Repertoire and immunofocusing of CD8 T cell responses generated by HIV-1 gag-pol and expression library immunization vaccines

Journal of Immunology

Volumn 173, Issue 7, 2004, Pages 4387-4393

  Singh, Rana A K ^a   Barry, Michael A ^a,b,c  

^a RICE UNIVERSITY   (United States)

^b Rice University   (United States)

^c CENTER FOR CELL AND GENE THERAPY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CYTOKINE; EPITOPE; EXPRESSION LIBRARY IMMUNIZATION VACCINE; GAG PROTEIN; GAMMA INTERFERON; HLA A ANTIGEN; HLA A2 ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; PLASMID DNA; POL PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG; VIRUS ANTIGEN; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA LIBRARY; EXPRESSION LIBRARY IMMUNIZATION; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNIZATION; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; SPLEEN CELL; TRANSGENIC MOUSE; VIRUS INFECTION;

EID: 4644291307     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.7.4387     Document Type: Article

References (18)

1. Amara, R. R., F. Villinger, J. D. Altman, S. L. Lydy, S. P. O'Neil, S. I. Staprans, D. C. Montefiori, Y. Xu, J. G. Herndon, L. S. Wyatt, et al. 2001. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science 292:69.
2. Shiver, J. W., T. M. Fu, L. Chen, D. R. Casimiro, M. E. Davies, R. K. Evans, Z. Q. Zhang, A. J. Simon, W. L. Trigona, S. A. Dubey, et al. 2002. Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature 415:331.
3. Barouch, D. H., S. Santra, J. E. Schmitz, M. J. Kuroda, T. M. Fu, W. Wagner, M. Bilska, A. Craiu, X. X. Zheng, G. R. Krivulka, et al. 2000. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science 290:486.
4. Barouch, D. H., A. Craiu, S. Santra, M. A. Egan, J. E. Schmitz, M. J. Kuroda, T. M. Fu, J. H. Nam, L. S. Wyatt, M. A. Lifton, et al. 2001. Elicitation of high-frequency cytotoxic T-lymphocyte responses against both dominant and subdominant simian-human immunodeficiency virus epitopes by DNA vaccination of rhesus monkeys. J. Virol. 75:2462.
5. Santra, S., D. H. Barouch, M. J. Kuroda, J. E. Schmilz, G. R. Krivulka, K. Beaudry, C. I. Lord, M. A. Lifton, L. S. Wyatt, B. Moss, et al. 2002. Prior vaccination increases the epitopic breadth of the cytotoxic T-lymphocyte response that evolves in rhesus monkeys following a simian-human immunodeficiency virus infection. J. Virol. 76:6376.
6. Barouch, D. H., J. Kunstman, M. J. Kuroda, J. E. Schmilz, S. Santra, F. W. Peyerl, G. R. Krivulka, K. Beaudry, M. A. Lifton, D. A. Gorgone, et al. 2002. Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes. Nature 415:335.
7. Tobery, T. W., and R. F. Siliciano. 1997. Targeting of HIV-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction of de novo CTL responses in vivo after immunization. J. Exp. Med. 185:909.
8. Rodriguez, D., J. R. Rodriguez, M. Llorente, I. Vazquez, P. Lucas, M. Esteban, A. C. Martinez, and G. del Real. 1999. A human immunodeficiency virus type 1 Env-granulocyte-macrophage colony-stimulating factor fusion protein enhances the cellular immune response to Env in a vaccinia virus-based vaccine. J. Gen. Virol. 80:217.
9. Sykes, K. F., and S. A. Johnston. 1999. Genetic live vaccines mimic the anti-genicity but not pathogenicity of live viruses. DNA Cell Biol. 18:521.
10. Barry, M. A., W. C. Lai, and S. A. Johnston. 1995. Protection against mycoplasma infection using expression library immunization: a general approach to vaccine development. Nature 377:632.
11. Singh, R. A., L. Wu, and M. A. Barry. 2002. Generation of genome-wide CD8 T cell responses in HLA-A*0201 transgenic mice by an HIV-1 ubiquitin expression library immunization vaccine. J. Immunol. 168:379.
12. Vitiello, A., D. Marchesini, J. Furze, L. A. Sherman, and R. W. Chesnut. 1991. Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex. J. Exp. Med. 173:1007.
13. Casimiro, D. R., L. Chen, T. M. Fu, R. K. Evans, M. J. Caulfield, M. E. Davies, A. Tang, M. Chen, L. Huang, V. Harris, et al. 2003. Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene. J. Virol. 77:6305.
14. Molla, A., M. Korneyeva, Q. Gao, S. Vasavanonda, P. J. Schipper, H. M. Mo, M. Markowitz, T. Chernyavskiy, P. Niu, N. Lyons, et al. 1996. Ordered accumulation of mutations in HIV protease confers resistance to ritonavir. Nat. Med. 2:760.
15. Condra, J. H. 1998. Resistance to HIV protease inhibitors. Haemophilia 4:610.
16. Tisdale, M., R. E. Myers, B. Maschera, N. R. Parry, N. M. Oliver, and E. D. Blair. 1995. Cross-resistance analysis of human immunodeficiency virus type I variants individually selected for resistance to five different protease inhibitors. Antimicrob. Agents Chemother. 39:1704.
17. Schock, H. B., V. M. Garsky, and L. C. Kuo. 1996. Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials: compensatory modulations of binding and activity. J. Biol. Chem. 271:31957.
18. Andersson, H. A., and M. A. Barry. 2004. Maximizing proteasome targeting for gene-based vaccines. Mol. Ther. 10:24.