Effect of xanthohumol on melanogenesis in B16 melanoma cells

Experimental and Molecular Medicine

Volumn 40, Issue 3, 2008, Pages 313-319

  Koo, Jeung Hyun ^a   Hyoung, Tae Kim ^a   Yoon, Ha Yong ^a   Kwon, Kang Beom ^b   Choi, Ii Whan ^c   Sung, Hoo Jung ^a   Kim, Han Uk ^a   Park, Byung Hyun ^a   Park, Jin Woo ^a  

^a Chonbuk National University   (South Korea)

^b Wonkwang University   (South Korea)

^c Inje University   (South Korea)

Author keywords

Cell differentiation; Melanins; Melanocytes; Microphthalmia associated transcription factor; Monophenol monooxygenase; Xanthohumol

Indexed keywords

ALPHA INTERMEDIN; COMPLEMENTARY DNA; CYCLIC AMP; FORSKOLIN; ISOBUTYLMETHYLXANTHINE; MELANIN; MESSENGER RNA; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MONOPHENOL MONOOXYGENASE; XANTHOHUMOL;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DOWN REGULATION; ENZYME ACTIVITY; HUMULUS LUPULUS; HYPOPIGMENTATION; MELANOGENESIS; MELANOMA CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

HUMULUS LUPULUS;

EID: 46449104880     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2008.40.3.313     Document Type: Article

References (43)

1. Beavo JA, Rogers NL, Crofford OB, Hardman JG, Sutherland EW, Newman EV. Effects of xanthine derivatives on lipolysis and on adenosine 3′,5′-monophosphate phosphodiesterase activity. Mol Pharmacol 1970;6:597-603
2. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54
3. Busca R, Ballotti R. Cyclic AMP a key messenger in the regulation of skin pigmentation. Pigment Cell Res 2000;13:60-9
4. Cone RD, Lu D, Koppula S, Vage DI, Klungland H, Boston B, Chen W, Orth DN, Pouton C, Kesterson RA. The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Prog Horm Res 1996;51:287-317
5. Costin GE, Hearing VJ. Human skin pigmentation: melanocytes modulate skin color in response to stress. Faseb J 2007;21:976-94
6. Eller MS, Gilchrest BA. Tanning as part of the eukaryotic SOS response. Pigment Cell Res 2000;13(Suppl 8):94-7
7. Frolich S, Schubert C, Bienzle U, Jenett-Siems K. In vitro antiplasmodial activity of prenylated chalcone derivatives of hops (Humulus lupulus) and their interaction with haemin. J Antimicrob Chemother 2005;55:883-7
8. Gerhauser C, Alt A, Heiss E, Gamal-Eldeen A, Klimo K, Knauft J, Neumann I, Scherf HR, Frank N, Bartsch H, Becker H. Cancer chemopreventive activity of xanthohumol, a natural product derived from hop. Mol Cancer Ther 2002;1:959-69
9. Hearing VJ, Jimenez M. Mammalian tyrosinase - the critical regulatory control point in melanocyte pigmentation. Int J Biochem 1987;19:1141-7
10. Hearing VJ. Regulation of melanin formation. In The Pigmentary System: Physiology and Pathophysiology (Nordlund JJ, Boissy RE, Hearing VJ, King RA, Ortonne JP, eds), 1998,423-38, Oxford University Press, Inc., New York, NY
11. Hearing VJ. Biochemical control of melanogenesis and melanosomal organization. J Investig Dermatol Symp Proc 1999;4:24-8
12. Hussong R, Frank N, Knauft J, Ittrich C, Owen R, Becker H, Gerhauser C. A safety study of oral xanthohumol administration and its influence on fertility in Sprague Dawley rats. Mol Nutr Food Res 2005;49:861-7
13. Jung GD, Yang JY, Song ES, Park JW. Stimulation of melanogenesis by glycyrrhizin in B16 melanoma cells. Exp Mol Med 2001;33:131-5.
14. Kim DS, Park SH, Kwon SB, Park ES, Huh CH, Youn SW, Park KC. Sphingosylphosphorylcholine-induced ERK activation inhibits melanin synthesis in human melanocytes. Pigment Cell Res 2006;19:146-53
15. Kobayashi T, Urabe K, Winder A, Jimenez-Cervantes C, Imokawa G, Brewington T, Solano F, Garcia-Borron JC, Hearing VJ. Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis. Embo J 1994;13:5818-25
16. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-5
17. Lerch K. Monophenol monooxygenase from Neurospora crassa. Methods Enzymol 1987;142:165-9
18. Levy C, Khaled M, Fisher DE. MITF: master regulator of melanocyte development and melanoma oncogene. Trends Mol Med 2006;12:406-14
19. Lin JY, Fisher DE. Melanocyte biology and skin pigmentation. Nature 2007;445:843-50
20. Lv N, Koo JH, Yoon HY, Yu J, Kim KA, Choi IW, Kwon KB, Kwon KS, Kim HU, Park JW, Park BH. Effect of Angelica gigas extract on melanogenesis in B16 melanoma cells. Int J Mol Med 2007;20:763-7
21. Miranda CL, Stevens JF, Ivanov V, McCall M, Frei B, Deinzer ML, Buhler DR. Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro. J Agric Food Chem 2000;48:3876-84
22. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63
23. Pan L, Becker H, Gerhauser C. Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway. Mol Nutr Food Res 2005;49:837-43
24. Park HY, Russakovsky V, Ohno S, Gilchrest BA. The β isoform of protein kinase C stimulates human melanogenesis by activating tyrosinase in pigment cells. J Biol Chem 1993;268:11742-9
25. Parvez S, Kang M, Chung HS, Cho C, Hong MC, Shin MK, Bae H. Survey and mechanism of skin depigmenting and lightening agents. Phytother Res 2006;20:921-34
26. Pawelek JM, Chakraborty AK. The enzymology of melanogenesis. In The Pigmentary System: Physiology and Patho-Physiology (Nordlund JJ, Boissy RE, Hearing VJ, King RA, Ortonne J-P, eds), 1998, 391-400, Oxford University Press, Inc., New York, NY
27. Plazar J, Zegura B, Lah TT, Filipic M. Protective effects of xanthohumol against the genotoxicity of benzo(a)pyrene (BaP), 2-amino-3-methylimidazo[4,5-f] quinoline (IQ) and tert-butyl hydroperoxide (t-BOOH) in HepG2 human hepatoma cells. Mutat Res 2007;632:1-8
28. Sasaki M, Horikoshi T, Uchiwa H, Miyachi Y. Up-regulation of tyrosinase gene by nitric oxide in human melanocytes. Pigment Cell Res 2000;13:248-52
29. Schallreuter KU, Kothari S, Hasse S, Kauser S, Lindsey NJ, Gibbons NC, Hibberts N, Wood JM. In situ and in vitro evidence for DCoH/HNF-1α transcription of tyrosinase in human skin melanocytes. Biochem Biophys Res Commun 2003;301:610-6
30. Schallreuter KU. Advances in melanocyte basic science research. Dermatol Clin 2007;25:283-91
31. Solano F, Briganti S, Picardo M, Ghanem G. Hypopigmenting agents: an updated review on biological, chemical and clinical aspects. Pigment Cell Res 2006;19:550-71
32. Stevens JF, Page JE. Xanthohumol and related prenylflavonoids from hops and beer: to your good health! Phytochemistry 2004;65:1317-30
33. Tachibana M. MITF: a stream flowing for pigment cells. Pigment Cell Res 2000;13:230-40
34. 2+ by forskolin and phorbol ester. FEBS Lett 1985;183:430-2
35. Tobe H, Muraki Y, Kitamura K, Komiyama O, Sato Y, Sugioka T, Maruyama HB, Matsuda E, Nagai M. Bone resorption inhibitors from hop extract. Biosci Biotechnol Biochem 1997;61:158-9
36. Vanhoecke BW, Delporte F, Van Braeckel E, Heyerick A, Depypere HT, Nuytinck M, De Keukeleire D, Bracke ME. A safety study of oral tangeretin and xanthohumol administration to laboratory mice. In Vivo 2005;19:103-7
37. Wakamatsu K, Graham A, Cook D, Thody AJ. Characterisation of ACTH peptides in human skin and their activation of the melanocortin-1 receptor. Pigment Cell Res 1997;10:288-97
38. Wang Q, Ding ZH, Liu JK, Zheng YT. Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus. Antiviral Res 2004;64:189-94
39. Xu W, Gong L, Haddad MM, Bischof O, Campisi J, Yeh ET, Medrano EE. Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9. Exp Cell Res 2000;255:135-43
40. Yamaguchi Y, Brenner M, Hearing VJ. The regulation of skin pigmentation. J Biol Chem 2007;282:27557-61
41. Yang JY, Koo JH, Song YG, Kwon KB, Lee JH, Sohn HS, Park BH, Jhee EC, Park JW. Stimulation of melanogenesis by scoparone in B16 melanoma cells. Acta Pharmacol Sin 2006;27:1467-73
42. Yang JY, Della-Fera MA, Rayalam S, Baile CA. Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis. Apoptosis 2007;12:1953-63
43. Yokoyama K, Yasumoto K, Suzuki H, Shibahara S. Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression. J Biol Chem 1994;269:27080-7