Development of structure lipid bilayer permeability relationships for peptide-like small organic molecules

Molecular Pharmaceutics

Volumn 5, Issue 3, 2008, Pages 371-388

  Cao, Yichen ^a   Xiang, Tian Xiang ^a   Anderson, Bradley D ^a,b  

^a University of Kentucky   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Computational methods; Drug absorption; Linear free energy relationships; Lipid bilayer permeability; Membrane transport; Partition coefficients; Peptides

Indexed keywords

2 (ACETYLAMINO) N,N DIMETHYLACETAMIDE; 2 AMINO N METHYLACETAMIDE; 2 AMINO N,N DIMETHYLACETAMIDE; 4 TOLYLACETIC ACID METHYL ESTER; [2 (4 TOLYL)ACETYLAMINO]ACETIC ACID METHYL ESTER; [[(4 METHYLPHENYL)ACETYL]AMINO]ACETIC ACID; ACETAMIDE DERIVATIVE; ACETIC ACID; ALANINE; CARBAMIC ACID DERIVATIVE; DECADIENE; DIOLEOYLPHOSPHATIDYLCHOLINE; DIPEPTIDE; GLYCINE; METHYL (ACETYLAMINO)ACETATE; METHYL ACETATE; N METHYL 2 (4 TOLYL)ACETAMIDE; N METHYLCARBAMOYLMETHYL 2 (4 TOLYL)ACETAMIDE; N,N DIMETHYL 2 (4 TOLYL)ACETAMIDE; N,N DIMETHYLACETAMIDE; N,N DIMETHYLCARBAMOYLMETHYL 2 (4 TOLYL)ACETAMIDE; OCTANOL; ORGANIC SOLVENT; PEPTIDE; PHENYLACETIC ACID DERIVATIVE; SARCOSINE; TERT BUTYL [2 (DIMETHYLAMINO) 2 OXOETHYL]CARBAMATE; TRIPEPTIDE; UNINDEXED DRUG; WATER;

ARTICLE; CARBOXY TERMINAL SEQUENCE; DRUG ABSORPTION; ENERGY; HYDROGEN BOND; LIPID BILAYER; MEMBRANE PERMEABILITY; MEMBRANE TRANSPORT; MOLECULAR SIZE; PARTITION COEFFICIENT; PRIORITY JOURNAL;

GLYCINE; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; LIPID BILAYERS; MODELS, CHEMICAL; PEPTIDES; PERMEABILITY; PHOSPHATIDYLCHOLINES; PROTEIN TRANSPORT; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; WATER;

EID: 46449136063     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp700100n     Document Type: Article

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