Transition from long-term nonprogression to HIV-1 disease associated with escape from cellular immune control

Journal of Acquired Immune Deficiency Syndromes

Volumn 48, Issue 2, 2008, Pages 119-126

  Kemal, Kimdar Sherefa ^a   Beattie, Tara ^b   Dong, Tao ^b   Weiser, Barbara ^a,c   Kaul, Rupert ^d   Kuiken, Carla ^e   Sutton, Julian ^b   Lang, Dorothy ^e   Yang, Hongbing ^b   Peng, Yan Chun ^b   Collman, Ronald ^f   Philpott, Sean ^a   Rowland Jones, Sarah ^b   Burger, Harold ^a,c  

^a WADSWORTH CENTER   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c ALBANY MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

^e LOS ALAMOS NATIONAL LABORATORY   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

HIV 1 cellular immune control; HIV 1 complete genomic RNA sequence; HIV 1 correlates of protection; HIV 1 cytotoxic T lymphocyte escape; HIV 1 long term nonprogressor

Indexed keywords

CHEMOKINE RECEPTOR CCR5; EFAVIRENZ; EMTRICITABINE; GENOMIC RNA; LEUKOCYTE ANTIGEN; TENOFOVIR; EPITOPE; GAMMA INTERFERON; HLA ANTIGEN; VIRUS RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; CASE REPORT; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; DISEASE COURSE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE RESPONSE; LYMPHOCYTE FUNCTION; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA SEQUENCE; VIREMIA; VIRUS MUTATION; AMINO ACID SEQUENCE; BIOSYNTHESIS; BLOOD; CYTOTOXIC T LYMPHOCYTE; GENETICS; IMMUNOLOGY; MOLECULAR GENETICS; VIROLOGY;

ACQUIRED IMMUNODEFICIENCY SYNDROME; AMINO ACID SEQUENCE; DISEASE PROGRESSION; EPITOPES, T-LYMPHOCYTE; HIV-1; HLA ANTIGENS; HUMANS; INTERFERON TYPE II; MALE; MOLECULAR SEQUENCE DATA; RNA, VIRAL; T-LYMPHOCYTES, CYTOTOXIC;

EID: 46449124040     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e31816b6abd     Document Type: Article

References (53)

1. Deeks SG, Walker BD. Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy. Immunity. 2007;27:406-416.
2. Cao Y, Qin L, Zhang L, et al. Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N Engl J Med. 1995;332:201-208.
3. Pantaleo G, Menzo S, Vaccarezza M, et al. Studies in subjects with long-term nonprogressive human immunodeficiency virus infection. N Engl J Med. 1995;332:209-216.
4. Blaak H, van't Wout AB, Brouwer M, et al. In vivo HIV-1 infection of CD45RA(+)CD4(+) T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4(+) T cell decline. Proc Natl Acad Sci USA. 2000;97:1269-1274.
5. Carrington M, Nelson GW, Martin MP, et al. HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage. Science. 1999; 283:1748-1752.
6. Douek DC, McFarland RD, Keiser PH, et al. Changes in thymic function with age and during the treatment of HIV infection. Nature. 1998;396: 690-695.
7. Fang G, Kuiken C, Weiser B, et al. Long-term survivors in Nairobi: complete HIV-1 RNA sequences and immunogenetic associations. J Infect Dis. 2004;190:697-701.
8. McDermott DH, Zimmerman PA, Guignard F, et al. CCR5 promoter polymorphism and HIV-1 disease progression. Multicenter AIDS Cohort Study (MACS). Lancet. 1998;352:866-870.
9. Rosenberg ES, Billingsley JM, Caliendo AM, et al. Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia. Science. 1997;278:1447-1450.
10. Sankaran S, Guadalupe M, Reay E, et al. Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1-infected nonprogressors. Proc Natl Acad Sci USA. 2005;102: 9860-9865.
11. Shankarappa R, Margolick JB, Gange SJ, et al. Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection. J Virol. 1999;73:10489-10502.
12. Troyer RM, Collins KR, Abraha A, et al. Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progression. J Virol. 2005;79:9006-9018.
13. Xiang J, Wunschmann S, Diekema DJ, et al. Effect of coinfection with GB virus C on survival among patients with HIV infection. N Engl J Med. 2001;345:707-714.
14. Deacon NJ, Tsykin A, Solomon A, et al. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science. 1995;270:988-991.
15. Fang G, Burger H, Chappey C, et al. Analysis of transition from long-term nonprogressive to progressive infection identifies sequences that may attenuate HIV type 1. AIDS Res Hum Retroviruses. 2001;17:1395-1404.
16. Lum JJ, Cohen OJ, Nie Z, et al. Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis. J Clin Invest. 2003;111:1547-1554.
17. Shioda T, Oka S, Xin X, et al. In vivo sequence variability of human immunodeficiency virus type 1 envelope gp120: association of V2 extension with slow disease progression. J Virol. 1997;71:4871-4881.
18. Masciotra S, Owen SM, Rudolph D, et al. Temporal relationship between V1V2 variation, macrophage replication, and coreceptor adaptation during HIV-1 disease progression. AIDS. 2002;16:1887-1898.
19. Wang B, Spira TJ, Owen S, et al. HIV-1 strains from a cohort of American subjects reveal the presence of a V2 region extension unique to slow progressors and non-progressors. AIDS. 2000;14:213-223.
20. Huang Y, Zhang L, Ho DD. Characterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection. J Virol. 1995;69:93-100.
21. Hendel H, Caillat-Zucman S, Lebuanec H, et al. New class I and II HLA alleles strongly associated with opposite patterns of progression to AIDS. J Immunol. 1999;162:6942-6946.
22. Huang Y, Paxton WA, Wolinsky SM, et al. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression [see comment]. Nat Med. 1996;2:1240-1243.
23. Migueles SA, Sabbaghian MS, Shupert WL, et al. HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors. Proc Natl Acad Sci USA. 2000;97: 2709-2714.
24. Smith MW, Carrington M, Winkler C, et al. CCR2 chemokine receptor and AIDS progression. Nat Med. 1997;3:1052-1053.
25. Borrow P, Lewicki H, Hahn BH, et al. Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol. 1994;68:6103-6110.
26. Koup RA, Safrit JT, Cao Y, et al. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol. 1994;68:4650-4655.
27. Barouch DH, Kunstman J, Kuroda MJ, et al. Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes. Nature. 2002;415:335-339.
28. Borrow P, Lewicki H, Wei X, et al. Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat Med. 1997;3: 205-211.
29. Evans DT, O'Connor DH, Jing P, et al. Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef. Nat Med. 1999;5:1270-1276.
30. Goulder PJ, Phillips RE, Colbert RA, et al. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nat Med. 1997;3:212-217.
31. Phillips RE, Rowland-Jones S, Nixon DF, et al. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature. 1991;354:453-459.
32. Addo MM, Yu XG, Rathod A, et al. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation toviral load. J Virol. 2003;77:2081-2092.
33. Altfeld M, Addo MM, Shankarappa R, et al. Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences. J Virol. 2003;77:7330-7340.
34. Kelleher AD, Long C, Holmes EC, et al. Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses. J Exp Med. 2001;193:375-386.
35. Tang J, Costello C, Keet IP, et al. HLA class I homozygosity accelerates disease progression in human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses. 1999;15:317-324.
36. Bunce M, O'Neill CM, Barnardo MC, et al. Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP). Tissue Antigens. 1995;46:355-367.
37. Fang G, Weiser B, Kuiken C, et al. Recombination following superinfection by HIV-1. AIDS. 2004;18:153-159.
38. Kemal K, Reinis M, Weiser B, et al. Methods for viral RNA isolation and PCR amplification for sequencing of near full-length HIV-1 genomes. In: Prasad V, Kalpana G, eds. Methods in Molecular Biology: HIV Protocols. 2nd ed. Totowa, NJ: Humana. In press.
39. Kemal KS, Foley B, Burger H, et al. HIV-1 in genital tract and plasma of women: compartmentalization of viral sequences, coreceptor usage, and glycosylation. Proc Natl Acad Sci USA. 2003;100:12972-12977.
40. Singh A, Yi Y, Isaacs SN, et al. Concordant utilization of macrophage entry coreceptors by related variants within an HIV type 1 primary isolate viral swarm. AIDS Res Hum Retroviruses. 2001;17:957-963.
41. Cardozo T, Kimura T, Philpott S, et al. Structural basis for coreceptor selectivity by the HIV-1 V3 loop. AIDS Res Hum Retroviruses. 2007;23: 415-426.
42. Beattie T, Kaul R, Rostron T, et al. Screening for HIV-specific T-cell responses using overlapping 15-mer peptide pools or optimized epitopes. AIDS. 2004;18:1595-1598.
43. Miyahira Y, Murata K, Rodriguez D, et al. Quantification of antigen specific CD8+ T cells using an ELISPOT assay. J Immunol Methods. 1995;181:45-54.
44. Frahm N, Korber BT, Adams CM, et al. Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities. J Virol. 2004;78:2187-2200.
45. Price P, Witt C, Allcock R, et al. The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopath-ological diseases. Immunol Rev. 1999;167:257-274.
46. Jones NA, Wei X, Flower DR, et al. Determinants of human immunodeficiency virus type 1 escape from the primary CD8+ cytotoxic T lymphocyte response. J Exp Med. 2004;200:1243-1256.
47. Leslie AJ, Pfafferott KJ, Chetty P, et al. HIV evolution: CTL escape mutation and reversion after transmission. Nat Med. 2004;10:282-289.
48. + lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J Clin Invest. 2001;107:1303-1310.
49. Altfeld M, Allen TM, Yu XG, et al. HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus. Nature. 2002;420:434-439.
50. Sun JC, Williams MA, Bevan MJ. CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection. Nat Immunol. 2004;5:927-933.
51. Wherry EJ, Ahmed R. Memory CD8 T-cell differentiation during viral infection. J Virol. 2004;78:5535-5545.
52. Douek DC, Brenchley JM, Betts MR, et al. HIV preferentially infects HIV-specific CD4+ T cells. Nature. 2002;417:95-98.
53. Keoshkerian E, Ashton LJ, Smith DG, et al. Effector HIV-specific cytotoxic T-lymphocyte activity in long-term nonprogressors: associations with viral replication and progression. J Med Virol. 2003;71:483-491.