Resistance of Entamoeba histolytica to the cysteine proteinase inhibitor E64 is associated with secretion of pro-enzymes and reduced pathogenicity

Journal of Biological Chemistry

Volumn 279, Issue 37, 2004, Pages 38260-38266

  Nowak, Nicolas ^a   Lotter, Hannelore ^a   Tannich, Egbert ^a   Bruchhaus, Iris ^a  

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CONCENTRATION (PROCESS); ENZYMES; GENES; MUTAGENESIS;

ANTIPARASITIC DRUGS; CYSTEINE PROTEINASE (CP);

PROTEINS;

CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE;

AMEBIASIS; ARTICLE; CHO CELL; CONTROLLED STUDY; ENTAMOEBA; ENTAMOEBA HISTOLYTICA; ENZYME ASSAY; ENZYME RELEASE; GROWTH INHIBITION; INTESTINE PARASITE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; NORTHERN BLOTTING; PARASITE VIRULENCE; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTOZOAL INFECTION; TROPHOZOITE;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL DIVISION; CHO CELLS; CRICETINAE; CULTURE MEDIA; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENTAMOEBA HISTOLYTICA; GERBILLINAE; LEUCINE; LIVER; LIVER ABSCESS, AMEBIC; MICROSCOPY, ELECTRON; MUTATION; RNA; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS;

ENTAMOEBA; ENTAMOEBA HISTOLYTICA; GERBILLINAE; PROTOZOA;

EID: 4644261910     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M405308200     Document Type: Article

References (51)

1. McKerrow, J. H. (1989) Exp. Parasitol. 68, 111-115
2. Sajid, M., and McKerrow, J. H. (2002) Mol. Biochem. Parasitol. 120, 1-21
3. Cazzulo, J. J. (2002) Curr. Top. Med. Chem. 2, 1261-1271
4. Caffrey, C. R., Scory, S., and Steverding, D. (2000) Curr. Drug Targets 1, 155-162
5. McKerrow, J. H. (1999) Int. J. Parasitol. 29, 833-837
6. Bailly, E., Jambou, R., Savel, J., and Jaureguiberry, G. (1992) J. Protozool. 39, 593-599
7. Rosenthal, P. J., Lee, G. K., and Smith, R. E. (1993) J. Clin. Investig. 91, 1052-1056
8. Rosenthal, P. J., McKerrow, J. H., Aikawa, M., Nagasawa, H., and Leech, J. H. (1988) J. Clin. Investig. 82, 1560-1566
9. Rosenthal, P. J., Olson, J. E., Lee, G. K, Palmer, J. T., Klaus, J. L., and Rasnick, D. (1996) Antimicrob. Agents Chemother. 40, 1600-1603
10. Rosenthal, P. J., Wollish, W. S., Palmer, J. T., and Rasnick, D. (1991) J. Clin. Investig. 88, 1467-1472
11. Olson, J. E., Lee, G, K., Semenov, A., and Rosenthal, P. J. (1999) Bioorg. Med. Chem. 7, 633-638
12. Troeberg, L., Morty, R. E., Pike, R. N., Lonsdale-Eccles, J. D., Palmer, J. T., McKerrow, J. H., and Coetzer, T. H. (1999) Exp. Parasitol. 91, 349-355
13. Ashall, F., Angliker, H., and Shaw, E. (1990) Biochem. Biophys. Res. Commun. 170, 923-929
14. Engel, J. C., Doyle, P. S., Palmer, J., Hsieh, I., Bainton, D. F., and McKerrow, J. H. (1998) J. Cell Sci. 111, 597-606
15. Mbawa, Z. R., Gumm, I. D., Shaw, E., and Lonsdale-Eccles, J. D. (1992) Eur. J. Biochem. 204, 371-379
16. Harth, G., Andrews, N., Mills, A. A., Engel, J. C., Smith, R., and McKerrow, J. H. (1993) Mol. Biochem. Parasitol. 58, 17-24
17. Meirelles, M. N., Juliano, L., Carmona, E., Suva, S. G., Costa, E. M., Murta, A. C., and Scharfstein, J. (1992) Mol. Biochem. Parasitol. 52, 175-184
18. Selzer, P. M., Pingel, S., Hsieh, L, Ugele, B., Chan, V. J., Engel, J. C., Bogyo, M., Russell, D. G., Sakanari, J. A., and McKerrow, J. H. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11015-11022
19. Scory, S., Caffrey, C. R., Stierhof, Y. D., Ruppel, A., and Steverding, D. (1999) Exp. Parasitol. 91, 327-333
20. Bruchhaus, L, Loftus, B. J., Hall, N., and Tannich, E. (2003) Eukaryot. Cell 2, 501-509
21. Stanley, S. L., Jr., Zhang, T., Rubin, D., and Li, E. (1995) Infect. Immun. 63, 1587-1590
22. Li, E., Yang, W. G., Zhang, T., and Stanley, S. L., Jr. (1995) Infect. Immun. 63, 4150-4153
23. Ankri, S., Stolarsky, T., and Mirelman, D. (1998) Mol. Microbiol. 28, 777-785
24. Ankri, S., Stolarsky, T., Bracha, R., Padilla-Vaca, F., and Mirelman, D. (1999) Infect. Immun. 67, 421-422
25. Zhang, Z., Wang, L., Seydel, K. B., Li, E., Ankri, S., Mirelman, D., and Stanley, S. L., Jr. (2000) Mol. Microbiol. 37, 542-548
26. Wassmann, C., Hellberg, A., Tannich, E., and Bruchhaus, I. (1999) J. Biol. Chem. 274, 26051-26056
27. Samarawickrema, N. A., Brown, D. M., Upcroft, J. A., Thammapalerd, N., and Upcroft, P. (1997) J. Antimicrob. Chemother. 40, 833-840
28. Blessmann, J., Ali, I.K., Nu, P.A., Dinh, B.Z., Viet, T.Q., Van, A.L., Clark, C.G., and Tannich, E. (2003) J. Clin. Microbiol. 41, 4745-4750
29. Gathiram, V., and Jackson, T. F. (1987) S. Afr. Med. J. 72, 669-672
30. Blessmann, J., and Tannich, E. (2002) N. Engl. J. Med. 347, 1384
31. Diamond, L. S., Harlow, D. R., and Cunnick, C. C. (1978) Trans. R. Soc. Trop. Med. Hyg. 72, 431-432
32. Jacobs, T., Bruchhaus, L, Dandekar, T., Tannich, E., and Leippe, M. (1998) Mol. Microbiol. 27, 269-276
33. Hellberg, A., Leippe, M., and Bruchhaus, I. (2000) Mol. Biochem. Parasitol. 105, 305-309
34. Leippe, M., Sievertsen, H. J., Tannich, E., and Horstmann, R. D. (1995) Parasitology 111, 569-574
35. Bracha, R., and Mirelman, D. (1984) J. Exp. Med. 160, 353-368
36. Hohenberg, H., Mannweiler, K., and Muller, M. (1994) J. Microsc. 175, 34-43
37. Bente, M., Harder, S., Wiesgigl, M., Heukeshoven, J., Gelhaus, C., Krause, E., Clos, J., and Bruchhaus, I. (2003) Proteomics 3, 1811-1829
38. Lotter, H., Zhang, T., Seydel, K. B., Stanley, S. L., Jr., and Tannich, E. (1997) J. Exp. Med. 185, 1793-1801
39. Hellberg, A., Nickel, R., Lotter, H., Tannich, E., and Bruchhaus, I. (2001) Cell Microbiol. 3, 13-20
40. Barrett, A. J., and Kirschke, H. (1981) Methods Enzymol. 80, 535-561
41. Green, G. D., and Shaw, E. (1981) J. Biol. Chem. 256, 1923-1928
42. Luaces, A. L., and Barrett, A. J. (1988) Biochem. J. 250, 903-909
43. Scholze, H., and Schulte, W. (1988) Biomed. Biochim. Acta 47, 115-123
44. Wilcox, D., and Mason, R. W. (1992) Biochem. J. 285, 495-502
45. Borst, P., and Ouellette, M. (1995) Anna. Rev. Microbiol. 49, 427-460
46. Cowman, A. F. (1995) Aust. N. Z. J. Med. 25, 837-844
47. Barrett, M. P., and Fairlamb, A. H. (1999) Parasitol. Today 15, 136-140
48. Perez-Victoria, J. M., Di Pietro, A., Barron, D., Ravelo, A. G., Castanys, S., and Gamarro, F. (2002) Curr. Drug Targets 3, 311-333
49. Engel, J. C., Torres, C., Hsieh, I., Doyle, P. S., McKerrow, J. H., and Garcia, C. T. (2000) J. Cell Sci. 113, 1345-1354
50. Bruchhaus, I., Jacobs, T., Leippe, M., and Tannich, E. (1996) Mol. Microbiol. 22, 255-263
51. Willhoeft, U., Hamann, L., and Tannich, E. (1999) Infect. Immun. 67, 5925-5929