γ-Hydroxybutyrate inhibits excitatory postsynaptic potentials in rat hippocampal slices

European Journal of Pharmacology

Volumn 380, Issue 2-3, 1999, Pages 109-116

  Berton, Fulvia ^a   Brancucci, Alfredo ^a   Beghè, Franco ^b   Cammalleri, Maurizio ^a   Demuro, Angelo ^a   Francesconi, Walter ^a   Gessa, Gianluigi ^c  

^a UNIVERSITY OF PISA   (Italy)

^b CT Pharmaceutical Laboratory   (Italy)

^c UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

AMPA kainate receptor; Excitatory postsynaptic potential; GABA(B) receptor; GHB ( hydroxybutyrate); Hippocampal slice; NCS 382; NMDA receptor; Paired pulse facilitation

Indexed keywords

3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 3 AMINOPROPYLBUTYLPHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 HYDROXYBUTYRIC ACID; AMPA RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NCS 382; UNCLASSIFIED DRUG;

ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DEPRESSION; DRUG MECHANISM; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; INHIBITORY POSTSYNAPTIC POTENTIAL; MALE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SYNAPTIC TRANSMISSION;

2-AMINO-5-PHOSPHONOVALERATE; ADJUVANTS, ANESTHESIA; ANIMALS; BENZOCYCLOHEPTENES; BICUCULLINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; GABA ANTAGONISTS; HIPPOCAMPUS; MALE; MEMBRANE POTENTIALS; NEURONS; ORGANOPHOSPHORUS COMPOUNDS; QUINOXALINES; RATS; RATS, WISTAR; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; SODIUM OXYBATE;

EID: 0032837890     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00515-4     Document Type: Article

References (44)

1. Addolorato G., Castelli E., Stefanini G.F. An open multicentric study evaluating 4-hydroxybutyric acid sodium salt in the medium-term treatment of 179 alcohol-dependent subjects. Alcohol Alcohol. 31:1996;341-345.
2. Addolorato G., Cibin M., Caprista E., Beghè F., Gessa G.L., Stefanini G.F., Gasbarrini G. Maintaining abstinence from alcohol with γ-hydroxybutyric acid. Lancet. 351:1998;38.
3. B) receptor-mediated release of GABA and glutamate (GLU) in rat thalamic ventrobasal nucleus (VB): a possible mechanism for the generation of absence-like seizures induced by GHB. J. Pharmacol. Exp. Ther. 273:1995;1534-1543.
4. +-dependent uptake system for γ-hydroxybutyrate in membrane vesicles prepared from rat brain. J. Neurochem. 38:1982;1570-1575.
5. Benavides J., Rumigny J.F., Burguignon J.J., Cash C., Wermuth C.G., Madel P., Vincendon G., Maitre M. High affinity binding sites for gamma-hydroxybutyric acid in rat brain. Life Sci. 30:1982;953-961.
6. Berretta N., Berton F., Bianchi R., Capogna M., Francesconi W., Brunelli M. Effects of dopamine, D-1 and D-2 dopaminergic agonists on the excitability of hippocampal CA1 pyramidal cells in guinea pig. Exp. Brain Res. 83:1990;124-130.
7. Colombo G., Agabio R., Lobina C., Reali R., Fadda F., Gessa G.L. Symmetrical generalization between the discriminative stimulus effects of gamma-hydroxybutyric acid and ethanol: occurrence within narrow dose ranges. Physiol. Behav. 57:1995;105-111.
8. Fadda F., Mosca G.L., Colombo G., Gessa G.L. Gamma-hydroxybutyric acid suppresses ethanol consumption in alcohol-preferring rats. Psychopharmacology. 96:1988;107.
9. Fadda F., Colombo G., Mosca E., Gessa G.L. Suppression by gamma-hydroxybutyric acid of ethanol withdrawal syndrome in rats. Alcohol Alcohol. 24:1989;447-451.
10. Gallimberti L., Canton G., Gentile N., Ferri M., Cibin M., Ferrara S.D., Fadda F., Gessa G.L. Gamma-hydroxybutyric acid for treatment of alcohol withdrawal syndrome. Lancet. 2:1989;787-789.
11. Gallimberti L., Ferri M., Ferrara S.D., Fadda F., Gessa G.L. Gamma-hydroxybutyric acid in the treatment of alcohol dependence: a double-blind study. Alcohol. Clin. Exp. Res. 16:1992;673-676.
12. Galloway G.P., Frederick S.L. Jr., Stagger F.E., Gonzales M., Stalcup, Smith D.E. Gamma-hydroxybutyrate: an emerging drug of abuse that causes physical dependence. Addiction. 92:1997;89-96.
13. Godbout R., Jelenic P., Labrie C. M., Schmitt M., Bourguignon J.J. Effect of gamma-hydroxybutyrate and its antagonist, NCS-382, on spontaneous cell firing in the prefrontal cortex of the rat. Brain Res. 673:1995;157-160.
14. Hechler V., Bourguignon J.J., Wermuth C.G., Madel P., Maitre M. γ-Hydroxybutyrate uptake by rat brain striatal slices. Neurochem. Res. 10:1985;387-396.
15. 3H )hydroxybutyrate binding sites as determined by quantitative autoradiography J. Neurochem. 49:1987;1025-1032.
16. Hechler V., Gobaille S., Bourguignon J.J., Maitre M. Extracellular events induced by γ-hydroxybutyrate in striatum: a microdialysis study. J. Neurochem. 56:1991;938-994.
17. Hechler V., Gobaille S., Maitre M. Selective distribution pattern of γ-hydroxybutyrate receptors in the rat forebrain and midbrain as revealed by quantitative autoradiography. Brain Res. 572:1992;345-348.
18. King M.A., Thinschmidt J.S., Walker D.W. Gamma-hydroxybutyrate (GHB) receptor ligand effects on evoked synaptic field potentials in CA1 of the rat hippocampal slice. J. Neural Transm. 104:1997;1177-1193.
19. Kozhechkin S.X. Microiontophoretic study of the mechanism of action of gamma-hydroxybutyric acid. Bull. Exp. Biol. Med. 88:1980;1293-1296.
20. Lettieri J.T., Fung H.L. Dose-dependent pharmacokinetics and hypnotic effects of sodium G-hydroxybutyrate in the rat. J. Pharmacol. Exp. Ther. 208:1979;7-11.
21. Lovinger D.M. High ethanol sensitivity of recombinant AMPA-type glutamate receptors expressed in mammalian cells. Neurosci. Lett. 159:1993;83-87.
22. Lovinger D.M., White G., Weight F.F. Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science. 243:1989;1721-1724.
23. Lovinger D.M., White G., Weight F.F. NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat. J. Neurosci. 10:1990;1372-1379.
24. Maitre M. The γ-hydroxybutyrate signaling system in brain: organization and functional implications. Prog. Neurobiol. 51:1997;337-361.
25. Maitre M., Mandel P. Libération de γ-hydroxybutyrate calcium-dépendante après dépolarisation de coupes de cerveau de rat. C. R. Acad. Sci. Paris. 295:1982;741-743.
26. Maitre M., Cash C., Weissmann-Nanopoulos D., Madel P. Depolarization-evoked release of γ-hydroxybutyrate from rat brain slices. J. Neurochem. 41:1983;287-290.
27. Maitre M., Rumigny J.F., Cash C., Mandel P. Subcellular distribution of γ-hydroxybutyrate binding sites in rat brain. Principal location in the synaptosomal fraction. Biochem. Biophys. Res. Commun. 110:1983;262-265.
28. Maitre M., Hechler V., Vayer P., Gobaille S., Cash C.D., Schmitt M., Bourguignon J.J. A specific γ-hydroxybutyrate receptor ligand possesses both antagonistic and anticonvulsant properties. J. Pharmacol. Exp. Ther. 255:1990;657-663.
29. Manabe T., Wyllie D.J.A., Perkel D.J., Nicoll R.A. Modulation of synaptic transmission and long-term potentiation: effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus. J. Neurophysiol. 70:1993;1451-1459.
30. Nie Z., Yuan X., Madamba S.G., Siggins G.R. Ethanol decreases glutamatergic synaptic transmission in rat nucleus accumbens in vitro: naloxone reversal. J. Pharmacol. Exp. Ther. 266:1993;1705-1712.
31. Nie Z., Madamba S.G., Siggins G.R. Ethanol inhibits glutamatergic neurotransmission in nucleus accumbens neurons by multiple mechanisms. J. Pharmacol. Exp. Ther. 271:1994;1566-1573.
32. Olpe H.R., Koella W.P. Inhibition of nigral and neocortical cells by γ-hydroxybutyrate: a microiontophoretic investigation. Eur. J. Pharmacol. 53:1979;359-364.
33. Ratomponirina C., Hodè Y., Hechler V., Maitre M. γ-Hydroxybutyrate receptor binding in rat brain is inhibited by guanyl nucleotides and pertussis toxin. Neurosci. Lett. 189:1995;51-53.
34. Roth R.H., Giarman J. Natural occurrence of gamma-hydroxybutyrate in mammalian brain. Biochem. Pharmacol. 19:1970;1087-1093.
35. Snead O.C. γ-Hydroxybutyric acid in subcellular fractions of rat brain. J. Neurochem. 48:1987;196-201.
36. Tsai G., Gastfriend D.R., Coyle J.T. The glutamatergic basis of human alcoholism. Am. J. Psychiatry. 152:1995;332-340.
37. Tunnicliff G. Sites of action of gamma-hydroxybutyrate (GHB) - a neuroactive drug with abuse potential. J. Toxicol. Clin. Toxicol. 35:1997;581-590.
38. Vayer P., Maitre M. γ-Hydroxybutyrate stimulation of the formation of cyclic GMP and inositol phosphates in rat hippocampal slice. J. Neurochem. 52:1989;1382-1387.
39. Vayer P., Mandel J.T., Maitre M. Gamma-hydroxybutyrate, a possible neurotransmitter. Life Sci. 41:1987;1547-1557.
40. Vayer P., Gobaille S., Mandel P., Maitre M. 3′-5′-Cyclic-guanosine monophosphate increase in rat brain hippocampus after gamma-hydroxybutyrate administration. Prevention by valproate and naloxone. Life Sci. 41:1987;605-610.
41. Weight F.F., Lovinger D.M., White G. Alcohol inhibition of NMDA channel function. Alcohol Alcohol. 1:1991;163-169.
42. B receptor-mediated hyperpolarization. Neuroscience. 66:1995;133-141.
43. B receptors. Eur. J. Pharmacol. 212:1992;291-294.
44. Xie X., Smart T.G. γ-Hydroxybutyrate depresses monosynaptic excitatory and inhibitory postsynaptic potentials in rat hippocampal slices. Eur. J. Pharmacol. 223:1992;193-196.