Peripheral B-cell CD5 expansion and CD81 overexpression and their association with disease severity and autoimmune markers in chronic hepatitis C virus infection

Clinical and Experimental Immunology

Volumn 128, Issue 2, 2002, Pages 353-358

  Zuckerman, E ^a   Slobodin, G ^a   Kessel, A ^a   Sabo, E ^b   Yeshurun, D ^a   Halas, K ^a   Toubi, E ^a  

^a BNAI ZION MEDICAL CENTER   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Autoimmunity; HCV; Peripheral blood B cells

Indexed keywords

CD5 ANTIGEN; CD81 ANTIGEN; CRYOGLOBULIN; RHEUMATOID FACTOR;

ADULT; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE SEVERITY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENE OVEREXPRESSION; HEPATITIS C; HEPATITIS C VIRUS; HISTOLOGY; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MALE; PRIORITY JOURNAL; VIRUS LOAD;

ADULT; ANTIGENS, CD; ANTIGENS, CD5; AUTOIMMUNITY; B-LYMPHOCYTES; BIOLOGICAL MARKERS; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PROGNOSIS;

EID: 0036094376     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2002.01844.x     Document Type: Article

References (42)

1. Introduction. The National Institutes of Health Consensus Development Conference. Manage Hepatitis C
2. Infection of peripheral mononuclear blood cells by hepatitis C virus
3. Hepatitis C infection in patients with essential mixed cryoglobulinemia
4. A role for hepatitis C virus infection in type II cryoglobulinemia
5. Cryoglobulinemia with vasculitis associated with hepatitis C virus infection
6. Lymphocytic sialadenitis of Sjögren's syndrome associated with chronic hepatitis C virus liver disease
7. Extrahepatic manifestations in chronic hepatitis C and hepatitis C virus serotypes
8. Hepatitis C: A multifaceted disease
9. The spectrum of extrahepatic manifestations in hepatitis C virus infection
10. High prevalence of serological markers of autoimmunity in patients with chronic hepatitis C
11. Anticardiolipin antibodies in chronic hepatitis C: Implication of hepatitis C virus as the cause of the antiphospholipid syndrome
12. Hepatitis C virus infection in patients with non-Hodgkin's lymphoma
13. Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders
14. Hepatitis C infection in patients with non-Hodgkin B-cell lymphoma
15. Detection of hepatitis C virus RNA in CD19 peripheral mononuclear cells of chronically infected patients
16. L kv325 immunoglobulin gene combination in hepatitis C virus associated immunocytomas
17. The rheumatoid factor response in the etiology of mixed cryoglobulinemia associated with hepatitis C virus infection
18. Clonal B-cell expansion in peripheral blood of HCV-infected patients
19. Bone marrow findings further support the hypothesis that essential mixed cryoglobulinemia type II is characterized by monoclonal B-cell proliferation
20. Binding of hepatitis C virus to CD81
21. CD81 (TAPA-1): A molecule involved in signal transduction and cell adhesion in the immune system
22. Expansion of peripheral blood CD5+ B cells is associated with mild disease in chronic hepatitis C virus infection
23. + B cells
24. Required early complement activation in contact sensitivity with generation of local C5-dependent chemotactic activity, and late T cell interferon gamma: A possible initiating role of B cells
25. A rheumatoid arthritis B cell subset express a phenotype similar to that in chronic lymphocytic leukemia
26. B cells expressing CD5 are increased in Sjögren's syndrome
27. + B cells in patients with infectious mononucleosis
28. + B lymphocytes in HIV infection. Relationship to immunological progression of disease
29. Relationship between rheumatoid factor and the immune response against hepatitis C virus in essential mixed cryoglobulinemia
30. Hepatic lymphoid aggregates in chronic hepatitis C and mixed cryoglobulinemia
31. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
32. + B cell
33. Viruses and cryoglobulinemia
34. The rheumatoid factor response in the etiology of mixed cryoglobulins associatrd with hepatitis C virus infection
35. Interferon alfa down-regulates CD81 in patients with chronic hepatitis C
36. Assessment of hepatitis C virus RNA levels by quantitative competitive RNA polymerase chain reaction: High-titer viremia correlates with advanced stage of disease
37. Clonal analysis of intrahepatic B cells from HCV-infected patients with and without mixed cryoglobulinemia
38. Hepatitis C virus (HCV) in lymphocyte subset and in B lymphocytes expressing rheumatoid factor cross-reacting idiotype in type II mixed cryoglobulinemia
39. Serological and clinical markers of autoimmune disease in HCV-infected subjects with different disease conditions
40. Hepatitis C virus (HCV) infection and cryoglobulinemia: Analysis of whole blood and plasma HCV-RNA concentrations and correlation with liver histology
41. Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10
42. The role of CD5-expressing B cells in health and disease