A new approach for prolonging the half-life of peptides, proteins and low-molecular-weight drugs in vivo

Drugs of the Future

Volumn 26, Issue 7, 2001, Pages 669-676

  Shechter, Y ^a   Goldwaser, I ^a   Lavon, I ^a   Gershonov, E ^a   Mester, B ^a   Mironchik, M ^a   Patt, L P ^a   Fridkin, M ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

9 FLUORENYLMETHYL CHLOROFORMATE; ALPHA2 INTERFERON; GLUCAGON; GLUCOSE; HUMAN INSULIN; INSULIN; ISOPHANE INSULIN; PEPTIDE; PROTEIN;

ANIMAL EXPERIMENT; BLOOD SAMPLING; CONJUGATE; CONTROLLED STUDY; DRUG HALF LIFE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; RAT; REVIEW; SOLUBILITY;

EID: 0034762854     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2001.026.07.858711     Document Type: Review

References (24)

1. Insulin, oral hypoglycemic agents and the pharmacology of the endocrine pancreas
2. Insulin, oral hypoglycemic agents and the pharmacology of the endocrine pancreas
3. Insulin analogues and nasal insulin delivery
4. Pharmacokinetic considerations of new insulin formulations and routes of administration
5. Insulin glargine
6. Soluble, fatty acid acylated insulins bind to albumin and show protracted action in pigs
7. Insulin-degradation: Mechanisms, products, and significance
8. Insulin degradation in vitro and in vivo: A comparative study in men. Evidence that immunoprecipitable, partially rebindable degradation products are released from cells and circulate in blood
9. Insulin: The structure in the crystal and its reflection in chemistry and biology
10. First-pass hepatic extraction and metabolic effects of insulin and insulin analogues
11. Biologic and clinical importance of proinsulin
12. The 9-fluorenylmethoxycarbonyl amino-protecting group
13. The 9-fluorenylmethyloxycarbonyl family of base-sensitive amino-protecting groups
14. New concept for long-acting insulin, spontaneous conversion of an inactive modified insulin to the active hormone in circulation: 9-Fluorenylmethyloxycarbonyl derivative of insulin
15. Insulin analoges and their potential management of diabetes mellitus
16. 3-insulin
17. Pharmacokinetics: The dynamics of drug absorption, distribution and elimination
18. Long-term efficacy of treatment of chronic hepatitis with alpha interferon or alpha interferon and ribavirin
19. Interferon alfa for chronic hepatitis B infection: Increased efficacy of prolonged treatment. The European Concerted Action on Viral Hepatitis (EUROHEP)
20. Interferon and other biologic agents for the treatment of Kaposi's sarcoma
21. Hairy-cell leukemia and alfa-interferon treatment: Long-term responders
22. 7 interferon-alpha2
23. Ligand binding to albumin
24. Structure of serum albumin