Death-associated protein 5 (DAP5/p97/NAT1) contributes to retinoic acid-induced granulocytic differentiation and arsenic trioxide-induced apoptosis in acute promyelocytic leukemia

Apoptosis

Volumn 13, Issue 7, 2008, Pages 915-928

  Ozpolat, Bulent ^a   Akar, Ugur ^a   Zorrilla Calancha, Isabel ^a   Vivas Mejia, Pablo ^a   Acevedo Alvarez, Marian ^a   Lopez Berestein, Gabriel ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Acute promyelocytic leukemia; All trans retinoic acid; Apoptosis; Arsenic trioxide; DAP5; DAP5 p97; Differentiation; Leukemia; Retinoic acid

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ARSENIC TRIOXIDE; CALCITRIOL; DIMETHYL SULFOXIDE; MAMMALIAN TARGET OF RAPAMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN P97; RETINOIC ACID;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; GENE EXPRESSION; GRANULOCYTE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ARSENICALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINE, TUMOR; EUKARYOTIC INITIATION FACTOR-2; EUKARYOTIC INITIATION FACTOR-4G; GRANULOCYTES; HL-60 CELLS; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MODELS, BIOLOGICAL; OXIDES; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; TRETINOIN; UP-REGULATION;

EID: 46549088588     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-008-0222-9     Document Type: Article

References (74)

1. Lwenberg B, Downing JR, Burnett A (1999) Acute myeloid leukemia. N Engl J Med 341:1051-1062
2. Bennett JM, Young ML, Andersen JW, Cassileth PA, Tallman MS, Paetta E et al (1999) Long-term survival in acute myeloid leukemia: the Eastern Cooperative Oncology Group experience. Cancer 80(11 suppl):2205-2209
3. Melnick A, Licht JD (1999) Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood 93:3167-3215
4. Breitman TR, Collins SJ, Keene BR (1981) Terminal differentiation of human promyelocytic leukemic cells in primary culture in response to retinoic acid. Blood 57:1000-1004
5. Lanotte M, Martin-Thouvenin V, Najman S, Balerini P, Valensi F, Berger R (1991) NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood 77(5):1080-1086
6. Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhoa L et al (1988) Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72:567-572
7. Fenaux P, Le Deley MC, Castaigne S et al (1993) Effect of all-trans retinoic acid in newly diagnosed acute promyelocytic leukemia: results of a multicenter randomized trial. European APL 91 Group. Blood 82:3241-3249
8. Tallman MS, Andersen JW, Schiffer CA et al (2002) All-trans retinoic acid in acute promyelocytic leukemia: long-term outcome and prognostic factor analysis from the North American Intergroup protocol. Blood 100:4298-4302
9. Altucci L, Gronemeyer H (2001) The promise of retinoids to fight against cancer. Nat Rev Cancer 1(3):181-193
10. Warrell RP Jr, Frankel SR, Miller WH Jr et al (1991) Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med 324:1385-1393
11. Chomienne C, Ballerini P, Huang M, Cornic Chomienne C, Fenaux P, Degos L (1996) Retinoid differentiation therapy in promyelocytic leukemia. FASEB J 10:1025-1030
12. Mathews V, George B, Lakshmi KM, Viswabandya A, Bajel A, Balasubramanian P et al (2006) Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: durable remissions with minimal toxicity. Blood 107:2627-2632
13. Soignet SL, Maslak P, Wang ZG, Jhanwar S, Calleja E, Dardashti LJ et al (1998) Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide. N Engl J Med 339:1341-1348
14. Gianni M, Koken MH, Chelbi-Alix MK, Benoit G, lanotte, Chen Z et al (1998) Combined arsenic and retinoic acid treatment enhances differentiation and apoptosis. Blood 91:4300-4310
15. Jing Y, Dai J, Chalmers-Redman RM, Tatton WG, Waxman S (1999) Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. Blood 94(6):2102-11
16. Gaboli M, Gandini D, Delva L, Pandolfi PP (1998) Acute promyelocytic leukemia as a model for cross-talk between interferon and retinoic acid pathways: from molecular biology to clinical applications. Leuk Lymphoma 30:11-22
17. Benoit G, Roussel M, Pendino F, Ségal-Bendirdjian E, Lanotte M (2001) Orchestration of multiple arrays of signal cross-talk and combinatorial interactions for maturation and cell death: another vision of t(15;17) preleukemic blast and APL-cell maturation. Oncogene 20(49):7161-777
18. Tsiftoglu AS, Pappas IS, Vizirianakis IS (2003) Mechanisms involved in the induced differentiation of leukemia cells. Pharmacol Ther 100(3):257-290
19. Ward AC, Loeb DM, Soede-Bobok AA, Touw IP, Friedman AD (2000) Regulation of granulopoiesis by transcription factors and cytokine signals. Leukemia 14(6):973-990
20. Casini T, Pelicci PG (1999) A function of p21 during promyelocytic leukemia cell differentiation independent of CDK inhibition and cell cycle arrest. Oncogene 18:3235-3243
21. Meani N, Minardi S, Licciulli S, Gelmetti V, Coco FL, Nervi C et al (2005) Molecular signature of retinoic acid treatment in acute promyelocytic leukemia. Oncogene 24:3358-3368
22. Krichevsky AM, Metzer E, Rosen H (1999) Translational control of specific genes during differentiation of HL-60 cells. J Biol Chem 274:14295-14305
23. Grolleau A, Sonenberg N, Wietzerbi J, Beretta L (1999) Differential regulation of 4E-BP1 and 4E-BP2, two repressors of translation initiation, during human myeloid cell differentiation. J Immunol 162:3491-3497
24. Gerlitz G, Jagus R, Elroy-Stein O (2002) Phosphorylation of initiation factor-2 alpha is required for activation of internal translation initiation during cell differentiation. Eur J Biochem 269(11):2810-2819
25. Zheng PZ, Wang KK et al (2005) Systems analysis of transcriptome and proteome in retinoic acid_arsenic trioxide-induced cell differentiation_apoptosis of promyelocytic leukemia. PNAS 102(21):7653-7658
26. Weber JA, Gay CV (2001) Expression of translation initiation factor IF2 is regulated during osteoblast differentiation. J Cell Biochem 81(4):700-714
27. Rosenwald IB, Rhoads DB, Callanan LD, Isselbacher KJ, Schmidt EV (1993) Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 in response to growth induction by c-myc. Proc Natl Acad Sci USA 90:6175-6178
28. Suzuki T, Koyama Y, Ichikawa H, Tsushima K, Abe K, Hayakawa S et al (2005) 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells. Cell Struct Funct 30:1-6
29. Pain VM (1996) Initiation of protein synthesis in eukaryotic cells. Eur J Biochem 236:747-771
30. Rosenwald IB (1996) Upregulatation expression of the genes encoding translation initiation factors eIF-4E and eIF-2alpha in transformed cells. Cancer Lett 102:113-123
31. Willis A (1999) Translational control of growth factor and proto-oncogene expression. Int J Biochem Cell Biol 31:73-86
32. Brostrom CO, Brostrom MA (1998) Regulation of translational initiation during cellular responses to stress. Prog Nucleic Acid Res Mol Biol 58:79-125
33. Clemens MJ (2001) Initiation factor eIF2alpha phosphorylation in stress responses and apoptosis. Prog Mol Subcell Biol 27:57-89
34. Clemens MJ (2004) Targets and mechanisms for the regulation of translation in malignant transformation. Oncogene 23(18):3180-3188
35. Perrotti D, Calabretta B (2002) Post-transcriptional mechanisms in BCR/ABL leukemogenesis: role of shuttling RNA-binding proteins. Oncogene 21:8577-8583
36. Imataka H, Sonenberg N (1997) Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. Mol Cell Biol 17(12):6940-6947
37. Imataka H, Olsen HS, Sonenberg N (1997) A new translational regulator with homology to eukaryotic translation initiation factor 4G. EMBO J 16(4):817-825
38. Yamanaka S, Poksay KS, Arnold KS, Inneraruty TL (1997) A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme. Genes Dev 11(3):321-333
39. Henis-Korenblit S, Strumpf NL, Goldstaub D, Kimchi A (2000) A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation. Mol Cell Biol 20(2):496-506
40. Henis-Korenblit S, Shani G, Sines T, Marash L, Shohat G, Kimchi A (2002) The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins. Proc Natl Acad Sci USA 99(8):5400
41. Marash L, Kimchi A (2005) DAP5 and IRES-mediated translation during programmed cell death. Cell Death Differ 12(6):554-562
42. Nevins TA, Harder ZM, Korneluk RG, Holcik M (2003) Distinct regulation of internal ribosome entry site-mediated translation following cellular stress is mediated by apoptotic fragments of eIF4G translation initiation factor family members eIF4GI and p97/DAP5/NAT1. J Biol Chem 278(6):3572-3579
43. Yamanaka S, Zhang XY, Maeda M, Miura K, Wang S, Farese RV Jr et al (2000) Essential role of NAT1/p97/DAP5 in embriyonic differentiation and the retinoic acid pathway. EMBO J 19:5533-5541
44. Harris MN, Ozpolat B, Abdi F, Gu S, Legler A, Mawuenyega KG et al (2004) Comparative proteomic analysis of all-trans-retinoic acid treatment reveals systematic posttranscriptional control mechanisms in acute promyelocytic leukemia. Blood 104(5):1314-1323
45. Ozpolat B, Akar A, Baria M, Lopez Berestein G. PKCδ regulates eukaryotic Initiation factor eIF2α through PKR during retinoic acid-induced myeloid cell differentiation (submitted)
46. Ozpolat B, Akar U, Steiner M, Zorrilla-Calancha I, Tirado-Gomez M, Colburn N et al (2007) Programmed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells. Mol Cancer Res 5(1):95-108
47. Ozpolat B, Mehta K, Tari A, Lopez-Berestein G (2002) All-trans-retinoic acid-induced expression and regulation of retinoic acid 4-hydroxylase (CYP26) in human promyelocytic leukemia. Am J Hematol 70:39-47
48. Diaz B, Lopez-Berestein G (2000) A distinct element involved in lipopolysaccharide activation of the tumor necrosis factor-alpha promoter in monocytes. J Interferon Cytokine Res 20:741-748
49. Cai X, Shen YL, Zhu Q, Jia PM, Yu Y, Zhou L et al (2000) Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. Leukemia 14:262-270
50. Jing Y, Wang L, Xia L, Chen GQ, Miller WH, Waxman S (2001) Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo. Blood 97(1):264-269
51. Dever TE (2002) Gene specific regulation of by general transcription factors. Cell 108:545-556
52. Donze O, Jagus R, Koromilas AE, Hershey JWB, Sonenberg N (1995) Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells. EMBO J 14:3828-3834
53. Lazaris-Karatzas A, Montine KS, Sonenberg N (1990) Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap. Nature 345:544-547
54. DeBenedetti A, Rhoads RE (1990) Overexpression of eIF-4E in HeLa cells results in aberrant growth and morphology. Proc Natl Acad Sci USA 87:8212-8216
55. De Benedetti A, Harris A (1999) eIF4E expression in tumors: its possible role in progression of malignancies. Int J Biochem Cell Biol 31(1):59-72
56. Fukuchi-Shimogori T, Ishii I, Kashiwagi KHM, Ekimoto H, Igarashi K (1997) Malignant transformation by overproduction of translation initiation factor eIF4G. Cancer Res 57:5041-5044
57. Clemens MJ, Bommer UA (1999) Translational control: the cancer connection. Int J Biochem Cell Biol 31:1-23
58. Rosenwald IB (1996) Upregulated expression of the genes encoding translation initiation factors eIF-4E and eIF-2alpha in transformed cells. Cancer Lett 102:113-123
59. Shen ZX, Shi ZZ, Fang J, Gu BW, Li JM, Zhu YM et al (2004) All-trans retinoic acid/ATO combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci USA 101(15):5328-5335
60. Bhatia M, Kirkland JB, Meckling-Gill KA (1994) M-CSF and 1,25 dihydroxy vitamin D3 synergize with 12-O-tetradecanoylphorbol-13-acetate to induce macrophage differentiation in acute promyelocytic leukemia NB4 cells. Leukemia 8(10):1744-1751
61. Collins SJ, Russeti FW, Gallander RE, Gallo RC (1978) Terminal differentiation of human promyelocytic leukemia cells induced by dimethylsulfoxide (DMSO) and other polar solvents. Proc Natl Acad Sci USA 75:2458-2462
62. Ahmed N, Williams JF, Weidemann MJ (1991) The human promyelocytic HL60 cell line: a model of myeloid differentiation using dimethylsulphoxide, phorbol ester and butyrate. Biochem Int 23:591-602
63. Khanna-Gupta A, Kolibaba K, Zibello TA, Berliner N (1994) NB4 cells show bilineage potential and an aberrant pattern of neutrophil secondary granule protein gene expression. Blood 84(1):294-302
64. Drach J, Lopez-Berestein G, McQueen T, Andreeff M, Mehta K (1993) Induction of differentiation in myeloid leukemia cell lines and acute promyelocytic leukemia cells by liposomal all-trans-retinoic acid. Cancer Res (9):2100-2104
65. Mehta K, Lopez-Berestein G (1986) Expression of tissue transglutaminase in cultured monocytic leukemia (THP-1) cells during differentiation. Cancer Res 46(3):1388-1394
66. Ruggero D, Soneneberg N (2005) Akt and translational control 24(50):7426-7434
67. Ozpolat B, Lopez-Berestein G, Mehta K (2001) ATRA(ouble) in the treatment of acute promyelocytic leukemia. J Biol Reg Homeostat Agents 15:107-122
68. Topisirovic I, Guzman ML, McConnell MJ, Licht JD, Culjkovic B, Neering SJ et al (2003) Aberrant eIF4E dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis. Mol Cell Biol 24:8992-9002
69. Yang HS, Jansen AP, Komar AA, Zheng X, Merrick WC, Costes S, Lockett SJ, Sonenberg N, Colburn NC (2003) The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4a binding protein that inhibits translation. Mol Cel Biol 23(1):26-37
70. Iborra J, Jackson DA, Cook PR (2001) Coupled transcription and translation within nuclei of mammalian cells. Science 293:1139-1142
71. Cmarik JL, Min H, Hegamyer G, Zhan S, Kulesz-Martin M, Yoshinaga H et al (1999) Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation. Proc Natl Acad Sci USA 96:14037-14042
72. Lai HK, Borden KL (2000) The promyelocytic leukemia (PML) protein suppresses cyclin D1 protein production by altering the nuclear cytoplasmic distribution of cyclin D1 mRNA. Oncogene 19(13):1623-1634
73. Zhong S, Salomoni P, Pandolfi PP (2000) The transcriptional role of PML and the nuclear body. Nat Cell Biol 2(5):E85-E90
74. Meric F, Hunt KK (2002) Translation initiation in cancer: a novel target for therapy. Mol Cancer Ther 1:971-979