Estrogen receptor expression activates the transcriptional and growth- inhibitory response to retinoids without enhanced retinoic acid receptor α expression

Cancer Research

Volumn 58, Issue 22, 1998, Pages 5110-5116

  Rosenauer, Angelika ^a   Nervi, Clara ^b   Davison, Kelly ^a   Lamph, William W ^c   Mader, Sylvie ^d   Miller Jr , Wilson H ^a  

^a MCGILL UNIVERSITY   (Canada)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c LIGAND PHARMACEUTICALS INC   (United States)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; RETINOIC ACID RECEPTOR; RETINOID;

ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL CULTURE; GENETIC TRANSFECTION; HORMONAL REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL DIVISION; FEMALE; HUMANS; RECEPTORS, ESTROGEN; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION; TRETINOIN; TUMOR CELLS, CULTURED;

EID: 0032533844     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Hong, W. K., and Itri, L. M. Retinoids and human cancer. In: M. B. Sporn, A. B. Roberts, and D. S. Goodman (eds.), The Retinoids: Biology, Chemistry, and Medicine, pp. 597-630. New York: Raven Press, 1994.
2. Hunter, D. J., Manson, J. E., Colditz, G. A., Stampfer, M. J., Rosner, B., Hennekens, C. H., Speizer, F. E., and Willett, W. C. A prospective study of the intake of vitamins C, E, and A and the of breast cancer. N. Engl. J. Med., 329: 234-240, 1993.
3. Wald, N. J., Boreham, J., Hayward, J. L., and Bulbrook, R. D. Plasma retinol, β-carotene and vitamin E levels in relation to the future risk of breast cancer. Br. J. Cancer. 49: 321-324, 1984.
4. Lotan, R. Different susceptibilities of human melanoma and breast carcinoma cell lines to retinoic acid-induced growth inhibition. Cancer Res., 39: 1014-1019, 1979.
5. Lacroix, A., and Lippman, M. E. Binding of retinoids to human breast cancer cell lines and their effects on cell growth. J. Clin. Invest., 65: 586-591, 1980.
6. Fraker, L. D., Halter, S. A., and Forbes, J. T. Growth inhibition by retinol of a human breast carcinoma cell line in vitro and in athymic mice. Cancer Res., 44: 5757-5763, 1984.
7. Gudas, L. J. Retinoids, retinoid-responsive genes, cell differentiation, and cancer. Cell Growth Differ., 3: 655-662, 1993.
8. Levin, A. A., Sturzenbecker, L. J., Kazmer, S., Bosakowski, T., Huselton, C., Allenby, G., Speck, J., Kratzeisen, C., Rosenberger, M., Lovey, A., and Grippo, J. F. 9-cis-Retinoic acid stereoisomer binds and activates the nuclear receptor RXRα. Nature (Lond.), 355: 359-361, 1992.
9. Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A., Stein, R. B., Eichele, G., Evans, R. M., and Thaller, C. 9-cis-Retinoic acid is a high affinity ligand for the retinoid X receptor. Cell, 68: 397-406, 1992.
10. Rubin, M., Fenig, E., Rosenauer, A., Menendez-Botet, C., Achkar, C., Bentel, J. M., Yahalom, J., Mendelsohn, J., and Miller, W. H., Jr. 9-cis-Retinoic acid inhibits growth of breast cancer cells and down-regulates estrogen receptor RNA and protein. Cancer Res., 54: 6549-6556, 1994.
11. Fontana, J. A., Nervi, C., Shao, Z-M., and Jetten, A. M. Retinoid antagonism of estrogen-responsive transforming growth factor α and pS2 gene expression in breast carcinoma cells. Cancer Res., 52: 3938-3945, 1992.
12. van der Burg, B., van der Leede, B. M., Kwakkenbos-Isbrucker, L., Salverda, S., de Laat, S. W., and van der Saag, P. T. Retinoic acid resistance of estradiol-independent breast cancer cells coincides with diminished retinoic acid receptor function. Mol. Cell. Endocrinol., 91: 149-157, 1993.
13. Roman, S. D., Clarke, C. L., Hall, R. E., Alexander, I. E., and Sutherland, R. L. Expression and regulation of retinoic acid receptors in human breast cancer cells. Cancer Res., 52: 2236-2242, 1992.
14. Sheikh, M. S., Shao, Z., Chen, J., Hussain, A., Jetten, A. M., and Fontana, J. A. Estrogen receptor-negative breast cancer cells transfected with the estrogen receptor exhibit increased RARα gene expression and sensitivity to growth inhibition by retinoic acid. J. Cell Biochem., 53: 384-404, 1993.
15. Jiang, S., and Jordan, V. C. Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor. J. Natl. Cancer Inst. (Bethesda), 84: 580-591, 1992.
16. Darbre, P., Yates, J., Curtis, S., and King, R. J. B. Effect of estradiol on human breast cancer cells in culture. Cancer Res., 43: 349-354, 1983.
17. Chirgwin, J. M., Przybyla, A. F., MacDonald, R. J., and Rutter, W. J. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. J. Biochem., 18: 5294-5299, 1979.
18. Petkovich, M., Brand, N. J., Krust, A., and Chambon, P. A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature (Lond.), 330: 444-450, 1987.
19. Mangelsdorf, D. J., Ong, E. S., Dyck, J. A., and Evans, R. M. A nuclear receptor that identifies a novel retinoic acid response pathway. Nature (Lond.), 345: 224-229, 1990.
20. Zinn, K., DiMaio, D., and Maniatis T. Identification of two distinct regulatory regions adjacent to the human β-interferon gene. Cell, 34: 865-879, 1984.
21. Giguere, V., Ong, E., S., Segui, P., and Evans, R., M. Identification of a receptor for the morphogen retinoic acid. Nature (Lond.), 330: 624-629, 1987.
22. de Thé, H., Marchio, A., Thiollais, P., and Dejean, A. A novel steroid/thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma. Nature (Lond.), 330: 667-670, 1987.
23. Krust, A., Kastner, P., Petkovich, M., Zelent, A., and Chambon, P. A third human retinoic acid receptor, hRAR-γ. Proc. Natl. Acad. Sci. USA, 86: 5310-5314, 1989.
24. Chambon, P., Mader, S., Garnier, J-M., Staub, A., Chen, J-Y., Zacharewsi, T., Saunders, M., Nakshatri, H., Lyons, R., Kastner, P., and Leid, M. Purification, cloning, and RXR identity of the HeLa cell factor with RAR or TR heterodimerizes to bind target sequences efficiently. Cell, 68: 377-395, 1992.
25. Nervi, C., Grippo, J. F., Sherman, M. I., George, M. D., and Jetten, A. M. Identification and characterization of nuclear receptor acid-binding activity in human myeloblastic leukemia HL-60 cells. Proc. Natl. Acad. Sci. USA, 86: 5854-5858, 1989.
26. Sambrook, J., Fritsch, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.
27. Neuman, J. R., Morency, C. A., and Russian, K. O. A novel rapid assay for chloramphenicol acetyl transferase gene expression. Biotechniques, 5: 444, 1987.
28. Jing, Y., Zhang, J., Bleiweiss I. J., Waxman, S., Zelent, A., and Mira-Y-Lopez, R. Defective expression of cellular retinol binding protein type I and retinoic acid receptors α2, β2, and γ2 in human breast cancer cells. FASEB J., 10: 1064-1070, 1996.
29. Rishi, A. K., Shao, Z-M., Baumann, R. G., Li, X-S., Sheikh, M. S., Kimura, S., Bashirelahi, N., and Fontana, J. A. Estradiol regulation of the human retinoic acid receptor α gene in human breast carcinoma cells is mediated via imperfect half-palindromic estrogen response element and Sp1 motifs. Cancer Res., 55: 4999-5006, 1995.
30. Elgort, M. G., Zou, A., Marschke, K. B., and Allegretto, E. A. Estrogen and estrogen receptor antagonists stimulate transcription from the human retinoic acid receptor-α1 promoter via a novel sequence. Mol. Endocrinol., 10: 477-487, 1996.
31. Titcomb, M. W., Gottardis, M. M., Pike, J. W., and Allegretto, E. A. Sensitive and specific detection of retinoid receptor subtype proteins in cultured cell and tumor extracts. Mol. Endocrinol., 8: 870-877, 1994.
32. Sheikh, M., S., Shao, Z-M., Li X-S., Dawson, M., Jetten, A., M., Wu, S., Conley, B., A., Garcia, M., Rochefort, H., and Fontana, J., A. Retinoid-resistant estrogen-negative human breast carcinoma cells transfected with retinoic acid receptor-α acquire sensitivity to growth inhibition by retinoids. J. Biol. Chem., 269: 21440-21447, 1994.
33. Hall, R. E., Lee, C. S. L., Alexander, I. E., Shine, J., Clarke, C. L., and Sutherland, R. L. Steroid hormone receptor gene expression in human breast cancer cells: inverse relationship between oestrogen and glucocorticoid receptor messenger RNA levels. Int. J. Cancer, 46: 1081-1087, 1990.
34. Kumar, V., Green, S., Stack, G., Berry, M., Jin, J-R., and Chambon, P. Functional domains of the estrogen receptor. Cell, 51: 941-951, 1987.
35. Mader, S., Kumar, V., de Verneuil, H., and Chambon, P. Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element. Nature (Lond.), 338: 271-274, 1989.
36. Garcia, M., Derocq, D., Freiss, G., and Rochefort, H. Activation of estrogen receptor transfected into a receptor-negative breast cancer cell line decreases the metastatic and invasive potential of the cells. Proc. Natl. Acad. Sci. USA, 89: 11538-11542, 1992.
37. Tora, L., Mullick, A., Metzger, D., Ponglikitmongkol, M., Park, I., and Chambon, P. The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties. EMBO J., 8: 1981-1986, 1989.
38. Jiang, S-Y., Langan-Fahey, S. M., Stella, A. L., McCague, R., and Jordan, V. C. Point mutation of estrogen receptor (ER) in the ligand-binding domain changes the pharmacology of antiestrogens in ER-negative breast cancer cells stably expressing complementary DNAs for ER. Mol. Endocrinol., 6: 2167-2174, 1992.
39. Metzger, D., Berry, M., Ali, S., and Chambon, P. Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo. Mol. Endocrinol., 9: 579-591, 1995.
40. Zhuang, Y., Katzenellenbogen, B. S., and Shapiro, D. J. Estrogen receptor mutants which do not bind 17β-estradiol dimerize and bind to the estrogen response element in vivo. Mol. Endocrinol., 9: 457-466, 1995.
41. Aumais, J. P., Lee, H. S., Lin, R., and White, J. H. Selective interaction of hsp90 with an estrogen receptor ligand-binding domain containing a point mutation. J. Biol. Chem., 272: 12229-12235, 1997.
42. Mader, S., Leroy, P., Chen, J-Y., and Chambon, P. Multiple parameters control the selectivity of nuclear receptors for their response elements. J. Biol. Chem., 268: 591-600, 1993.
43. Segars, J. H., Marks, M. S., Hirschfeld, S., Driggers, P. H., Martinez, E., Grippo, J. F., Wahli, W., and Ozato, K. Inhibition of estrogen-responsive gene activation by the retinoid X receptor β: evidence for multiple inhibitory pathways. Mol. Cell. Biol., 13: 2258-2268, 1993.
44. Chen, J. D., and Evans, R. M. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature (Lond.), 377: 454-457, 1995.
45. Hörlein, A. J., Näär, A. M., Heinzel, T., Torchia, J., Gloss, B., Kurokawa, R., Ryan, A., Kamei, Y., Söderström, M., Glass, C. K., and Rosenfeld, M. G. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature (Lond.), 377: 397-403, 1995.
46. Anzick, S. L., Kononen, J., Walker, R. L., Azorsa, D. O., Tanner, M. M., Guan, G. S., Kallioniemi, O-P., Trent, J. M., and Meltzer, P. S. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science (Washington DC), 277: 956-968, 1997.
47. Chen, H., Lin, R. J., Schiltz, L., Chakravarti, D., Nash, A., Nagy, L., Privalsky, M. L., Nakatani, Y., and Evans, R. M. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/ p300. Cell, 90: 569-580, 1997.
48. Fraser, R. A., Rossignol, M., Heard, M., Egly, J. M., and Chambon, P. Sug1, a putative transcriptional mediator and subunit of the PA700 proteasome regulatory complex, is a DNA helicase. J. Biol. Chem., 272: 7122-7126, 1997.
49. Bauer, E. V., Zechel, C., Heery, D., Heine, M. J. S., Garnier, J. M., Vivat, V., Le Douarin, B., Gronemeyer, H., Chambon, P., and Losson, R. Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO J., 15: 110-124, 1996.
50. Voegel, J. J., Heine, M. J. S., Zechel, C., Chambon, P., and Gronemeyer, H. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J., 15: 3667-3675, 1996.
51. Kamei, Y., Xu, L., Heinzel, T., Kurokawa, R., Gloss, B., Lin, S-C., Heyman, R., Rose, D., Glass, C., and Rosenfeld, M. G. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell, 85: 1-12, 1996.
52. Torchia, J., Rose, D. W., Inostroza, J., Kamei, Y., Westin, S., Glass, C. K., and Rosenfeld, M. G. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature (Lond.), 387: 677-684, 1997.
53. 3R, but not its oncogenic variant, v-erb A, suppresses RAR-dependent transactivation by titrating out RXR. EMBO J., 12: 1343-1354, 1993.
54. Rochette-Egly, C., Oulad-Abdelghani, M., Staub, A., Pfister, V., Scheuer, I., Chambon, P., and Gaub, M-P. Phosphorylation of retinoic acid receptor-alpha by protein kinase A. Mol. Endocrinol., 9: 860-871, 1995.
55. Rochette-Egly, C., Gaub, M-P., Lutz, Y., Ali, S., Scheuer, I., and Chambon, P. Retinoic acid receptor-beta: immunodetection and phosphorylation on tyrosine residues. Mol. Endo., 6: 2197-2209, 1992.
56. Lefebvre, P., Gaub, M-P., Tahayato, A., Rochette-Egly, C., and Formstecher, P. Protein phosphatases 1 and 2A regulate the transcriptional and DNA-binding activities of retinoic acid receptors. J. Biol. Chem., 270: 10806-10816, 1995.
57. Katagiri, K., Yokoyama, K. K., Yamamoto, T., Omura, S., Irie, S., and Katagiri, T. Lyn and Fgr protein-tyrosine kinases prevent apoptosis during retinoic acid-induced granulocytic differentiation of HL-60 cells. J. Biol. Chem., 271: 11557-11562, 1996.
58. Daffada, A. A. I., Johnston, S. R. D., Smith, I. E., Detre, S., King, N., and Dowsett, M. Exon 5 deletion variant estrogen receptor messenger RNA expression in relation to tamoxifen resistance and progesterone/pS2 status in human breast cancer. Cancer Res., 55: 288-293, 1995.