6-Substituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation from N-(3-chloropyrazin-2-yl)-methanesulfonamide and alkynes

Tetrahedron Letters

Volumn 45, Issue 43, 2004, Pages 8087-8090

  Hopkins, Corey R ^a   Collar, Nicola ^a  

^a SANOFI   (France)

Author keywords

6 Substituted 5H pyrrolo 2,3 b pyrazine; Cyclization; Heteroannulation; Palladium

Indexed keywords

ALKYNE DERIVATIVE; PALLADIUM; PYRAZINE DERIVATIVE; SULFONAMIDE;

ANNULATION REACTION; ARTICLE; CATALYSIS; SUBSTITUTION REACTION;

EID: 4644255046     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.08.155     Document Type: Article

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58. 3) δ ppm: 12.5 (s, 1H), 8.36 (d, 1H, J = 2.5 Hz), 8.21 (d, 1H, J = 2.6 Hz), 8.02 (d, 2H, J = 7.2 Hz), 7.51 (t, 2H, J = 7.1 Hz), 7.42 (t, 1H, J = 7.2 Hz), 7.15 (d, 1H, J = 1.8 Hz)
59. The alkylnitrile (entry 3) gave a mixture of cyclized desulfonylated and cyclized sulfonylated material with the major product being the cyclized desulfonylated compound