Serum parathyroid hormone is associated with increased mortality independent of 25-hydroxy vitamin D status, bone mass, and renal function in the frail and very old: A cohort study

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 11, 2004, Pages 5477-5481

  Sambrook, P N ^a,b   Chen, J S ^a   March, L M ^a   Cameron, I D ^a   Cumming, R G ^a   Lord, S R ^a   Schwarz, J ^a   Seibel, M J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ROYAL NORTH SHORE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; PARATHYROID HORMONE;

ADULT; AGED; ARTICLE; AUSTRALIA; BONE MASS; COHORT ANALYSIS; FEMALE; FOLLOW UP; HEALTH STATUS; HUMAN; HYPERPARATHYROIDISM; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIVARIATE ANALYSIS; NUTRITIONAL STATUS; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; PROSPECTIVE STUDY; VITAMIN D DEFICIENCY;

AGED; AGED, 80 AND OVER; BONE DENSITY; COHORT STUDIES; FEMALE; FRAIL ELDERLY; HUMANS; KIDNEY; MALE; PARATHYROID HORMONE; VITAMIN D;

EID: 8744246381     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-0307     Document Type: Article

References (40)

1. Cooper C, Atkins EJ, Jaconsen SJ, O'Fallon WM, Melton LJ 1993 Population based study of survival after osteoporotic fractures. Am J Epidemiol 137:1001-1005
2. Center JR, Nguyen TV, Schneider D, Sambrook PN, Eisman JA 1999 Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 353:878-882
3. Browner WS, Seeley, DG, Vogt TM, Cummings SR 1991 Non trauma mortality in elderly women with low bone mineral density. Lancet 338:355-358
4. Johansson C, Black D, Johnell O, Oden A, Mellstrom D 1998 Bone mineral density is a predictor of survival. Calcif Tissue Int 63:190-196
5. Von der Recke P, Hansen MA, Hassager C 1999 The association between low bone mass at the menopause and cardiovascular mortality. Am J Med 106:273-278
6. Trivedi DP, Khaw KT 2001 Bone mineral density at the hip predicts mortality in elderly men. Osteoporos Int 12:259-265
7. Palmer M, Adami HO, Bergstrom R, Jakobsson S, Akerstrom G, Ljunghall S 1987 Survival and renal function in untreated hypercalcaemia: population based cohort study with 14 years of follow-up. Lancet 1:59-62
8. Palmer M, Adami HO, Bergstrom R, Akerstrom G, Ljunghall S 1987 Mortality after surgery for primary hyperparathyroidism: a follow-up of 441 patients operated on from 1956 to 1979. Surgery 102:1-7
9. Hedback G, Oden A 1998 Increased risk of death from primary hyperparathyroidism: an update. Eur J Clin Invest 28:271-276
10. Lundgren E, Lind L, Palmer M, Jakobsson S, Ljunghall S, Rastad J 2001 Increased cardiovascular mortality and normalized serum calcium in patients with mild hypercalcemia followed up for 25 years. Surgery 130:978-985
11. Nilsson IL, Yin L, Lundgren E, Rastad J, Ekbom A 2002 Clinical presentation of primary hyperparathyroidism in Europe: nationwide cohort analysis on mortality from nonmalignant causes. J Bone Miner Res 17(Suppl 2):N68-N74
12. Soreide JA, van Heerden JA, Grant CS, Yau Lo C, Schleck C, Ilstrup DM 1997 Survival after surgical treatment for primary hyperparathyroidism. Surgery 122:1117-1123
13. Wermers RA, Khosla S, Atkinson EJ, Grant CS, Hodgson SF, O'Fallon WM, Melton LJ 1998 Survival after the diagnosis of hyperparathyroidism: a population-based study. Am J Med 104:115-122
14. Trivedi DP, Doll R, Khaw KT 2003 Effect of four monthly oral vitamin D (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 326:469
15. Zochling J, Sitoh YY, Lau TC, Cameron ID, Cumming RG, Lord SR, Schwarz J, Trube A, March LM, Sambrook PN 2002 Quantitative ultrasound of the calcaneus and falls risk in the institutionalized elderly. Osteoporos Int 13: 882-887
16. Holtzman J, Lurie N 1996 Causes of increasing mortality in a nursing home population. J Am Geriatr Soc 44:258-264
17. Nowson CA, Sherwin AJ, McPhee JG, Wark JD, Flicker L 2003 Energy, protein, calcium and vitamin D and fibre intake from meals in residential care establishments in Australia. Asia Pac J Clin Nutr 12:172-177
18. Cockcroft DW, Gault MH 1976 Prediction of creatinine clearance from serum creatinine. Nephron 16:31-41
19. Sambrook PN, Chen C, March LM, Cameron ID, Cumming RG, Lord SR, Zochling J, Sitoh YY, Lau TC, Schwarz J, Seibel M 2004 Serum parathyroid hormone predicts time to first fall independent of vitamin D status in a frail elderly population. J Clin Endocrinol Metab 89:1572-1576
20. Owen WF, Lew NL, Liu Y, Lowrie EG, Lazarus JM 1993 The urea reduction ratio and serum albumin concentration as predictors of mortality in patients undergoing hemodialysis. N Engl J Med 329:1001-1006
21. Selberg O, Sels S 2001 The adjunctive value of routine biochemistry in nutritional assessment of hospitalised patients. Clin Nutr 20:477-485
22. Melton LJ 2002 The epidemiology of primary hyperparathyroidism in North America. J Bone Miner Res 17(Suppl 2):N12-N17
23. Adami S, Marcocci C, Gatti D 2002 Epidemiology of primary hyperparathyroidism in Europe. J Bone Miner Res 17(Suppl 2):N18-N23
24. Rostand SG, Drueke TB 1999 Parathyroid hormone, vitamin D and cardiovascular disease in chronic renal failure. Kidney Int 57:740-741
25. Block G, Port FK 2003 Calcium phosphate metabolism and cardiovascular disease in patients with chronic kidney disease. Semin Dialysis 16:140-147
26. Carlstedt F, Wind L, Wide L, Lindahl B, Hanni A, Rastad J, Ljunghall S 1997 Serum levels of parathyroid hormone are related to mortality and severity of illness in patients in the emergency department. Eur J Clin Invest 27:977-981
27. Wang R, Wu L, Karpinski E, Pang PK 1993 The changes in contractile status of single vascular smooth muscle cells and ventricular cells induced by bPTH-(1-34). Life Sci 52:793-801
28. Baczynski R, Massry SG, Kohan R, Magott M, Saglikes Y, Brautbar N 1985 Effect of parathyroid hormone on myocardial energy metabolism in the rat. Kidney Int 27:718-725
29. Smogorzewski M, Perna AF, Borum PR, Massry SG 1988 Fatty acid oxidation in the myocardium: effects of parathyroid hormone and CRF. Kidney Int 34:797-803
30. Ohara N, Hiramatsu K, Shigematsu S, Hayashi Y, Ishihara F, Aizawa T, Niwa A, Yamada T, Hashizume K 1995 Effect of parathyroid hormone on left ventricular diastolic function in patients with primary hyperparathyioidism. Miner Electrolyte Metab 21:63-66
31. London GM, De Vernejoul MC, Fabiani F, Marchais SJ, Guerin AP, Metivier F, London AM, Llach F 1987 Secondary hyperparathyroidism and cardiac hypertrophy in hemodialysis patients. Kidney Int 32:900-907
32. Veslergaard H, Ostergaard Krisfensen L 2002 Normocalcemia and persistent elevated serum concentrations of 1-84 parathyroid hormone after operation for sporadic parathyroid adenoma: evidence of increased morbidity from cardiovascular disease. World J Surg 26:657-660
33. Lips P 2001 Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 22:477-501
34. Slovik DM, Adams JS, Neer RM, Holick MF, Potts JT 1981 Deficient production of 1,25-dihydroxyvitamin D in elderly osteoporotic patients. N Engl J Med 305:372-374
35. Teng M, Wolf M, Lowrie E, Ofsthun N, Lazaru M, Thadhani R 2003 Survival of patients undergoing hemodialysis with paricalcitriol or calcitriol therapy. N Engl J Med 349:446-456
36. Bauer DC, Palermo L, Black D, Cauley JA 2002 Quantitative ultrasound and mortality: a prospective study. Osteoporos Int 13:606-612
37. Chen L, Walker S, Tong S 2002 The impact of the variation in death certification and coding practices on trends in mortality from ischaemic heart disease. Aust Health Rev 25:189-197
38. Goldberg TH, Finkelstein MS 1987 Difficulties in estimating glomerular filtration rate in the elderly. Arch Intern Med 147:1430-1433
39. Van den Noortgate NJ, Janssens WH, Delanghe JR, Afschrift MB, Lamieire NH 2002 Serum cystatin C concentration compared with other markers of glomerular filtration rate in the old old. J Am Geriatr Soc 50:1278-1282
40. Harmoinen A, Lehtimaki T, Korpela M, Turjanmaa V, Saha H 2003 Diagnostic accuracies of plasma creatinine, cystatin C, and glomerular filtration rate calculated by the Cockcroft-Gault and Levey (MDRD) formulas. Clin Chem 49:1223-1225