The effects of graded doses of endothelin-1 on coronary perfusion pressure and vital organ blood flow during cardiac arrest

Academic Emergency Medicine

Volumn 7, Issue 3, 2000, Pages 211-221

  Debehnke, Daniel ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Blood flow; Cardiac arrest; Cardiopulmonary resuscitation; Coronary perfusion pressure; Endothelin

Indexed keywords

ADRENALIN; ENDOTHELIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY CONSTRICTION; DOSE RESPONSE; DRUG EFFECT; HEART ARREST; HEART MUSCLE BLOOD FLOW; HEART VENTRICLE FIBRILLATION; NONHUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL; RESUSCITATION; SWINE;

EID: 0034090582     PISSN: 10696563     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1553-2712.2000.tb01061.x     Document Type: Article

References (24)

1. Niemann JT, Rosborough JP, Ung S, Criley JM. Coronary perfusion pressure during experimental cardiopulmonary resuscitation. Ann Emerg Med. 1982; 11:127-31.
2. Paradis NA, Martin GB, Rivers EP, et al. Coronary perfusion pressure and the return of spontaneous circulation in human cardiopulmonary resuscitation. JAMA. 1990; 263:1106-13.
3. Brown CG, Martin DR, Pepe PE, et al. A comparison of standard-dose and high-dose epinephrine in cardiac arrest outside the hospital. N Engl J Med. 1992; 327:1051-5.
4. Stiell IG, Hebert PC, Weitzman BN, et al. High-dose epinephrine in adult cardiac arrest. N Engl J Med. 1992; 327: 1045-50.
5. Ditchey RV, Lindenfeld J. Failure of epinephrine to improve the balance between myocardial oxygen supply and demand during closed chest resuscitation in dogs. Circulation. 1988; 78: 382-9.
6. Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988; 332:411-5.
7. Masaki T. Endothelins: homeostatic and compensatory actions in the circulatory and endocrine systems. Endocr Rev. 1993; 14:256-68.
8. Luscher TF. Endothelin: systemic arterial and pulmonary effects of a new peptide with potent biologic properties. Am Rev Respir Dis. 1992; 146:S56-S60.
9. Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T. Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide. Eur J Physiol. 1988; 413: 108-10.
10. Moravec CS, Reynolds EE, Stewart RW, Bond M. Endothelin is a positive inotropic agent in human and rat heart in vitro. Biochem Biophys Res Commun. 1989; 159(1):14-8.
11. Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T. Positive inotropic action of novel vasoconstrictor peptide endothelin on guinea pig atria. Am J Physiol. 1988; 255:970-3.
12. DeBehnke DJ, Spreng D, Wickman LL, Crowe DT. The effects of endothelin-1 on coronary perfusion pressure during cardiopulmonary resuscitation in a canine model. Acad Emerg Med. 1996; 3:137-41.
13. Yang L, Weil MH, Noc M, Tang W, Turner T, Gazmuri RJ. Spontaneous gasping increases the ability to resuscitate during experimental cardiopulmonary resuscitation. Crit Care Med. 1994; 22:879-83.
14. Kolenda D, et al. IMT ON TRAC 1994. FASEB J. (RBF Suppl).
15. Holzer M, Behringer W, Sterz F, et al. Dose dependent increase of cerebral blood flow with endothelin-1 during Advanced Cardiac Life Support in pigs [abstract]. Resuscitation. 1998; 37(2):S12.
16. Holzer M, Behringer W, Sterz F, et al. Higher cerebral blood flow with endothelin-1 as compared to epinephrine during Advanced Cardiac Life Support in pigs [abstract]. Resuscitation. 1998; 37(2):S13.
17. Walder CE, Thomas GR, Thiemermann C, Vane JR. The hemodynamic effects of endothelin-1 in the pithed rat. J Cardiovasc Pharmacol. 1989; 13(5, suppl):S93-S97.
18. Pernow J, Franco-Cereceda A, Matran R, Lundberg JM. Effect of endothelin-1 on regional vascular resistances in the pig. J Cardiovasc Pharmacol. 1989; 13(5, suppl):S205-S206.
19. Gillespie MN, Owasoyo JO, McMurtry IF, O'Brien RF. Sustained coronary vasoconstriction provoked by a peptidergic substance released from endothelial cells in culture. J Pharmacol Exp Ther. 1986; 236:339-43.
20. Huggins JP, Pelton JT, Miller RC. The structure and specificity of endothelin receptors: their importance in physiology and medicine. Pharmacol Ther. 1993; 59:55-123.
21. B receptors mediate contraction to endothelin-1 in human blood vessels. Circulation. 1994; 89:1203-8.
22. B receptors cause vasoconstriction of human resistance and capacitance vessels in vivo. Circulation. 1995; 92:357-63.
23. Ishikawa K, Ihara M, Noguchi K, et al. Biochemical and pharmacological profile of a potent and selective endothelin β-receptor antagonist, BQ-788. Proc Natl Acad Sci USA. 1994; 91:4892-6.
24. B2 receptors, BQ-788: effects on blood vessel and small intestine. Biochem Biophys Res Commun. 1994; 205:168-73.