Mismatch repair deficiency does not enhance ENU mutagenesis in the zebrafish germ line

Mutagenesis

Volumn 23, Issue 4, 2008, Pages 325-329

  Feitsma, Harma ^a   De Bruijn, Ewart ^a   Van De Belt, Jose ^a   Nijman, Isaac J ^a   Cuppen, Edwin ^a  

^a HUBRECHT INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; ETHYLNITROSOUREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; GENE SEQUENCE; GENE TARGETING; GERM LINE; MISMATCH REPAIR; MUTAGENESIS; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; ZEBRA FISH;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; DNA MISMATCH REPAIR; DNA REPAIR-DEFICIENCY DISORDERS; DNA-BINDING PROTEINS; EMBRYO, NONMAMMALIAN; ETHYLNITROSOUREA; FERTILIZATION; GENE FREQUENCY; GERM CELLS; GERM-LINE MUTATION; MALE; MUTAGENESIS; MUTAGENS; ZEBRAFISH;

DANIO RERIO;

EID: 46349091165     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/gen019     Document Type: Article

References (30)

1. Haffter, P., Granato, M., Brand, M. et al. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development, 123, 1-36.
2. Mullins, M. C., Hammerschmidt, M., Haffter, P. and Nusslein-Volhard, C. (1994) Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate. Curr Biol., 4, 189-202.
3. Solnica-Krezel, L., Schier, A. F. and Driever, W. (1994) Efficient recovery of ENU-induced mutations from the zebrafish germline. Genetics, 136, 1401-1420.
4. Knapik, E. W. (2000) ENU mutagenesis in zebrafish-from genes to complex diseases. Mamm. Genome, 11, 511-519.
5. Smits, B. M., Mudde, J., Plasterk, R. H. and Cuppen, E. (2004) Target-selected mutagenesis of the rat. Genomics, 83, 332-334.
6. Smits, B. M., Mudde, J. B., van de Belt, J. et al. (2006) Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis. Pharmacogenet. Genomics, 16, 159-169.
7. Wienholds, E. and Plasterk, R. H. (2004) Target-selected gene inactivation in zebrafish. Methods Cell Biol., 77, 69-90.
8. Wienholds, E., van Eeden, F., Kosters, M., Mudde, J., Plasterk, R. H. and Cuppen, E. (2003) Efficient target-selected mutagenesis in zebrafish. Genome Res., 13, 2700-2707.
9. Noveroske, J. K., Weber, J. S. and Justice, M. J. (2000) The mutagenic action of N-ethyl-N-nitrosourea in the mouse. Mamm. Genome, 11, 478-483.
10. Wyatt, M. D. and Pittman, D. L. (2006) Methylating agents and DNA repair responses: methylated bases and sources of strand breaks. Chem. Res. Toxicol., 19, 1580-1594.
11. Zak, P., Kleibl, K. and Laval, F. (1994) Repair of O6-methylguanine and O4-methylthymine by the human and rat O6-methylguanine-DNA methyltransferases. J. Biol. Chem., 269, 730-733.
12. Kaina, B., Fritz, G. and Coquerelle, T. (1993) Contribution of O6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: new insights gained from studies of genetically engineered mammalian cell lines. Environ. Mol. Mutagen., 22, 283-292.
13. Hickman, M. J. and Samson, L. D. (1999) Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents. Proc. Natl Acad. Sci. USA, 96, 10764-10769.
14. Bignami, M., O'Driscoll, M., Aquilina, G. and Karran, P. (2000) Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents. Mutat. Res., 462, 71-82.
15. O'Brien, V. and Brown, R. (2006) Signalling cell cycle arrest and cell death through the MMR System. Carcinogenesis, 27, 682-692.
16. Stojic, L., Brun, R. and Jiricny, J. (2004) Mismatch repair and DNA damage signalling. DNA Repair (Amst.), 3, 1091-1101.
17. Nowosielska, A. and Marinus, M. G. (2008) DNA mismatch repair-induced double-strand breaks. DNA Repair (Amst.), 7, 48-56.
18. Stojic, L., Mojas, N., Cejka, P., Di Pietro, M., Ferrari, S., Marra, G. and Jiricny, J. (2004) Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase. Genes Dev., 18, 1331-1344.
19. Borgdorff, V., van Hees-Stuivenberg, S., Meijers, C. M. and de Wind, N. (2005) Spontaneous and mutagen-induced loss of DNA mismatch repair in Msh2-heterozygous mammalian cells. Mutat. Res., 574, 50-57.
20. Claij, N., van der Wal, A., Dekker, M., Jansen, L. and te Riele, H. (2003) DNA mismatch repair deficiency stimulates N-ethyl-N-nitrosourea-induced mutagenesis and lymphomagenesis. Cancer Res., 63, 2062-2066.
21. Zhang, H., Marra, G., Jiricny, J., Maher, V. M. and McCormick, J. J. (2000) Mismatch repair is required for O(6)-methylguanine-induced homologous recombination in human fibroblasts. Carcinogenesis, 21, 1639-1646.
22. Armstrong, M. J. and Galloway, S. M. (1997) Mismatch repair provokes chromosome aberrations in hamster cells treated with methylating agents or 6-thioguanine, but not with ethylating agents. Mutat. Res., 373, 167-178.
23. Galloway, S. M., Greenwood, S. K., Hill, R. B., Bradt, C. I. and Bean, C. L. (1995) A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells. Mutat. Res., 346, 231-245.
24. Denver, D. R., Feinberg, S., Estes, S., Thomas, W. K. and Lynch, M. (2005) Mutation rates, spectra and hotspots in mismatch repair-deficient Caenorhabditis elegans. Genetics, 170, 107-113.
25. Walker, C. and Streisinger, G. (1983) Induction of mutations by gamma-rays in pregonial germ cells of zebrafish embryos. Genetics, 103, 125-136.
26. Favor, J. (1999) Mechanisms of mutation induction in germ cells of the mouse as assessed by the specific locus test. Mutat. Res., 428, 227-236.
27. Jansen, J. G., Vrieling, H., van Teijlingen, C. M., Mohn, G. R., Tates, A. D. and van Zeeland, A. A. (1995) Marked differences in the role of O6-alkylguanine in hprt mutagenesis in T-lymphocytes of rats exposed in vivo to ethylmethanesulfonate, N-(2-hydroxyethyl)-N-nitrosourea, or N-ethyl-N- nitrosourea. Cancer Res., 55, 1875-1882.
28. Takahasi, K. R., Sakuraba, Y. and Gondo, Y. (2007) Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis. BMC Mol. Biol., 8, 52.
29. Cuppen, E., Gort, E., Hazendonk, E., Mudde, J., van de Belt, J., Nijman, I. J., Guryev, V. and Plasterk, R. H. (2007) Efficient target-selected mutagenesis in Caenorhabditis elegans: toward a knockout for every gene. Genome Res., 17, 649-658.
30. Feitsma, H., Leal, M. C., Moens, P. B., Cuppen, E. and Schulz, R. W. (2007) Mlh1 deficiency in zebrafish results in male sterility and aneuploid as well as triploid progeny in females. Genetics, 175, 1561-1569.