1689.
52. Teissie, J. and Rols, MP (1994) Manipulation of cell cytoskeleton affects the lifetime of cell membrane electropermeabilisation. Ann. N Y Acad. Sci., 720, pp. 98-110.
53. de Gennes, PG (1999) Passive entry of a DNA molecule into a small pore. Proc. Natl. Acad. Sci. USA, 96, pp. 7262-7264.
54. Neumann, E. (1982) Gene transfer into mouse lyoma cells by electroporation in high electric fields. Embo. J., 1, pp. 841-845.
55. Teissie, J. (1999) Electropermeabilisation of cell membranes. Adv. Drug. Deliv. Rev., 35, pp. 3-19.
56. Chang, DC (1979) A physical model of nerve axon. II: Action potential and excitation currents. Voltage-clamp studies of chemical driving forces of Na+ and K+ in squid giant axon. Physiol. Chem. Phys., 11, pp. 263-288.
57. Glaser, RW (1988) Reversible electrical breakdown of lipid bilayers: formation and evolution of pores. Biochim. Biophys. Acta, 940, pp. 275-287.
58. Gowrishankar, TR, Chen, W. and Lee, RC (1998) Non-linear microscale alterations in membrane transport by electropermeabilisation. Ann. N Y Acad. Sci., 858, pp. 205-216.
59. Bier, M. (1999) Kinetics of sealing for transient electropores in isolated mammalian skeletal muscle cells. Bioelectromagnetics, 20, pp. 194-201.
60. Gabriel, B. and Teissie, J. (1997) Direct observation in the millisecond time range of fluorescent molecule asymmetrical interaction with the electropermeabilised cell membrane. Biophys. J., 73, pp. 2630-2637.
61. Teissie, J. and Tsong, TY (1980) Evidence of voltage-induced channel opening in Na/K ATPase of human erythrocyte membrane. J Membr. Biol., 55, pp. 133-140.
62. Faurie, C. (2003) Cell and animal imaging of electrically mediated gene transfer. DNA Cell Biol., 22, pp. 777-783.
63. Faurie, C. (2004) Effect of electric field vectoriality on electrically mediated gene delivery in mammalian cells. Biochim. Biophys. Acta, 1665, pp. 92-100.
64. Bureau, MF (2004) Intramuscular plasmid DNA electrotransfer: biodistribution and degradation. Biochim. Biophys. Acta, 1676, pp. 138-148.
65. Andre, F. and Mir, LM (2004) DNA electrotransfer: Its principles and an updated review of its therapeutic applications. Gene Ther., 11, p. S33.
66. Wells, DJ (2004) Gene therapy progress and prospects: Electroporation and other physical methods. Gene Ther., 11, pp. 1363-1369.
67. Titomirov, AV, Sukharev, S. and Kistanova, E. (1991) In vivo electroporation and stable transformation of skin cells of newborn mice by plasmid DNA. Biochim. Biophys. Acta, 1088, pp. 131-134.
68. Nishi, T. (1996) High-efficiency in vivo gene transfer using intraarterial plasmid DNA injection following in vivo electroporation. Cancer Res., 56, pp. 1050-1055.
69. Miklavcic, D. (1998) The importance of electric field distribution for effective in vivo electroporation of tissues. Biophys. J., 74, pp. 2152-2158.
70. Zhang, L. (2002) Enhanced delivery of naked DNA to the skin by non-invasive in vivo electroporation. Biochim. Biophys. Acta, 1572, pp. 1-9.
71. Zhang, L. and Rabussay, DP (2002) Clinical evaluation of safety and human tolerance of electrical sensation induced by electric fields with non-invasive electrodes. Bioelectrochemistry, 56, pp. 233-236.
72. Liu, F. and Huang, L. (2002) A syringe electrode device for simultaneous injection of DNA and electrotransfer. Mol. Ther., 5, pp. 323-328.
73. Dona, M. (2003) Functional in vivo gene transfer into the myofibers of adult skeletal muscle. Biochem. Biophys. Res. Commun., 312, pp. 1132-1138.
74. Babiuk, S. (2003) Needle-free topical electroporation improves gene expression from plasmids administered in porcine skin. Mol. Ther., 8, pp. 992-998.
75. Siu, T., Rohling, R. and Chiao, M. (2007) Microdevice-based delivery of gene products using sonoporation. Biomed. Microdevices., 9, pp. 295-300.
76. Pasqualini, R., Arap, W. and McDonald, D. (2002) Probing the structural and molecular diversity of tumor vasculature. Trends Mol. Med., 8, pp. 563-571.
77. Hobbs, SK (1998) Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment. Proc. Natl. Acad. Sci. USA, 95, pp. 4607-4612.
78. Lanza, GM and Wickline, SA (2003) Targeted ultrasonic contrast agents for molecular imaging and therapy. Curr. Probl. Cardiol., 28, pp. 625-653.
79. Dayton, PA (2006) Application of ultrasound to selectively localize nanodroplets for targeted imaging and therapy. Mol. Imaging., 5, pp. 160-174.
80. Rapoport, N., Gao, Z. and Kennedy, A. (2007) Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy. J. Natl. Cancer Inst., 99, pp. 1095-1106.