Down-modulation of erbB2 activity is necessary but not enough in the differentiation of 3T3-L1 preadipocytes

Journal of Cellular Biochemistry

Volumn 104, Issue 1, 2008, Pages 274-285

  Pagano, Eleonora ^a   Coso, Omar ^b,d   Calvo, Juan Carlos ^a,c  

^a INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

^b INSTITUTO DE FISIOLOGÍA   (Argentina)

^c UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^d NONE

Author keywords

3T3 L1; Adipogenesis; EGFR erbB1; erbB2; Tyrphostin

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 5 (2 BENZOTHIAZOLYL)THIOMETHYL 4 HYDROXY 3 METHOXYBENZYLIDENECYANOACETAMIDE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; DEXAMETHASONE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HETERODIMER; ISOBUTYLMETHYLXANTHINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TYRPHOSTIN; TYRPHOSTIN AG 879; UNCLASSIFIED DRUG;

ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN 3T3; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; FUNCTIONAL PROTEOMICS; INHIBITION KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; ADIPOCYTE; ANIMAL; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; GENE EXPRESSION REGULATION; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2;

EID: 46449121073     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21621     Document Type: Article

References (40)

1. Adachi H, Kurachi H, Homma H, Adachi K, Takashi I, Morishige K, Matsuzawa Y, Miyake A. 1994. Epidermal growth factor promotes adipogenesis of 3T3-L1 cell in vitro. Endocrinology 135:1824-1830.
2. Ailhaud G. 1997. Obesity and the adipocyte. Molecular mechanisms of adipocyte differentiation. J Endocrinol 155:201-202.
3. Boney CM, Moats-Staats BM, Stiles AD, D'Ercole AJ. 1994. Expression of insulin-like growth factor-1 (IGF-1) and IGF-1 binding proteins during adipogenesis. Endocrinology 135:1863-1868.
4. Boney CM, Smith RM, Gruppuso PA. 1998. Modulation of insulin-like growth factor 1 mitogenic signaling in 3T3-L1 preadipocyte differentiation. Endocrinology 139:1638-1644.
5. Boney CM, Gruppuso PA, Faris RA, Frackelton AR Jr. 2000. The critical role of Shc in insulin-like growth factor-1-mediated mitogenesis and differentiation in 3T3-L1 preadipocytes. Mol Endocrinol 14:805-813.
6. Boney CM, Sekimoto H, Gruppuso PA, Frackelton AR Jr. 2001. Src family tyrosine kinases participate in insulin-like growth factor 1 mitogenic signaling in 3T3-L1 cells. Cell Growth Differ 12:379-386.
7. Britsch S, Li L, Kirchhoff S, Theuring F, Brinkmann V, Birchmeier C, Riethmacher D. 1998. The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev 12:1825-1836.
8. Cornelius P, MacDougald O, Lane MD. 1994. Regulation of adipocyte development. Annu Rev Nutr 14:99-129.
9. Darcy KM, Wohlhueter AL, Zangani D, Vaughan MM, Russell JA, Masso-Welch PA, Varela SM, Shoemaker S, Horn E, Lee PP, Huang RY, Ip MM. 1999. Selective changes in EGF receptor expression and function during the proliferation, differentiation and apoptosis of mammary epithelial cells. Eur J Cell Biol 78:511-523.
10. Darcy KM, Zangani D, Wohlhueter AL, Huang RY, Vaughan MM, Russell JA, Ip MM. 2000. Changes in erbB2 (her-2/neu), erbB3, and erbB4 during growth, differentiation, and apoptosis of normal rat mammary epithelial cells. J Histochem Cytochem 48:63-80.
11. Engelman J, Lisanti M, Scherer P. 1998. Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis. J Biol Chem 273:32111-32120.
12. Font de Mora J, Porras A, Ahn N, Santos E. 1997. Mitogen-activated protein kinase activation is not necessary for but antagonizes, 3T3-L1 differentiation. Mol Cell Biol 17:6068-6075.
13. Graus-Porta D, Beerli RR, Daly JM, Hynes NE. 1997. ErbB-2, the preferred heterodimerization partner of all erbB receptors, is a mediator of lateral signaling. EMBO J 16:1647-1655.
14. Green H, Kehinde O. 1974. Sublines of mouse 3T3 cells that accumulate lipid. Cell 1:113-116.
15. Hardy R, Gupta K, MacDonald J, Williford J, Wells A. 1995. Epidermal growth factor (EGF) receptor carboxy-terminal domains are required for EGF-induced glucose transport in transgenic 3T3-L1 adipocytes. Endocrinology 136:431-439.
16. Kim S, Houtman JCD, Jiang J, Ruppert M, Bertics PJ, Frank SJ. 1999. Growth hormone-induced alteration in erbB-2 phosphorylation status in 3T3-F442A fibroblasts. J Biol Chem 274:36015-36024.
17. Kokai Y, Dobashi K, Weiner D, Myers J, Nowell P, Greene MI. 1988. Phosphorylation process induced by epidermal growth factor alters the oncogenic and cellular neu (NGL) gene products. Proc Natl Acad Sci USA 85:5389-5393.
18. Kurachi H, Adachi H, Ohtsuka S, Morishige K, Amemiya K, Keno Y, Shimomura I, Tokunaga K, Miyake A, Matsuzawa Y, Tanizawa O. 1993. Involvement of epidermal growth factor in inducing obesity in ovariectomized mice. Am J Physiol 265:E323-E331.
19. Lee KF, Simon H, Chen H, Bates B, Hung MC, Hauser C. 1995. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378:394-398.
20. Lenferink A, Busse D, Flanagan W, Yakes F, Arteaga C. 2001. ErbB2/neu kinase modulates cellular p27(kip1) and cyclin D1 through multiple signaling pathways. Cancer Res 61:6583-6591.
21. Levitzki A, Gazit A. 1995. Tyrosine kinase inhibition: An approach to drug development. Science 267:1782-1788.
22. Lowell BB. 1999. PPARg: An essential regulator of adipogenesis andmodulator of fat cell function. Cell 99:239-242.
23. Mandrup S, Lane MD. 1997. Regulating adipogenesis. J Biol Chem 272:5367-5370.
24. Menendez J, Vellon L, Mehmi I, Oza B, Ropero S, Colomer R, Lupu R. 2004. Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proc Natl Acad Sci USA 101:10715-10720.
25. Morrison RF, Farmer SR. 2000. Symposium: Adipocyte function, differentiation and metabolism. Hormonal signaling and transcriptional control of adipocyte differentiation. J Nutr 130(12):3116S-3121S.
26. Must A, Spadano E, Coakley A, Field A, Colditz G, Dietz W. 1999. The disease burden associated with overweight and obesity. J Am Med Assoc 282:1523-1529.
27. Nguyen T, Scimeca J, Filloux C, Peraldi P, Carpentier J, Van Obberghen E. 1993. Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal growth factor. J Biol Chem 268:9803-9810.
28. Olayioye MA. 2002. Update on HER-2 as a target for cancer therapy. Intracellular signaling pathways of ErbB2/HER-2 and family members. Breast Cancer Res 3:385-389.
29. Olayioye MA, Graus-Porta D, Beerli RR, Rohrer J, Gay B, Hynes NE. 1998. ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner. Mol Cell Biol 18:5042-5051.
30. Olayioye MA, Neve R, Lane HA, Hynes NE. 2000. The ErbB signaling network: Receptor heterodimerization in development and cancer. EMBO J 19:3159-3167.
31. Pagano E, Calvo JC. 2003. ErbB2 and EGFR are down-modulated during the differentiation of 3T3-L1 preadipocytes. J Cell Biochem 90:561-572.
32. Prusty D, Park B-H, Davis KE, Farmer SR. 2002. Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor γ (PPARγ) and C/EBPα gene espression during the differentiation of 3T3-L1 preadipocytes. J Biol Chem 277:46226-46232.
33. neu and epidermal growth factor receptor associate into a strucutre composed of activated kinases. Proc Natl Acad Sci USA 89:1330-1334.
34. Reed BC, Kaufmann SH, Mackall JC, Student AK, Lane MD. 1977. Alterations in insulin binding accompaying differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci USA 74:4876-4880.
35. Schmidt W, Pöll-Jordan G, Löffler G. 1990. Adipose convertion of 3T3-L1 cells in a serum-free culture system depends on epidermal growth factor, insulin-like growth factor-1, corticosterone, and cyclic AMP. J Biol Chem 265:15489-15495.
36. Schroeder JA, Lee DC. 1998. Dynamic expression and activation of ERBB receptors in the developing mouse mammary gland. Cell Growth Differ 9:451-464.
37. Serrero G. 1987. EGF inhibits the differentiation of adipocyte precursors in primary cultures. Biochem Biophys Res Commun 146:194-202.
38. Serrero G, Mills D. 1991. Physiologic role of EGF on adipose tissue development in vivo. Proc Natl Acad Sci USA 88:3912-3916.
39. Smith PJ, Wise LS, Berkowitz R, Wan C, Rubin CS. 1988. Insulin-like growth factor-1 is an essential regulator of the differentiation of 3T3-L1 adipocytes. J Biol Chem 263:9402-9408.
40. neu protein and EGF receptor modulates EGF receptor function. Cell 61:1339-1347.