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Lanthanides are ideal calcium analogs due to the chemical similarities of the ions, including ionic radii, coordination environments and ligand preferences. The ionic radius of Ca(II) ion is 0.99 Å, and the ionic radii of lanthanides range from 0.86 to 1.22 Å. Coordination numbers of calcium ion vary from 6 to 8, and those of lanthanide ions typically range from 8 to 9. In addition, both calcium and lanthanide ions have a strong preference for hard oxygen donor ligands, and can adopt flexible geometries mainly governed by steric factors. As such, the lanthanide ions can substitute for calcium in proteins with minimal structural changes.
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