Overexpression of Drosophila Rad51 protein (DmRad51) disrupts cell cycle progression and leads to apoptosis

Chromosoma

Volumn 113, Issue 2, 2004, Pages 92-101

  Yoo, Siuk ^a   McKee, Bruce D ^b  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; DROSOPHILA PROTEIN; HEAT SHOCK PROTEIN; HISTONE ANTIBODY; PROTEIN P35; RAD51 PROTEIN; TRANSCRIPTION FACTOR GAL4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE; CELL DEATH; CELL DISRUPTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DROSOPHILA; EYE; FLY; FORELIMB; GENE EXPRESSION SYSTEM; GENE INDUCTION; GENE OVEREXPRESSION; HEAT SHOCK; HETEROZYGOTE; IMAGINAL DISC; IMMUNOCYTOCHEMISTRY; LETHAL GENE; NICK END LABELING; NONHUMAN; PHENOTYPE; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; REGULATORY MECHANISM; STAINING; TISSUE SPECIFICITY; TRANSGENE;

ANIMALS; APOPTOSIS; CELL CYCLE; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; PROMOTER REGIONS (GENETICS); RAD51 RECOMBINASE; TRANSFECTION;

EID: 4644336715     PISSN: 00095915     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00412-004-0300-x     Document Type: Article

References (47)

1. Aihara H, Kurumizaka Y, Ito H, Yokoyama S, Shibata T (1999) The N-terminal domain of the human Rad51 protein binds DNA: structure and a DNA binding surface as revealed by NMR. J Mol Biol 290:495-504
2. Akaboshi E, Inoue Y, Ryo H (1994) Cloning of the cDNA and genomic DNA that correspond to the recA-like gene of Drosophila melanogaster. Jpn J Genet 69:663-670
3. Basile G, Aker M, Mortimer RK (1992) Nucleotide sequence and transcriptional regulation of the yeast recombinational repair gene RAD51. Mol Cell Biol 12:3235-3246
4. Baumann P, West SC (1998) Role of the human Rad51 protein in homologous recombination and double-stranded-break repair. Trends Biol Sci 23:247-251
5. Buchhop S, Gibson MK, Wang XW, Wagner P, Sturzbecher H-W, Harris C (1997) Interaction of p53 with the human Rad51 protein. Nucleic Acids Res 25:3868-3874
6. Chen P-L, Chen C-F, Chen Y, Xioa J, Sharp D, Lee W-H (1998) The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. Proc Natl Acad Sci USA 95:5287-5292
7. Chen G, Yuan S-SF, Liu W, Xu Y, Trujillo K, Song B, Cong F, Goff SP, Wu Y, Arlinghaus R, Baltimore D, Gassers PJ, Park MS, Sung P, Lee EY-HP (1999) Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl. J Biol Chem 274:12748-12752
8. Clem RJ, Fechheimer M, Miller LK (1991) Prevention of apoptosis by a Baculovirus gene during infection of insect cells. Science 254:1388-1390
9. Doren MV, Williamson AL, Lehmann R (1998) Regulation of zygotic gene expression in Drosophila primordial germ cells. Curr Biol 8:243-246
10. Edelmann W, Kucherlapati R (1996) Role of recombination enzymes in mammalian cell survival. Proc Natl Acad Sci USA 93:6225-6227
11. Flygare J, Fält S, Ottervald J, Castro J, Dackland Å-L, Hellgren D, Wennborg A (2001) Effects of HsRad51 overexpression on cell proliferation, cell cycle progression, and apoptosis. Exp Cell Res 268:61-69
12. Freeman M (1996) Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87:651-660
13. Goyal L, McCall K, Agapite J, Hartwieg E, Steller H (2000) Induction of apoptosis by Drosophila reaper, hid, and grim through inhibition of IAP function. EMBO J 19:589-597
14. Gustafson K, Boulianne GL (1996) Distinct expression patterns detected within individual tissues by the GAL4 enhancer trap technique. Genome 39:174-182
15. Harlow E, Lane D (1988) Antibodies: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor
16. 1 delay and hypersensitivity to ultraviolet irradiation. Cancer Res 58:4733-4739
17. Havre PA, Rice MC, Ramos R, Kmiec EB (2000) HsRec2/Rad51L1, a protein influencing cell cycle progression, has protein kinase activity. Exp Cell Res 254:33-44
18. Hay BA, Tanya W, Rubin GM (1994) Expression of baculovirus p35 prevents cell death in Drosophila. Development 120:2121-2129
19. Helms W, Lee H, Ammerman M, Parks AL, Muskavitch MAT, Yedvobnick B (1999) Engineered truncations in the Drosophila mastermind protein disrupt notch pathway function. Dev Biol 215:358-374
20. Kim PM, Allen C, Wagener BM, Shen Z, Nickoloff JA (2001) Overexpression of human RAD51 and RAD52 reduces double-strand break-induced homologous recombination in mammalian cells. Nucleic Acids Res 29:4352-4360
21. Kondo T, Yokokura T, Nagata S (1997) Activation of distinct caspase-like proteases by Fas and reaper in Drosophila cells. Proc Natl Acad Sci USA 94:11951-11956
22. Krejci L, Damborsky J, Thomsen B, Duno M, Bendixen C (2001) Molecular dissection of interactions between Rad51 and members of the recombination-repair group. Mol Cell Biol 21:966-976
23. Kuerbitz SJ, Plunkett BS, Walsh WV, Kastan MB (1992) Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA 89:7491-7495
24. Laemmli UK (1970) Cleavage of structural proteins during assembly of the head bacteriophage T4. Nature 227:680-685
25. Lim D-S, Hasty P (1996) A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol Cell Biol 16:7133-7143
26. Lundin C, Schultz N, Amaudeau C, Mohindra A, Hansen TL, Heleday T (2003) RAD51 is involved in repair of damage associated with DNA replication in mammalian cells. J Mol Biol 328:521-535
27. Maacke H, Opitz S, Jost K, Hamdorf W, Henning W, Krüger S, Feller AC, Lopens A, Diedrich K, Schwinger E, Stürzbecher H-W (2000) Over-expression of wild-type Rad51 correlates with histological grading of invasive ductal breast cancer. Int J Cancer 88:907-913
28. McKee BD, Ren X-J, Hong C-s (1996) A recA-like gene in Drosophila melanogaster that is expressed at high levels in female but not male meiotic tissues. Chromosoma 104:479-488
29. Moses K, Rubin GM (1991) glass encodes a site-specific DNA-binding protein that is regulated in response to positional signals in the developing Drosophila eye. Genes Dev 5:583-593
30. Nooij JC de, Hariharan IK (1995) Uncoupling cell fate determination from patterned cell division in the Drosophila eye. Science 270:983-985
31. Ogawa T, Shinihara A, Nabetani A, Ikeya T, Yu X, Egelmam EH, Ogawa H (1993) RecA-like recombination proteins in eukaryotes: functions and structures of Rad51 genes. Cold Spring Harb Symp Quant Biol 58:567-576
32. Ollmann M, Young LM, Di Como CJ, Karim F, Belvin M, Robertsons S, Whittaker K, Demsky M, Fisher WW, Buchman A, Duyk G, Friedman L, Prives C, Kopczynski C (2000) Drosophila p53 is a structural and functional homolog of the tumor suppressor p53. Cell 101:91-101
33. Pronk GJ, Ramer K, Amiri P, Williams LT (1996) Requirement of an ICE-like protease for induction of apoptosis and ceramide generation by reaper. Science 271:808-810
34. Raderschall E, Bazarov A, Cao J, Lurz R, Smith A, Mann W, Ropers H-H, Sedivy JM, Golub EI, Fritz E, Haaf T (2002) Formation of higher-order nuclear Rad51 structure is functionally linked to p21 expression and protection from DNA damage-induced apoptosis. J Cell Sci 115:153-164
35. Rodriguez A, Chen P, Abrams JM (1998) Insights from model systems molecular prophets of death in the fly. Am J Hum Genet 62:514-519
36. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor
37. Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feuteun J, Ashley T, Livingston DM (1997) Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88:265-275
38. Shin DS, Pellegrin L, Daniels DS, Yelent B, Craig L, Bates D, Yu DS, Shivji MK, Hitomi C, Arvai, AS, Volkmann N, Tsuruta H, Blundell TL, Venkitaraman AR, Tainer JA (2003) Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2. EMBO J 22:4566-4576
39. Shinohara A, Ogawa H, Ogawa T (1992) Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein. Cell 69:457-470
40. Sonoda E, Buerstedde MJ-M, Bezzubova O, Shinohara A, Ogawa H, Takata M, Yamaguchi-Iwai Y, Takeda S (1998) Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death. EMBO J 17:598-608
41. Staeva-Vieira E, Yoo S, Lehmann R (2003) An essential role of DmRad51/SpnA in DNA repair and meiotic checkpoint control. EMBO J 22:5863-5874
42. Tsuzuki T, Fujii Y, Sakumi K, Tominaga Y, Nakao K, Sekiguchi M, Matsushiro A, Yoshimura Y, Morita T (1996) Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. Proc Natl Acad Sci USA 93:6236-6240
43. Vispé S, Cazaux C, Lesca C, Defais M (1998) Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation. Nucleic Acids Res 26:2859-2864
44. White K, Grether ME, Abrams JM, Young L, Farrell K, Steller H (1994) Genetic control of programmed cell death in Drosophila. Science 264:677-683
45. White K, Tahaoglu E, Steller H (1996) Cell killing by the Drosophila gene reaper. Science 271:805-807
46. Yamamoto A, Taki T, Yagi H, Habu T, Yoshida K, Yoshimura Y, Matsushiro A, Nishimune Y, Morita T (1996) Cell cycle-dependent expression of the mouse Rad51 gene in proliferating cells. Mol Genet Genomics 251:1-12
47. Yáñez RJ, Porter ACG (1999) Gene targeting is enhanced in human cells overexpressing hRAD51. Gene Ther 6:1282-1290