Selective nosylation of 1-phenylpropane-1,3-diol and perchloric acid mediated Friedel-Crafts alkylation: Key steps for the new and straightforward synthesis of tolterodine

Synthesis

Volumn , Issue 12, 2008, Pages 1841-1844

  De Castro, Kathlia A ^a   Rhee, Hakjune ^a  

^a Hanyang University   (South Korea)

Author keywords

Diol; Drugs; Friedel Crafts alkylation; Nucleophilic substitution; Selective sulfonation

Indexed keywords

ALKYLATION; CHEMICAL REACTIONS; INORGANIC ACIDS;

FRIEDEL-CRAFTS ALKYLATION; PERCHLORIC ACIDS; PRIMARY ALCOHOLS; SYNTHESIS (OF CHIRAL IONIC LIQUIDS); TOLTERODINE;

HYDROCARBONS;

1 PHENYLPROPANE 1,3 DIOL; 4 NITROBENZENESULFONYL CHLORIDE; ALCOHOL DERIVATIVE; DIISOPROPYLAMINE; NITROBENZENE DERIVATIVE; PERCHLORIC ACID; TOLTERODINE;

ARTICLE; CATALYSIS; CHLORINATION; DEPROTECTION REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; FRIEDEL CRAFTS REACTION; REACTION ANALYSIS; REPRODUCIBILITY; SULFONATION;

EID: 46649084036     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1067084     Document Type: Article

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