ERβ sensitizes breast cancer cells to retinoic acid: Evidence of transcriptional crosstalk

Molecular Cancer Research

Volumn 2, Issue 9, 2004, Pages 523-531

  Rousseau, Caroline ^a   Nichol, Jessica N ^a   Pettersson, Filippa ^a   Couture, Marie Claude ^a   Miller Jr , Wilson H ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR BETA; FULVESTRANT; RETINOIC ACID; RETINOIC ACID RECEPTOR BETA; TAMOXIFEN; RETINOIC ACID RECEPTOR; TRANSCRIPTION FACTOR AP 1;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CELL NUCLEUS; CELL STRAIN; CELL STRAIN MDA MB 231; CONTROLLED STUDY; DRUG EFFECT; DRUG SENSITIZATION; ESTROGEN RESPONSIVE ELEMENT; EVIDENCE BASED MEDICINE; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PS2 GENE; RETROVIRUS; WESTERN BLOTTING; BREAST TUMOR; CELL PROLIFERATION; DNA RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; METABOLISM; TRANSACTIVATION; TUMOR CELL LINE;

UNIDENTIFIED RETROVIRUS;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; ESTROGEN RECEPTOR BETA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; RECEPTORS, RETINOIC ACID; RESPONSE ELEMENTS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-1; TRANSFECTION; TRETINOIN;

EID: 4644257763     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Kuiper GG, Enmaik E, Pelto-Huikko M, Nilsson S, Gustafsson JA. Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 1996;93:5925-30.
2. Mosselman S, Polman J, Dijkema R. ERβ: identification and characterization of a novel human estrogen receptor. FEBS Lett 1996;392:49-53.
3. Dechering K, Boersma C, Mosselman S. Estrogen receptors α and β: two receptors of a kind? Curr Med Chem 2000;7:561-76.
4. Lazennec G, Bresson D, Lucas A, Chauveau C, Vignon F. ERβ inhibits proliferation and invasion of breast cancer cells. Endocrinology 2001;142:4120-30.
5. Couse JF, Korach KS. Estrogen receptor null mice: what have we learned and where will they lead us? Endocr Rev 1999;20:358-417.
6. Nilsson S, Makela S, Treuter E, et al. Mechanisms of estrogen action. Physiol Rev 2001;81:1535-65.
7. Jarvinen TA, Pelto-Huikko M, Holli K, Isola J. Estrogen receptor β is coexpressed with ERα and PR and associated with nodal status, grade, and proliferation rate in breast cancer. Am J Pathol 2000;156:29-35.
8. Speirs V, Parkes AT, Kerin MJ, et al. Coexpression of estrogen receptor α and β: poor prognostic factors in human breast cancer? Cancer Res 1999;59:525-8.
9. Slack JL. Biology and treatment of acute progranulocytic leukemia. Curr Opin Hematol 1999;6:236-40.
10. Rubin M, Fenig E, Rosenauer A, et al. 9-Cis retinoic acid inhibits growth of breast cancer cells and down-regulates estrogen receptor RNA and protein. Cancer Res 1994;54:6549-56.
11. 1 arrest in human MCF-7 breast cancer cells. Br J Cancer 1998;77:186-91.
12. Zhu WY, Jones CS, Kiss A, Matsukuma K, Amin S, De Luca LM. Retinoic acid inhibition of cell cycle progression in MCF-7 human breast cancer cells. Exp Cell Res 1997;234:293-9.
13. Bischoff ED, Gottardis MM, Moon TE, Heyman RA, Lamph WW. Beyond tamoxifen: the retinoid-X-receptor-selective ligand LGD1069 (Targretin) causes complete regression of mammary carcinoma. Cancer Res 1998;58:479-84.
14. Gottardis MM, Lamph WW, Shalinsky DR, Wellstein A, Heyman RA. The efficacy of 9-cis retinoic acid in experimental models of cancer. Breas Cancer Res Treat 1996;38:85-96.
15. Thompson HJ, Becci PJ, Moon RC, et al. Inhibition of 1-methyl-1- nitrosurea-induced mammary carcinogenesis in the rat by the retinoid axerophthene. Arzneimittelforschung 1980;30:1127-9.
16. Hunter DJ, Manson JE, Colditz GA, et al. A prospective study of the intake of vitamins C, E, and A and the risk of breast cancer. N Engl J Med 1993;329:234-40.
17. Veronesi U, De Palo G, Marubini E, et al. Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer. J Natl Cancer Inst 1999;91:1847-56.
18. Evans RM. The steroid and thyroid hormone receptor superfamily. Science 1988;240:889-95.
19. Sheikh MS, Shao ZM, Li XS, et al. N-(4-hydroxyphenyl)retinamide (4-HPR)-mediated biological actions involve retinoid receptor-independent pathways in human breast carcinoma. Carcinogenesis 1995;16:2477-86.
20. Rosenauer A, Nervi C, Davison K, Lamph WW, Mader S, Miller WH Jr. Estrogen receptor expression activates the transcriptional and growth-inhibitory response to retinoids without enhanced retinoic acid receptor α expression. Cancer Res 1998;58:5110-6.
21. Rousseau C, Pettersson F, Couture MC, et al. The N-terminal of the estrogen receptor (ERα) mediates transcriptional cross-talk with the retinoic acid receptor in human breast cancer cells. J Steroid Biochem Mol Biol 2003;86:1-14.
22. Jiang SY, Jordan VC. Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor. J Natl Cancer Inst 1992;84:580-91.
23. Lundholt BK, Briand P, Lykkesfeldt AE. Growth inhibition and growth stimulation by estradiol of estrogen receptor transfected human breast epithelial cell lines involve different pathways. Breast Cancer Res Treat 2001;67:199-214.
24. Fontana JA, Nervi C, Shao ZM, Jetten AM. Retinoid antagonism of estrogen-responsive transforming growth factor α and pS2 gene expression in breast carcinoma cells. Cancer Res 1992;52:3938-45.
25. Pratt MA, Deonarine D, Teixeira C, Novosad D, Tale BF, Grippo JF. The AF-2 region of the retinoic acid receptor α mediates retinoic acid inhibition of estrogen receptor function in breast cancer cells. J Biol Chem 1996;271:20346-52.
26. Tibaduiza EC, Fleet JC, Russell RM, Krinsky NI. Eccentric cleavage products of β-carotene inhibit estrogen receptor positive and negative breast tumor cell growth in vitro and inhibit activator protein-1-mediated transcriptidnal activation, J Nutr 2002;132:1368-75.
27. Agadir A, Chen G, Bost F, Li Y, Mercola D, Zhang X. Differential effect of retinoic acid on growth regulation by phorbol ester in human cancer cell lines. J Biol Chem 1999;274:29779-85.
28. Paech K, Webb P, Kuiper GG, et al. Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites. Science 1997;277:1508-10.
29. Schneider SM, Offterdinger M, Huber H, Grunt TW. Activation of retinoic acid receptor α is sufficient for full induction of retinoid responses in SK-BR-3 and T47D human breast cancer cells. Cancer Res 2000;60:5479-87.
30. Fitzgerald P, Teng M, Chandraratna RA, Heyrhan RA, Allegretto EA. Retinoic acid receptor α expression correlates with retinoid-induced- growth inhibition of human breast cancer cells regardless of estrogen receptor status. Cancer Res 1997;57:2642-50.
31. Sirchia SM, Ren M, Pili R, et al. Endogenous reactivation of the RARβ2 tumor suppressor gene epigenetically silenced in breast cancer. Cancer Res 2002;62:2455-61. :
32. van Agthoven T, Timmermans M, Foekens JA, Dorssers LC, Henzen-Logmans SC. Differential expression of estrogen, progesterone, and epidermal growth factor receptors in normal, benign, and malignant human breast tissues using dual staining immunohistochemistry. Am J Pathol 1994;144:1238-46.
33. Speirs V. Estrogen receptor β in breast cancer good, bad or still too early to tell? J Pathol 2002;197:143-7.
34. Lacroix A, Lippman ME. Binding of retinoids to human breast cancer cell lines and their effects on cell growth. J Clin Invest 1980;65:586-91.
35. Niu MY, Menard M, Reed JC, Krajewski S, Pratt MA. Ectopic expression of cyclin D1 amplifies a retinoic acid-induced mitochondrial death pathway in breast cancer cells. Oncogene 2001;20:3506-18.
36. Zhu WY, Jones CS, Amin.S, et al. Retinoic acid increases tyrosine phosphorylation of focal adhesion kinase and paxillin in MCF-7 human breast cancer cells. Cancer Res 1999;59:85-90.
37. Veronesi U, De Palo G, Costa A, Formelli F, Decensi A. Chemoprevention of breast cancer with fenretinide. IARC Sci Publ 1996;136:87-94.
38. Tonetti DA, Rubenstern R, DeLeon M, et al. Stable transfection of an estrogen receptor β cDNA isoform into MDA-MB-231 breast cancer cells. J Steroid Biochem Mol Biol 2003;87:47-55.
39. Yang LM, Tin UC, Wu K, Brown P. Role of retinoid receptors in the prevention and treatment of breast cancer. J Mammary Gland Biol Neoplasia 1999;4:377-88.
40. Young MR, Yang HS, Colburn NH. Promising molecular targets for cancer prevention: AP-1, NF-κB and Pdcd4. Trends Mol Med 2003;9:36-41.
41. Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 2002;4:E131-6.
42. Kushner PJ, Agard DA, Greene GL, et al. Estrogen receptor pathways to AP-1. J Steroid Biochem Mol Biol 2000;74:311-7.
43. Sheikh MS, Shao ZM, Chen JC, Hussain A, Jetten AM, Fontana JA. Estrogen receptor-negative breast cancer cells transfected with the estrogen receptor exhibit increased RARα gene expression and sensitivity to growth inhibition by retinoic acid. J Cell Biochem 1993;53:394-404.
44. Sun SY, Wan H, Yue P, Hong WK, Lotan R. Evidence that retinoic acid receptor β induction by retinoids is important for tumor cell growth inhibition. J Biol Chem 2000;275:17149-53.
45. Liu G, Wu M, Levi G, Ferrari N. Inhibition of cancer cell growth by all-trans retinoic acid and its analog N-(4-hydroxyphenyl) retinamide: a possible mechanism of action via regulation of retinoid receptors expression. Int J Cancer 1998;78:248-54.
46. Lee MO, Han SY, Jiang S, Park JH, Kim SJ. Differential effects of retinoic acid on growth and apoptosis in human colon cancer cell lines associated with the induction of retinoic acid receptor β. Biochem Pharmacol 2000;59:485-96.
47. Kobayashi Y, Kitamoto T, Masuhiro Y, et al. p300 mediates functional synergism between AF-1 and AF-2 of estrogen receptor α and β by interacting directly with the N-terminal A/B domains. J Biol Chem 2000;275:15645-51.
48. Ogawa S, Inoue S, Watanabe T, et al. Molecular cloning and characterization of human estrogen receptor βcx: a potential inhibitor of estrogen action in human. Nucleic Acids Res 1998;26:3505-12.
49. Skehan P, Storeng R, Scudiero D, et al. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 1990;82:1107-12.