Dendritic cells exposed to estrogen in vitro exhibit therapeutic effects in ongoing experimental allergic encephalomyelitis

Journal of Neuroimmunology

Volumn 156, Issue 1-2, 2004, Pages 58-65

  Pettersson, Asa ^a   Ciumas, Carolina ^a   Chirsky, Vadim ^b   Link, Hans ^a   Huang, Yu Min ^a   Xiao, Bao Guo ^a,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Military Medical Academy   (Russian Federation)

^c FUDAN UNIVERSITY   (China)

Author keywords

Dendritic cells; Estrogen; Experimental allergic encephalomyelitis; Indoleamine 2,3 dioxygenase

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; CD68 ANTIGEN; ENCEPHALITOGENIC PROTEIN; ESTRADIOL; FREUND ADJUVANT; GAMMA INTERFERON; INTERLEUKIN 10; MYELIN BASIC PROTEIN; OXYGENASE; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CELL ISOLATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; LYMPHOCYTE PROLIFERATION; MACROPHAGE MIGRATION; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; T LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELLS, CULTURED; DENDRITIC CELLS; DRUG DELIVERY SYSTEMS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ESTRADIOL; FEMALE; GUINEA PIGS; INJECTIONS, SUBCUTANEOUS; RATS; RATS, INBRED LEW;

EID: 4644312907     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2004.07.004     Document Type: Article

References (39)

1. N. Amino, H. Tada, and Y. Hidaka Postpartum autoimmune thyroid syndrome: a model of aggravation of autoimmune disease Thyroid 9 1999 705 713
2. B.F. Bebo Jr., A. Fyfe-Johnson, K. Adlard, A.G. Beam, A.A. Vandenbark, and H. Offner Low-dose estrogen therapy ameliorates experimental autoimmune encephalomyelitis in two different inbred mouse strains J. Immunol. 166 2001 2080 2089
3. M. Brenan, and M. Puklavec The MRC OX-62 antigen: a useful marker in the purification of rat veiled cells with the biochemical properties of an integrin J. Exp. Med. 175 1992 1457 1465
4. R.R. Buggage, D.M. Matteson, F. Shen de, B. Sun, N. Tuaillon, and C.C. Chan Effect of sex hormones on experimental autoimmune uveoretinitis (EAU) Immunol. Invest. 32 2003 259 273
5. C.C. Chang, R. Ciubotariu, J.S. Manavalan, J. Yuan, A.I. Colovai, F. Piazza, S. Lederman, M. Colonna, R. Cortesini, R. Dalla-Favera, and N. Suciu-Foca Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4 Nat. Immunol. 3 2002 237 243
6. C.Q. Chu, S. Wittmer, and D.K. Dalton Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis J. Exp. Med. 192 2000 123 128
7. C. Confavreux, M. Hutchinson, M.M. Hours, P. Cortinovis-Tourniaire, and T. Moreau Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in Multiple Sclerosis Group [comment] N. Engl. J. Med. 339 1998 285 291
8. M. Crowley, K. Inaba, M. Witmer-Pack, and R.M. Steinman The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus Cell. Immunol. 118 1989 108 125
9. U. Eriksson, M.O. Kurrer, R. Bingisser, H.P. Eugster, P. Saremaslani, F. Follath, S. Marsch, and U. Widmer Lethal autoimmune myocarditis in interferon-gamma receptor-deficient mice: enhanced disease severity by impaired inducible nitric oxide synthase induction Circulation 103 2001 18 21
10. R. Furlan, E. Brambilla, F. Ruffini, P.L. Poliani, A. Bergami, P.C. Marconi, D.M. Franciotta, G. Penna, G. Comi, L. Adorini, and G. Martino Intrathecal delivery of IFN-γ protects C57BL/6 mice from chronic-progressive experimental autoimmune encephalomyelitis by increasing apoptosis of central nervous system-infiltrating lymphocytes J. Immunol. 167 2001 1821 1829
11. S. Gregori, M. Casorati, S. Amuchastegui, S. Smiroldo, A.M. Davalli, and L. Adorini Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance J. Immunol. 167 2001 1945 1953
12. U. Grohmann, F. Fallarino, and P. Puccetti Tolerance, DCs and tryptophan: much ado about IDO Trends Immunol. 24 2003 242 248
13. H. Honjo, K. Iwasa, S. Fushiki, T. Hosoda, H. Tatsumi, M. Mihara, Y. Hirasugi, M. Oida, K. Kariya, N. Kikuchi, and M. Kawata Estrogen and non-feminizing estrogen for Alzheimer's disease Endocr. J. 50 2003 361 367
14. T. Hosoda, N. Mito, H. Yoshino, and K. Sato Estrogen. Altered oral tolerance induction in type II collagen-induced arthritis Int. Arch. Allergy Immunol. 133 2004 19 28
15. H. Jonuleit, E. Schmitt, G. Schuler, J. Knop, and A.H. Enk Induction of IL-10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells J. Exp. Med. 192 2000 1213 1222
16. J. Komi, and O. Lassila Nonsteroidal anti-estrogens inhibit the functional differentiation of human monocyte-derived dendritic cells Blood 95 2000 2875 2882
17. S. Konnai, T. Usui, K. Ohashi, and M. Onuma The rapid quantitative analysis of bovine cytokine genes by real-time RT-PCR Vet. Microbiol. 94 2003 283 294
18. K.A. Latham, A. Zamora, H. Drought, S. Subramanian, A. Matejuk, H. Offner, and E.F. Rosloniec Estradiol treatment redirects the isotype of the autoantibody response and prevents development of autoimmune arthritis J. Immunol. 171 2003 5820 5827
19. M.K. Levings, R. Sangregorio, F. Galbiati, S. Squadrone, R. de Waal Malefyt, and M.G. Roncarolo IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells J. Immunol. 166 2001 5530 5539
20. H.Y. Liu, A.C. Buenafe, and A. Matejuk Estrogen inhibition of EAE involves effects on dendritic cell function J. Neurosci. Res. 70 2002 238 248
21. A.R. Lorenzi, and H.L. Ford Multiple sclerosis and pregnancy Postgrad. Med. J. 78 2002 460 464
22. J.S. Manavalan, P.C. Rossi, G. Vlad, F. Piazza, A. Yarilina, R. Cortesini, D. Mancini, and N. Suciu-Foca High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells Transpl. Immunol. 11 2003 245 258
23. A.L. Mellor, and D.H. Munn Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation? Immunol. Today 20 1999 469 473
24. A.L. Mellor, B. Baban, P. Chandler, B. Marshall, K. Jhaver, A. Hansen, P.A. Koni, M. Iwashima, and D.H. Munn Induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion J. Immunol. 171 2003 1652 1655
25. D.H. Munn, E. Shafizadeh, J.T. Attwood, I. Bondarev, A. Pashine, and A.L. Mellor Inhibition of T cell proliferation by macrophage tryptophan catabolism Science 1999 1191 1193
26. N.J. Olsen, and W.J. Kovacs Hormones, pregnancy, and rheumatoid arthritis J. Gend.-Specif. Med. 5 2002 28 37
27. V. Paharkova-Vatchkova, R. Maldonado, and S. Kovats Estrogen preferentially promotes the differentiation of CD11c+CD11b(intermediate) dendritic cells from bone marrow precursors J. Immunol. 172 2004 1426 1436
28. M. Polanczyk, A. Zamora, S. Subramanian, A. Matejuk, D.L. Hess, E.P. Blankenhorn, C. Teuscher, A.A. Vandenbark, and H. Offner The protective effect of 17beta-estradiol on experimental autoimmune encephalomyelitis is mediated through estrogen receptor-alpha Am. J. Pathol. 163 2003 1599 1605
29. P.K. Rabiah, and A.T. Vitale Non-infectious uveitis and pregnancy Am. J. Ophthalmol. 136 2003 91 98
30. M.L. Salem, G. Matsuzaki, K. Kishihara, G.A. Madkour, and K. Nomoto beta-estradiol suppresses T cell-mediated DTH through suppression of antigen-presenting cell function and Th1 induction Int. Arch. Allergy Immunol. 121 2000 161 169
31. A. Sapino, P. Cassoni, E. Ferrero, M. Bongiovanni, L. Righi, N. Fortunati, P. Crafa, R. Chiarle, and G. Bussolati Estrogen receptor alpha is a novel marker expressed by follicular dendritic cells in lymph nodes and tumor-associated lymphoid infiltrates Am. J. Pathol. 163 2003 1313 1320
32. N.L. Sicotte, S.M. Liva, R. Klutch, P. Pfeiffer, S. Bouvier, S. Odesa, T.C. Wu, and R.R. Voskuhl Treatment of multiple sclerosis with the pregnancy hormone estriol Ann. Neurol. 52 2002 421 428
33. D. Stober, R. Schirmbeck, and J. Reimann IL-12/IL-18-dependent IFN-gamma release by murine dendritic cells J. Immunol. 167 2001 957 965
34. S. Subramanian, A. Matejuk, A. Zamora, A.A. Vandenbark, and H. Offner Oral feeding with ethinyl estradiol suppresses and treats experimental autoimmune encephalomyelitis in SJL mice and inhibits the recruitment of inflammatory cells into the central nervous system J. Immunol. 170 2003 1548 1555
35. P. Terness, T.M. Bauer, and L. Rose Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites J. Exp. Med. 196 2002 447 457
36. K. Vermeire, L. Thielemans, P. Matthys, and A. Billiau The effects of NO synthase inhibitors on murine collagen-induced arthritis do not support a role of NO in the protective effect of IFN-gamma J. Leukoc. Biol. 68 2000 119 124
37. I. Wickelgren Estrogen research. Brain researchers try to salvage estrogen treatments Science 302 2003 1138 1139
38. D.O. Willenborg, S.A. Fordham, M.A. Staykova, I.A. Ramshaw, and W.B. Cowden IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide J. Immunol. 163 1999 5278 5286
39. Y.C. Zang, J.B. Halder, J. Hong, V.M. Rivera, and J.Z. Zhang Regulatory effects of estriol on T cell migration and cytokine profile: inhibition of transcription factor NF-kappa B J. Neuroimmunol. 124 2002 106 114