The physiology of vitamin D: Current concepts

Indian Journal of Medical Research

Volumn 127, Issue 3, 2008, Pages 256-262

  Kochupillai, N ^a  

^a M S RAMAIAH MEDICAL COLLEGE   (India)

Author keywords

Bone mineral metabolism; Calcium; Vitamin D; Vitamin D receptor

Indexed keywords

CALCIDIOL 1 MONOOXYGENASE; CALCITRIOL; HORMONE PRECURSOR; VITAMIN D; VITAMIN D RECEPTOR;

ANTINEOPLASTIC ACTIVITY; BONE METABOLISM; BONE MINERAL; CALCIUM HOMEOSTASIS; CELL DIFFERENTIATION; CELL PROLIFERATION; ENDOCRINE SYSTEM; FUNCTIONAL GENOMICS; GENE TARGETING; GLOMERULOSCLEROSIS; HUMAN; HYDROXYLATION; IMMUNOMODULATION; KIDNEY FAILURE; KIDNEY PROXIMAL TUBULE; LIVER FUNCTION; MITOSIS INHIBITION; MOLECULAR EVOLUTION; NONHUMAN; PARATHYROID FUNCTION; PROTEIN PROCESSING; REVIEW; SECONDARY HYPERPARATHYROIDISM; VITAMIN D DEFICIENCY; VITAMIN METABOLISM;

BONE AND BONES; BONE DENSITY; CALCIUM; ENDOCRINE SYSTEM; HUMANS; RECEPTORS, CALCITRIOL; VITAMIN D;

EID: 46649088562     PISSN: 09715916     EISSN: 09715916     Source Type: Journal    
DOI: None     Document Type: Review

References (31)

1. Tang BMP, Eslick GD, Nowson C, Smith C, Bensoussan A. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 year and older: a meta-analysis. Lancet 2007; 370: 657-66.
2. Bland R, Hughes SV, Stewart PM, Hewison M. Direct regulation of 25-hydroxyvitamin D3 1_-hydroxylase by calcium in a human proximal tubule cell line (Abstract). Bone 1998; 23: S260.
3. Rost CR, Bikle DD, Kaplan RA. In vitro stimulation of 25-hydroxycholecalciferol 1 _-hydroxylation by parathyroid hormone in chick kidney slices: evidence for a role for adenosine 3_,5_-monophosphate. Endocrinology 1981; 108: 1002-6.
4. Schiavi SC, Kumar R. The phosphatonin pathway: new insights in phosphate homeostasis. Kidney Int 2004; 65: 1-14.
5. Rowe PSN, Kumagai Y, Garrett R, Blacher R, Escobada A, Mundy GR. CHO-cells expressing MEPE, PHEX and co-expressing MEPE/PHEX cause major changes in BMD, Pi and serum alkaline phosphatase in nude mice (Abstract). J Bone Miner Res 2002; 17: S211.
6. Sylvia VL, Schwartz Z, Ellis EB, Helm SH, Gomez R, Dean DD, et al. Nongenomic regulation of protein kinase C isoforms by the vitamin D metabolites 1 _,25-(OH)2D3 and 24R,25-(OH)2D3. J Cell Physiol 1996; 167: 380-93.
7. Henry HL, Norman AW. Vitamin D: metabolism and biological actions. Annu Rev Nutr 1984; 4: 493-520.
8. Tanaka Y, Deluca HF. The control of 25-hydroxyvitamin D metabolism by inorganic phosphorus. Arch Biochem Biophys 1973; 154: 566-74.
9. Cooke NE, Haddad JG. Vitamin D binding protein (Gc-globulin). Endocr Rev 1989; 10: 294-307.
10. Boyan BD, Dean DD, Sylvia VL, Schwartz Z. Nongenomic regulation of extracellular matrix events by vitamin D metabolites. J Cell Biochem 1994; 56: 331-9.
11. Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature 2003; 423: 337-42.
12. Brown AJ, Dusso A, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol 1999; 277: 157-75.
13. Koshiyama H, Sone T, Nakao K. Vitamin-D-receptor-gene polymorphism and bone loss. Lancet 1995; 345: 990-1.
14. Eisman JA. Genetics of osteoporosis. Endocr Rev 1999; 20: 788-804.
15. Carling T, Kindmark A, Hellman P, Lundgren E, Ljunghall S, Rastad J, et al. Vitamin D receptor genotypes in primary hyperparathyroidism. Nat Med 1995; 1: 1309-11.
16. Kontula K, Valimaki S, Kainulainen K, Viitanen AM, Keski-Oja J. Vitamin D receptor polymorphism and treatment of psoriasis with calcipotriol. Br J Dermatol 1997; 136: 977-8.
17. Uitterlinden AG, Fang Y, van Meurs JB, van Leenwen H, Pols HA. Vitamin D receptor gene polymorphisms in relation to vitamin D-related disease states. J Steroid Biochem Mol Biol 2004; 89: 187-93.
18. Khosla S. Minireview: the OPG/RANKL/RANK system. Endocrinology 2001; 142: 5050-5.
19. Dusso AS, Thadhani R, Slatopolsky E. Vitamin D receptor and analogs. Semin Nephrol 2004; 24: 10-6.
20. Denda M, Finch J, Brown AJ, Nishii Y, Kubodera N, Slatopolsky E. 1,25-Dihydroxyvitamin D3 and 22-oxacalcitriol prevent the decrease in vitamin D receptor content in the parathyroid glands of uremic rats. Kidney Int 1996; 50: 34-9.
21. Abe E, Miyaura C, Sakagami H, Takeda M, Konno K, Yamazaki T, et al. Differentiation of mouse myeloid leukemia cells induced by 1_,25-dihydroxyvitamin D3. Proc Natl Acad Sci USA 1981; 78: 4990-4.
22. Zittermann A. Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr 2003; 89: 552-72.
23. Adriana S. Dusso, Alex J. Brown, Eduardo Slatopolsky. Am J Physiol Renal Physiol 2005; 289: 8-28.
24. Schwartz GG, Whitlatch LW, Chen TC, Lokeshwar BL, Holick MF. Human prostate cells synthesize 1,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3. Cancer Epidemiol Biomarkers Prev 1998; 7: 391-5.
25. Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr 2004; 79: 362-71.
26. Hodgkin P, Kay GH, Hine PM, Lumb GA, Stanbury SW. Vitamin D deficiency in Asians at home and in Britain. Lancet 1973; 2: 167-72.
27. Harinarayan CV, Gupta N, Kochupillai N. Vitamin D status in primary hyperparathyroidism. Clin Endocrinol (oxf) 1995; 43: 351-8.
28. Goswami R, Gupta N, Goswami D, Marwaha RK, Tandon N, Kochupillai N. Prevalence and significance of low 25-hydroxyvitamin D concentrations in healthy subjects in Delhi. Am J Clin Nutr 2000; 72: 472-5.
29. Harinarayan CV, Ramalakshmi T, Prasad UV, Sudhakar D, Srinivasarao PVLN, Sarma KVS, et al. High prevalence of low dietary calcium, high phytate consumption and vitamin D deficiency in healthy south Indians. Am J Clin Nutr 2007; 85: 1062-7.
30. Susheela AK. Fluorosis: A doctor's handbook. New Delhi: Fluorosis Research & Rural Development Foundation sponsored by Ministry of Health & Family Welfare (Govt. of India) & WHO (SEARO), 2005.
31. Harinaryan CV, Kochupillai N, Madhu SV, Gupta N, Meunier PJ. Fluorotoxic metabolic bone disease: An osteorenal syndrome caused by excess fluoride ingestion in the tropics. Bone 2006; 39: 907-14.