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Volumn 87, Issue 3, 2008, Pages 331-338

Enhanced local tumour control after single or fractionated radiation treatment using the hypoxic cell radiosensitizer doranidazole

Author keywords

C3H mouse mammary carcinoma; Doranidazole; Radiation sensitizer; Skin damage

Indexed keywords

ANTINEOPLASTIC AGENT; DORANIDAZOLE;

EID: 46549085948     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2008.03.002     Document Type: Article
Times cited : (20)

References (44)
  • 1
    • 0021276479 scopus 로고
    • Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data
    • Moulder J.E., and Rockwell S. Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data. Int J Radiat Oncol Biol Phys 10 (1984) 695-712
    • (1984) Int J Radiat Oncol Biol Phys , vol.10 , pp. 695-712
    • Moulder, J.E.1    Rockwell, S.2
  • 2
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review
    • Vaupel P., Kallinowski F., and Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49 (1989) 6449-6465
    • (1989) Cancer Res , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 3
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hoeckel M., Schlenger K., Aral B., Mitze M., Schaffer U., and Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56 (1996) 4509-4515
    • (1996) Cancer Res , vol.56 , pp. 4509-4515
    • Hoeckel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 4
    • 0029955072 scopus 로고    scopus 로고
    • Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
    • Nordsmark M., Overgaard M., and Overgaard J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 41 (1996) 31-39
    • (1996) Radiother Oncol , vol.41 , pp. 31-39
    • Nordsmark, M.1    Overgaard, M.2    Overgaard, J.3
  • 6
    • 0009829245 scopus 로고    scopus 로고
    • Dose response modifiers in radiation therapy
    • Gunderson L.L., and Tepper J.E. (Eds), Churchill Livingstone, New York
    • Horsman M.R., Lindegaard J.C., Grau C., Nordsmark M., and Overgaard J. Dose response modifiers in radiation therapy. In: Gunderson L.L., and Tepper J.E. (Eds). Clinical radiation oncology (2007), Churchill Livingstone, New York 59-73
    • (2007) Clinical radiation oncology , pp. 59-73
    • Horsman, M.R.1    Lindegaard, J.C.2    Grau, C.3    Nordsmark, M.4    Overgaard, J.5
  • 7
    • 0024384825 scopus 로고
    • Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx. Final report from the DAHANCA 2 study
    • Overgaard J., Hansen H.S., Andersen A.P., Hjelm-Hansen M., Jorgensen K., Sandberg E., et al. Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx. Final report from the DAHANCA 2 study. Int J Radiat Oncol Biol Phys 16 (1989) 1065-1068
    • (1989) Int J Radiat Oncol Biol Phys , vol.16 , pp. 1065-1068
    • Overgaard, J.1    Hansen, H.S.2    Andersen, A.P.3    Hjelm-Hansen, M.4    Jorgensen, K.5    Sandberg, E.6
  • 8
    • 0031909654 scopus 로고    scopus 로고
    • A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85
    • Overgaard J., Hansen H.S., Overgaard M., Bastholt L., Berthelsen A., Specht L., et al. A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol 46 (1998) 135-146
    • (1998) Radiother Oncol , vol.46 , pp. 135-146
    • Overgaard, J.1    Hansen, H.S.2    Overgaard, M.3    Bastholt, L.4    Berthelsen, A.5    Specht, L.6
  • 9
    • 0020405282 scopus 로고
    • A comparative investigation of nimorazole and misonidazole as hypoxic radiosensitizers in a C3H mammary carcinoma in vivo
    • Overgaard J., Overgaard M., Nielsen O.S., Pedersen A.K., and Timothy A.R. A comparative investigation of nimorazole and misonidazole as hypoxic radiosensitizers in a C3H mammary carcinoma in vivo. Br J Cancer 46 (1982) 904-911
    • (1982) Br J Cancer , vol.46 , pp. 904-911
    • Overgaard, J.1    Overgaard, M.2    Nielsen, O.S.3    Pedersen, A.K.4    Timothy, A.R.5
  • 10
    • 34748860952 scopus 로고    scopus 로고
    • Hypoxic radiosensitization: adored and ignored
    • Overgaard J. Hypoxic radiosensitization: adored and ignored. J Clin Oncol 25 (2007) 4066-4074
    • (2007) J Clin Oncol , vol.25 , pp. 4066-4074
    • Overgaard, J.1
  • 12
    • 33846224376 scopus 로고    scopus 로고
    • AK-2123 (sanazol) as a radiation sensitizer in the treatment of stage III cervical cancer: results of an IAEA multicentre randomized trial
    • Dobrowsky W., Huigol N.G., Jayatilake R.S., Kizilbash N.I.A., Okkan S., Kagiya V.T., et al. AK-2123 (sanazol) as a radiation sensitizer in the treatment of stage III cervical cancer: results of an IAEA multicentre randomized trial. Radiother Oncol 82 (2007) 24-29
    • (2007) Radiother Oncol , vol.82 , pp. 24-29
    • Dobrowsky, W.1    Huigol, N.G.2    Jayatilake, R.S.3    Kizilbash, N.I.A.4    Okkan, S.5    Kagiya, V.T.6
  • 13
    • 0027177156 scopus 로고
    • Radiosensitization by a new potent nucleoside analog: 1-(1′,3′,4′-trihydroxy-2′-butoxy)methyl-2-nitroimidazole(RP-343)
    • Murayama C., Suzuki A., Sato C., Tanabe Y., Shoji T., Miyata Y., et al. Radiosensitization by a new potent nucleoside analog: 1-(1′,3′,4′-trihydroxy-2′-butoxy)methyl-2-nitroimidazole(RP-343). Int J Radiat Oncol Biol Phys 26 (1993) 433-443
    • (1993) Int J Radiat Oncol Biol Phys , vol.26 , pp. 433-443
    • Murayama, C.1    Suzuki, A.2    Sato, C.3    Tanabe, Y.4    Shoji, T.5    Miyata, Y.6
  • 14
    • 0029144507 scopus 로고
    • Optical isomers of a new 2-nitroimidazole nucleoside analog (PR-350 series): radiosensitization efficiency and toxicity
    • Oya N., Shibamoto Y., Sasai K., Shibata T., Murata R., Takagi T., et al. Optical isomers of a new 2-nitroimidazole nucleoside analog (PR-350 series): radiosensitization efficiency and toxicity. Int J Radiat Oncol Biol Phys 33 (1995) 119-127
    • (1995) Int J Radiat Oncol Biol Phys , vol.33 , pp. 119-127
    • Oya, N.1    Shibamoto, Y.2    Sasai, K.3    Shibata, T.4    Murata, R.5    Takagi, T.6
  • 15
    • 0034254436 scopus 로고    scopus 로고
    • Radiosensitivity of human pancreatic cancer cells in vitro and in vivo, and the effect of a new hypoxic cell sensitizer, doranidazole
    • Shibamoto Y., Kubota T., Kishii K., and Tsujitani M. Radiosensitivity of human pancreatic cancer cells in vitro and in vivo, and the effect of a new hypoxic cell sensitizer, doranidazole. Radiother Oncol 56 (2000) 265-270
    • (2000) Radiother Oncol , vol.56 , pp. 265-270
    • Shibamoto, Y.1    Kubota, T.2    Kishii, K.3    Tsujitani, M.4
  • 16
    • 0034018562 scopus 로고    scopus 로고
    • PR-000350, a novel hypoxic radiosensitizer, enhances tumor cell killing by promoting apoptosis preferentially in the S-phase fraction
    • Kuno Y., and Shinomiya N. PR-000350, a novel hypoxic radiosensitizer, enhances tumor cell killing by promoting apoptosis preferentially in the S-phase fraction. Apoptosis 5 (2000) 69-77
    • (2000) Apoptosis , vol.5 , pp. 69-77
    • Kuno, Y.1    Shinomiya, N.2
  • 17
    • 0036616247 scopus 로고    scopus 로고
    • Effect of a hypoxic cell sensitizer doranidazole on the radiation-induced apoptosis of mouse L5178Y lymphoma cells
    • Aoki M., Furusawa Y., Shibamoto Y., Kobayashi A., and Tsujitani M. Effect of a hypoxic cell sensitizer doranidazole on the radiation-induced apoptosis of mouse L5178Y lymphoma cells. J Radiat Res 43 (2002) 161-166
    • (2002) J Radiat Res , vol.43 , pp. 161-166
    • Aoki, M.1    Furusawa, Y.2    Shibamoto, Y.3    Kobayashi, A.4    Tsujitani, M.5
  • 18
    • 0036515645 scopus 로고    scopus 로고
    • A nitroimidazole derivative, PR-350, enhances the killing of pancreatic cancer cells exposed to high-dose irradiation under hypoxia
    • Mizumoto K., Qian L.W., Zhang L., Nagai E., Kura S., and Tanaka M. A nitroimidazole derivative, PR-350, enhances the killing of pancreatic cancer cells exposed to high-dose irradiation under hypoxia. J Radiat Res 43 (2002) 43-51
    • (2002) J Radiat Res , vol.43 , pp. 43-51
    • Mizumoto, K.1    Qian, L.W.2    Zhang, L.3    Nagai, E.4    Kura, S.5    Tanaka, M.6
  • 19
    • 27744520254 scopus 로고    scopus 로고
    • Effects of hypoxic cell radiosensitizer doranidazole (PR-350) on the radioresponse of murine and human tumor cells in vitro and in vivo
    • Yahiro T., Masui S., Kubota N., Yamada K., Kobayashi A., and Kishii K. Effects of hypoxic cell radiosensitizer doranidazole (PR-350) on the radioresponse of murine and human tumor cells in vitro and in vivo. J Radiat Res 46 (2005) 363-372
    • (2005) J Radiat Res , vol.46 , pp. 363-372
    • Yahiro, T.1    Masui, S.2    Kubota, N.3    Yamada, K.4    Kobayashi, A.5    Kishii, K.6
  • 20
    • 0032787541 scopus 로고    scopus 로고
    • In vivo study of radiosensitizing effect of hypoxic cell radiosensitizer PR-350 on a human small cell lung cancer
    • Suzuki Y., Hasegawa M., Hayakawa K., Mitsuhashi N., and Niibe H. In vivo study of radiosensitizing effect of hypoxic cell radiosensitizer PR-350 on a human small cell lung cancer. Anticancer Res 19 (1999) 3993-4000
    • (1999) Anticancer Res , vol.19 , pp. 3993-4000
    • Suzuki, Y.1    Hasegawa, M.2    Hayakawa, K.3    Mitsuhashi, N.4    Niibe, H.5
  • 21
    • 0033631315 scopus 로고    scopus 로고
    • In vivo efficacy and pharmacokinetics of a new hypoxic cell radiosensitizer doranidazole in SUIT-2 human pancreatic cancer xenografted in mouse pancreas
    • Matsuoka H., Shibamoto Y., Kubota T., Tsujitani M., and Majima T. In vivo efficacy and pharmacokinetics of a new hypoxic cell radiosensitizer doranidazole in SUIT-2 human pancreatic cancer xenografted in mouse pancreas. Oncol Rep 7 (2000) 23-26
    • (2000) Oncol Rep , vol.7 , pp. 23-26
    • Matsuoka, H.1    Shibamoto, Y.2    Kubota, T.3    Tsujitani, M.4    Majima, T.5
  • 22
    • 0035122495 scopus 로고    scopus 로고
    • Phase Ia study of a hypoxic cell sensitizer doranidazole (PR-350) in combination with conventional radiotherapy
    • Nemoto K., Shibamoto Y., Ohmagari J., Baba Y., Ebe K., Ariga H., et al. Phase Ia study of a hypoxic cell sensitizer doranidazole (PR-350) in combination with conventional radiotherapy. Anticancer Drugs 12 (2001) 1-6
    • (2001) Anticancer Drugs , vol.12 , pp. 1-6
    • Nemoto, K.1    Shibamoto, Y.2    Ohmagari, J.3    Baba, Y.4    Ebe, K.5    Ariga, H.6
  • 23
    • 1842587450 scopus 로고    scopus 로고
    • PR-350 study group. Phase III trial of radiosensitizer PR-350 combined with intraoperative radiotherapy for the treatment of locally advanced pancreatic cancer
    • Sunamura M., Karasawa K., Okamoto A., Ogata Y., Nemoto K., Hosotani R., et al. PR-350 study group. Phase III trial of radiosensitizer PR-350 combined with intraoperative radiotherapy for the treatment of locally advanced pancreatic cancer. Pancreas 28 (2004) 330-334
    • (2004) Pancreas , vol.28 , pp. 330-334
    • Sunamura, M.1    Karasawa, K.2    Okamoto, A.3    Ogata, Y.4    Nemoto, K.5    Hosotani, R.6
  • 24
    • 46549089743 scopus 로고    scopus 로고
    • Efficacy of novel hypoxic cell sensitizer doranidazole in the treatment of locally advanced pancreatic cancer - long-term results of a placebo-controlled randomised study
    • Karasawa K., Sunamura M., Okamoto A., Nemoto K., Matsuno S., Nishimura Y., et al. Efficacy of novel hypoxic cell sensitizer doranidazole in the treatment of locally advanced pancreatic cancer - long-term results of a placebo-controlled randomised study. Radiother Oncol 87 (2008) 326-330
    • (2008) Radiother Oncol , vol.87 , pp. 326-330
    • Karasawa, K.1    Sunamura, M.2    Okamoto, A.3    Nemoto, K.4    Matsuno, S.5    Nishimura, Y.6
  • 25
    • 0019208702 scopus 로고
    • Simultaneous and sequential hyperthermia and radiation treatment of an experimental tumor and its surrounding normal tissue in vivo
    • Overgaard J. Simultaneous and sequential hyperthermia and radiation treatment of an experimental tumor and its surrounding normal tissue in vivo. Int J Radiat Oncol Biol Phys 6 (1980) 1507-1517
    • (1980) Int J Radiat Oncol Biol Phys , vol.6 , pp. 1507-1517
    • Overgaard, J.1
  • 26
    • 0025685602 scopus 로고
    • Combination of nicotinamide and hyperthermia to eliminate radioresistant chronically and acutely hypoxic tumour cells
    • Horsman M.R., Chaplin D.J., and Overgaard J. Combination of nicotinamide and hyperthermia to eliminate radioresistant chronically and acutely hypoxic tumour cells. Cancer Res 50 (1990) 7430-7436
    • (1990) Cancer Res , vol.50 , pp. 7430-7436
    • Horsman, M.R.1    Chaplin, D.J.2    Overgaard, J.3
  • 27
    • 0032801526 scopus 로고    scopus 로고
    • Comparisons among pimonidazole binding, oxygen electrode measurements and radiation response in C3H mouse tumors
    • Raleigh J.A., Chou S.C., Arteel G.E., and Horsman M.R. Comparisons among pimonidazole binding, oxygen electrode measurements and radiation response in C3H mouse tumors. Radiat Res 151 (1999) 580-589
    • (1999) Radiat Res , vol.151 , pp. 580-589
    • Raleigh, J.A.1    Chou, S.C.2    Arteel, G.E.3    Horsman, M.R.4
  • 28
  • 29
    • 0026608048 scopus 로고
    • Improving the radiation response in a C3H mouse mammary carcinoma by normobaric oxygen or carbogen breathing
    • Grau C., Horsman M.R., and Overgaard J. Improving the radiation response in a C3H mouse mammary carcinoma by normobaric oxygen or carbogen breathing. Int J Radiat Oncol Biol Phys 22 (1992) 415-419
    • (1992) Int J Radiat Oncol Biol Phys , vol.22 , pp. 415-419
    • Grau, C.1    Horsman, M.R.2    Overgaard, J.3
  • 30
    • 1942439092 scopus 로고    scopus 로고
    • Preclinical studies on how to deal with patient intolerance to nicotinamide and carbogen
    • Horsman M.R., and Overgaard J. Preclinical studies on how to deal with patient intolerance to nicotinamide and carbogen. Radiother Oncol 70 (2004) 301-309
    • (2004) Radiother Oncol , vol.70 , pp. 301-309
    • Horsman, M.R.1    Overgaard, J.2
  • 31
    • 0018119470 scopus 로고
    • Care with radiosensitizers
    • Hendry J.H., and Sutton M.L. Care with radiosensitizers. Br J Radiol 51 (1978) 927-928
    • (1978) Br J Radiol , vol.51 , pp. 927-928
    • Hendry, J.H.1    Sutton, M.L.2
  • 32
    • 0018576592 scopus 로고
    • Quantitation of the radiotherapeutic importance of naturally-hypoxic normal tissues from collated experiments with rodents using single doses
    • Hendry J.H. Quantitation of the radiotherapeutic importance of naturally-hypoxic normal tissues from collated experiments with rodents using single doses. Int J Radiat Oncol Biol Phys 5 (1979) 971-976
    • (1979) Int J Radiat Oncol Biol Phys , vol.5 , pp. 971-976
    • Hendry, J.H.1
  • 33
    • 46549089134 scopus 로고    scopus 로고
    • Timothy AR, Overgaard J. In-vivo radiosensitisation by nimorazole and hyperthermia. In: Overgaard J, editor. Hyperthermic oncology 1984, volume 1. Summary papers. London: Taylor and Francis; 1984. p. 309-10.
    • Timothy AR, Overgaard J. In-vivo radiosensitisation by nimorazole and hyperthermia. In: Overgaard J, editor. Hyperthermic oncology 1984, volume 1. Summary papers. London: Taylor and Francis; 1984. p. 309-10.
  • 34
    • 0026592629 scopus 로고
    • Interaction of misonidazole, hyperthermia, and irradiation in a C3H mammary carcinoma and its surrounding skin in vivo
    • Mao H.S., Grau C., and Overgaard J. Interaction of misonidazole, hyperthermia, and irradiation in a C3H mammary carcinoma and its surrounding skin in vivo. Int J Radiat Oncol Biol Phys 22 (1991) 115-122
    • (1991) Int J Radiat Oncol Biol Phys , vol.22 , pp. 115-122
    • Mao, H.S.1    Grau, C.2    Overgaard, J.3
  • 35
    • 0019189032 scopus 로고
    • Testing of hypoxic cell radiosensitizers in vivo
    • Denekamp J. Testing of hypoxic cell radiosensitizers in vivo. Cancer Clin Trials 3 (1980) 139-148
    • (1980) Cancer Clin Trials , vol.3 , pp. 139-148
    • Denekamp, J.1
  • 36
    • 0019993528 scopus 로고
    • Skin sensitisation by misonidazole: a demonstration of uniform mild hypoxia
    • Stewart F.A., Denekamp J., and Randhawa V.S. Skin sensitisation by misonidazole: a demonstration of uniform mild hypoxia. Br J Cancer 45 (1982) 869-877
    • (1982) Br J Cancer , vol.45 , pp. 869-877
    • Stewart, F.A.1    Denekamp, J.2    Randhawa, V.S.3
  • 37
    • 0031281939 scopus 로고    scopus 로고
    • Nicotinamide as a radiosensitizer in tumours and normal tissues: the importance of drug dose and timing
    • Horsman M.R., Siemann D.W., Chaplin D.J., and Overgaard J. Nicotinamide as a radiosensitizer in tumours and normal tissues: the importance of drug dose and timing. Radiother Oncol 45 (1997) 167-174
    • (1997) Radiother Oncol , vol.45 , pp. 167-174
    • Horsman, M.R.1    Siemann, D.W.2    Chaplin, D.J.3    Overgaard, J.4
  • 38
    • 0034962379 scopus 로고    scopus 로고
    • Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumours
    • Murata R., Siemann D.W., Overgaard J., and Horsman M.R. Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumours. Radiother Oncol 60 (2001) 155-161
    • (2001) Radiother Oncol , vol.60 , pp. 155-161
    • Murata, R.1    Siemann, D.W.2    Overgaard, J.3    Horsman, M.R.4
  • 39
    • 0022471797 scopus 로고
    • Sensitizers and radiation dose fractionation: results and interpretations
    • Hill R.P. Sensitizers and radiation dose fractionation: results and interpretations. Int J Radiat Oncol Biol Phys 12 (1986) 1049-1054
    • (1986) Int J Radiat Oncol Biol Phys , vol.12 , pp. 1049-1054
    • Hill, R.P.1
  • 40
    • 0029034635 scopus 로고
    • Reoxygenation in a C3H mouse mammary carcinoma: the importance of chronic rather than acute hypoxia
    • Horsman M.R., Grau C., and Overgaard J. Reoxygenation in a C3H mouse mammary carcinoma: the importance of chronic rather than acute hypoxia. Acta Oncol 34 (1995) 325-328
    • (1995) Acta Oncol , vol.34 , pp. 325-328
    • Horsman, M.R.1    Grau, C.2    Overgaard, J.3
  • 41
    • 34548672366 scopus 로고    scopus 로고
    • Phase I/II trial of sequential chemotherapy using a novel hypoxic cell radiosensitizer, doranidazole (PR-350), in patients with locally advanced non-small-cell lung cancer (WJTOG-0002)
    • Nishimura Y., Nakagawa K., Takeda K., Tanaka M., Segawa Y., Tsujino K., et al. Phase I/II trial of sequential chemotherapy using a novel hypoxic cell radiosensitizer, doranidazole (PR-350), in patients with locally advanced non-small-cell lung cancer (WJTOG-0002). Int J Radiat Oncol Biol Phys 69 (2007) 786-792
    • (2007) Int J Radiat Oncol Biol Phys , vol.69 , pp. 786-792
    • Nishimura, Y.1    Nakagawa, K.2    Takeda, K.3    Tanaka, M.4    Segawa, Y.5    Tsujino, K.6
  • 42
    • 0028632781 scopus 로고
    • Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors
    • Overgaard J. Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors. Oncol Res 6 (1994) 509-518
    • (1994) Oncol Res , vol.6 , pp. 509-518
    • Overgaard, J.1
  • 44
    • 0029066473 scopus 로고
    • Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole (SR-2508) with radiotherapy alone for locally advanced head and neck carcinomas
    • Lee D.-J., Cosmatos D., Marcial V.A., Fu K.K., Rotman M., Cooper J.S., et al. Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole (SR-2508) with radiotherapy alone for locally advanced head and neck carcinomas. Int J Radiat Oncol Biol Phys 32 (1995) 567-576
    • (1995) Int J Radiat Oncol Biol Phys , vol.32 , pp. 567-576
    • Lee, D.-J.1    Cosmatos, D.2    Marcial, V.A.3    Fu, K.K.4    Rotman, M.5    Cooper, J.S.6


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