Reduction of pneumococcal nasopharyngeal carriage in early infancy after immunization with tetravalent pneumococcal vaccines conjugated to either tetanus toxoid or diphtheria toxoid

Pediatric Infectious Disease Journal

Volumn 16, Issue 11, 1997, Pages 1060-1064

  Dagan, Ron ^a,b   Muallem, Marie ^a   Melamed, Rimma ^a   Leroy, Odile ^c   Yagupsky, Pablo ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c NONE

Author keywords

Carriage; Colonization; Conjugate vaccines; Immunization; Infants; Streptococcus pneumoniae

Indexed keywords

ANTIBIOTIC AGENT; ANTIBODY; DIPHTHERIA TOXOID; ETHYLHYDROCUPREINE; OXACILLIN; PENICILLIN DERIVATIVE; PNEUMOCOCCUS VACCINE; POLYSACCHARIDE; TETANUS TOXOID;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM CARRIER; BACTERIUM CULTURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG CONJUGATION; FEMALE; HUMAN; IMMUNIZATION; INFANT; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX; PRIORITY JOURNAL; SEROLOGY; SEROTYPE; STREPTOCOCCUS INFECTION;

BACTERIAL VACCINES; CARRIER STATE; DIPHTHERIA TOXOID; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IMMUNIZATION; INFANT; MALE; NASOPHARYNX; PNEUMOCOCCAL VACCINES; STREPTOCOCCUS PNEUMONIAE; TETANUS TOXOID; VACCINES, CONJUGATE;

EID: 0030656236     PISSN: 08913668     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006454-199711000-00011     Document Type: Article

References (30)

1. Dagan R, Yagupsky P, Golbart A, Wasas A, Klugman K. Increasing prevalence of penicillin-resistant pneumococcal infections in children in southern Israel: implications for future immunization policies. Pediatr Infect Dis J 1994;13: 782-6.
2. Klugman KP. Pneumococcal resistance to antibiotics. Clin Microbiol Rev 1990;3:171-96.
3. Breiman RF, Butler JC, Tenover FC, Elliot JA, Facklam RR. Emergence of drug-resistant pneumococcal infections in the United States. JAMA 1994;271:1831-5.
4. Stein KE. Thymus-independent and thymus-dependent responses to polysaccharide antigens. J Infect Dis 1992;165: S49-52.
5. Klein DL. Pneumococcal conjugate vaccines: review and update. Microbial Drug Resistance 1995;1:48-59.
6. Mohle-Boetani JC, Ajello G, Breneman E, et al. Carriage of Haemophilus influenzae type b in children after widespread vaccination with conjugate Haemophilus influenzae type b vaccines. Pediatr Infect Dis J 1993;12:589-93.
7. Murphy TV, Pasto P, Medley F, Osterholm MT, Granoff DM. Decreased Haemophilus colonization in children vaccinated with Haemophilus influenzae type b conjugate vaccine. J Pediatr 1993;122:517-23.
8. Takala AK, Santosham M, Almeido-Hill J, et al. Vaccination with Haemophilus influenzae type b meningococcal protein conjugate vaccine reduces oropharyngeal carriage of Haemophilus influenzae type b among American Indian children. Pediatr Infect Dis J 1993;12:593-9.
9. Takala AK, Eskola J, Leinonen M, et al. Reduction in oropharyngeal carriage of Haemophilus influenzae type b (Hib) in children immunized with an Hib conjugate vaccine. J Infect Dis 1991;164:982-6.
10. Barbour ML, Mayon-White RT, Crook DW, Coles C, Moxon ER. The influence of Haemophilus influenzae type b conjugate vaccine (PRP-T) on oropharyngeal carriage of Haemophilus influenzae type b in infants under 12 months of age [Abstract 304]. In: Programs and abstracts of the 33rd Interscience Conference of Antimicrobial Agents and Chemotherapy, New Orleans, October 18 to 20, 1993. Washington, DC: American Society for Microbiology, 1993.
11. Barbour ML. Conjugate vaccines and the carriage of Haemophilus influenzae type b. Emerging Infect Dis 1996;2:1-8.
12. Munford RS, Murphy TV. Antimicrobial resistance in Streptococcus pneumoniae: can immunization prevent its spread? J Invest Med 1994;42:613-21.
13. Austrian R. Confronting drug-resistant pneumococci. Ann Intern Med 1994;121:807-9.
14. Dagan R, Melamed R, Muallem M, et al. Reduction of nasopharyngeal carriage of pneumococci during the second year of life by a heptavalent conjugate pneumococcal vaccine. J Infect Dis 1996;174:1271-8.
15. Dagan R, Melamed R, Zamir O, Leroy O. Safety and immunogenicity of tetravalent pneumococcal vaccines containing 6B, 14, 19F and 23F polysaccharides conjugated to either tetanus toxoid or diphtheria toxoid in young infants and their boosterability by native polysaccharide antigens. Pediatr Infect Dis J 1997:16:1053-9.
16. Austrian R. The quellung reaction, a neglected microbiologic technique. Mt Sinai J Med 1976;43:669-705.
17. Streptococci, including enterococci and pneumococci and aerococcus. In: Baron E, Feingold S, eds. Bailey and Scott's diagnostic microbiology. 8th ed. St. Louis: Mosby-Year Book, 1990:333-52.
18. Jacobs MR, Bajaksouzian S, Appelbaum PC, Bolstrom A. Evaluation of the E-test for susceptibility testing of pneumococci. Diagn Microbiol Infect Dis 1992;15:473-8.
19. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial susceptibility testing: fifth informed supplement. NCCLS document M100-S5. vol 14, no 16. Villanova, PA: National Committee for Clinical Laboratory Standards, 1994.
20. Giebink SG, Meier JD, Quartey MK, Liebeler CL, Chap TL. Immunogenicity and efficacy of Streptococcus pneumoniae polysaccharide-protein conjugate vaccines against homologous and heterologous serotypes in the chinchilla otitis media model. J Infect Dis 1996;173:119-27.
21. Dagan R, Melamed R, Muallem M, Piglansky L, Yagupsky P. Nasopharyngeal colonization in southern Israel with antibiotic-resistant pneumococci during the first 2 years of life: relation to serotypes likely to be included in pneumococcal conjugate vaccines. J Infect Dis 1996;174:1352-5.
22. Dagan R, Prajgrod F, Fraser D, Gorodnizki Z, Yagupsky P. Carriage of resistant pneumococci in a day care center in southern Israel [Abstract J63]. In: Program and abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, FL, October 4 to 7, 1994. Washington, DC: American Society of Microbiology, 1994.
23. Gwaltney JM, Sande MA, Austrian R, Hendley JO. Spread of Streptococcus pneumoniae in families. II. Relation of transfer of S. pneumoniae to incidence of colds and serum antibody. J Infect Dis 1975;132:62-8.
24. Duchin JS, Breiman RF, Diamond A, et al. High prevalence of multidrug-resistant Streptococcus pneumoniae among children in a rural Kentucky community. Pediatr Infect Dis J 1995;14:745-50.
25. Reichler MR, Allphin AA, Breiman RF, et al. The spread of multiply resistant Streptococcus pneumoniae at a day care center in Ohio. J Infect Dis 1992;166:1346-53.
26. Appelbaum PC. Antimicrobial resistance in Streptococcus pneumoniae: an overview. Clin Infect Dis 1992;15:77-83.
27. Gray BM, Turner ME, Dillon HC Jr. Epidemiologic studies of Streptococcus pneumoniae in infants: the effects of season and age on pneumococcal acquisition and carriage in the first 24 months of life. Am J Epidemiol 1982;116:692-703.
28. Musher DM. Infections caused by Streptococcus pneumoniae: clinical spectrum, pathogenesis, immunity and treatment. Clin Infect Dis 1992;14:801-9.
29. Hendley JO, Sande MA, Stewart PM, Gwaltney JM. Spread of Streptococcus pneumoniae in families: carriage rates and distribution of types. J Infect Dis 1975;132:55-61.
30. Kauppi M, Eskola J, Käyhty H. Anti-capsular polysaccharide antibody concentrations in saliva after immunization with Haemophilus influenzae type b conjugate vaccines. Pediatr Infect Dis J 1995;14:286-94.Nov., 1997