Inhibition of vascular endothelial growth factor in the primate ovary up-regulates hypoxia-inducible factor-1α in the follicle and corpus luteum

Endocrinology

Volumn 149, Issue 7, 2008, Pages 3313-3320

  Duncan, W Colin ^a,c   Van Den Driesche, Sander ^a   Fraser, Hamish M ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MATURATION; CONTROLLED STUDY; CORPUS LUTEUM; FEMALE; FIRST TRIMESTER PREGNANCY; GRANULOSA CELL; HORMONAL REGULATION; IMMUNOHISTOCHEMISTRY; LUTEAL PHASE; NONHUMAN; OVARY CYCLE; OVARY FOLLICLE; PRIMATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; UPREGULATION;

ANIMALS; CALLITHRIX; CORPUS LUTEUM; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; OVARIAN FOLLICLE; OVARY; RECOMBINANT FUSION PROTEINS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 46349086078     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-1649     Document Type: Article

References (34)

1. Redmer DA, Reynolds LP 1996 Angiogenesis in the ovary. Rev Reprod 1: 182-192
2. Fraser HM, Duncan WC 2005 Vascular morphogenesis in the primate ovary. Angiogenesis 8:101-116
3. Fraser HM, Dickson SE, Lunn SF, Wulff C, Morris KD, Carroll VA, Bicknell R 2000 Suppression of luteal angiogenesis in the primate after neutralization of vascular endothelial growth factor. Endocrinology 141:995-1000
4. Fraser HM, Wilson H, Morris KD, Swanston I, Wiegand SJ 2005 Vascular endothelial growth factor Trap suppresses ovarian function at all stages of the luteal phase in the macaque. J Clin Endocrinol Metab 90:5811-5818
5. Fraser HM, Wilson H, Wulff C, Rudge JS, Wiegand SJ 2006 Administration of vascular endothelial growth factor Trap during the 'post-angiogenic' period of the luteal phase causes rapid functional luteolysis and selective endothelial cell death in the marmoset. Reproduction 132:589-600
6. Wulff C, Wilson H, Wiegand SJ, Rudge JS, Fraser HM 2002 Prevention of thecal angiogenesis, antral follicular growth, and ovulation in the primate by treatment with vascular endothelial growth factor Trap R1R2. Endocrinology 143:2797-2807
7. Taylor PD, Hillier SG, Fraser HM 2004 Effects of GnRH antagonist treatment on follicular development and angiogenesis in the primate ovary. J Endocrinol 183:1-17
8. Fraser HM, Lunn SF, Harrison DJ, Kerr JB 1999 Luteal regression in the primate: different forms of cell death during natural and gonadotropin-releasing hormone antagonist or prostaglandin analogue-induced luteolysis. Biol Reprod 61:1468-1479
9. Fraser HM, Bell J, Wilson H, Taylor PD, Morgan K, Anderson RA, Duncan WC 2005 Localization and quantification of cyclic changes in the expression of endocrine gland vascular endothelial growth factor in the human corpus luteum. J Clin Endocrinol Metab 90:427-434
10. Neulen J, Yan Z, Raczek S, Weindel K, Keck C, Weich HA, Marme D, Breckwoldt M 1995 Human chorionic gonadotropin-dependent expression of vascular endothelial growth factor/vascular permeability factor in human granulosa cells: importance in ovarian hyperstimulation syndrome. J Clin Endocrinol Metab 80:1967-1971
11. Hazzard TM, Molskness TA, Chaffin CL, Stouffer RL 1999 Vascular endothelial growth factor (VEGF) and angiopoietin regulation by gonadotrophin and steroids in macaque granulosa cells during the peri-ovulatory interval. Mol Hum Reprod 5:1115-1121
12. Wulff C, Wilson H, Largue P, Duncan WC, Armstrong DG, Fraser HM 2000 Angiogenesis in the human corpus luteum: localization and changes in angiopoietins, tie-2, and vascular endothelial growth factor messenger ribonucleic acid. J Clin Endocrinol Metab 85:4302-4309
13. Ferrara N 2004 Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 25:581-611
14. Tesone M, Stouffer RL, Borman SM, Hennebold JD, Molskness TA 2005 Vascular endothelial growth factor (VEGF) production by the monkey corpus luteum during the menstrual cycle: isoform-selective messenger RNA expression in vivo and hypoxia-regulated protein secretion in vitro. Biol Reprod 73:927-934
15. Tropea A, Miceli F, Minici F, Tiberi F, Orlando M, Gangale MF, Romani F, Catino S, Mancuso S, Navarra P, Lanzone A, Apa R 2006 Regulation of vascular endothelial growth factor synthesis and release by human luteal cells in vitro. J Clin Endocrinol Metab 91:2303-2309
16. Critchley HO, Osei J, Henderson TA, Boswell L, Sales KJ, Jabbour HN, Hirani N 2006 Hypoxia-inducible factor-1α expression in human endometrium and its regulation by prostaglandin E-series prostanoid receptor 2 (EP2). Endocrinology 147:744-753
17. Semenza GL 2000 Expression of hypoxia-inducible factor 1: mechanisms and consequences. Biochem Pharmacol 59:47-53
18. Summers PM, Wennink CJ, Hodges JK 1985 Cloprostenol-induced luteolysis in the marmoset monkey (Callithrix jacchus). J Reprod Fertil 73:133-138
19. Holash J, Davis S, Papadopoulos N, Croll SD, Ho L, Russell M, Boland P, Leidich R, Hylton D, Burova E, Ioffe E, Huang T, Radziejewski C, Bailey K, Fandl JP, Daly T, Wiegand SJ, Yancopoulos GD, Rudge JS 2002 VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 99:11393-11398
20. Taylor PD, Wilson H, Hillier SG, Wiegand SJ, Fraser HM 2007 Effects of inhibition of vascular endothelial growth factor at time of selection on follicular angiogenesis, expansion, development and atresia in the marmoset. Mol Hum Reprod 13:729-736
21. Thomas FH, Telfer EE, Fraser HM 2007 Expression of anti-Mullerian hormone protein during early follicular development in the primate ovary in vivo is influenced by suppression of gonadotropin secretion and inhibition of vascular endothelial growth factor. Endocrinology 148:2273-2281
22. Harlow CR, Hearn JP, Hodges JK 1984 Ovulation in the marmoset monkey: endocrinology, prediction and detection. J Endocrinol 103:17-24
23. Rowe AJ, Morris KD, Bicknell R, Fraser HM 2002 Angiogenesis in the corpus luteum of early pregnancy in the marmoset and the effects of vascular endothelial growth factor immunoneutralization on establishment of pregnancy. Biol Reprod 67:1180-1188
24. Duncan WC, Rodger FE, Illingworth PJ 1998 The human corpus luteum: reduction in macrophages during simulated maternal recognition of pregnancy. Hum Reprod 13:2435-2442
25. Duncan WC, Illingworth PJ, Fraser HM 1996 Expression of tissue inhibitor of metalloproteinases-1 in the primate ovary during induced luteal regression. J Endocrinol 151:203-213
26. Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, Semenza GL 1996 Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16:4604-4613
27. Monsef N, Helczynski L, Lundwall A, Pahlman S 2007 Localization of immunoreactive HIF-1α and HIF-2α in neuroendocrine cells of both benign and malignant prostate glands. Prostate 67:1219-1229
28. Wulff C, Wilson H, Rudge JS, Wiegand SJ, Lunn SF, Fraser HM 2001 Luteal angiogenesis: prevention and intervention by treatment with vascular endothelial growth factor trap(A40). J Clin Endocrinol Metab 86:3377-3386
29. Boonyaprakob U, Gadsby JE, Hedgpeth V, Routh PA, Almond GW 2005 Expression and localization of hypoxia inducible factor-1α mRNA in the porcine ovary. Can J Vet Res 69:215-222
30. Bilton RL, Booker GW 2003 The subtle side to hypoxia inducible factor (HIFα) regulation. Eur J Biochem 270:791-798
31. Airley RE, Mobasheri A 2007 Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: novel pathways and targets for anticancer therapeutics. Chemotherapy 53:233-256
32. Alam H, Maizels ET, Park Y, Ghaey S, Feiger ZJ, Chandel NS, Hunzicker-Dunn M 2004 Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation. J Biol Chem 279:19431-19440
33. Herr D, Keck C, Tempfer C, Pietrowski D 2004 Chorionic gonadotropin regulates the transcript level of VHL, p53, and HIF-2α in human granulosa lutein cells. Mol Reprod Dev 69:397-401
34. Wulff C, Dickson SE, Duncan WC, Fraser HM 2001 Angiogenesis in the human corpus luteum: simulated early pregnancy by HCG treatment is associated with both angiogenesis and vessel stabilization. Hum Reprod 16:2515-2524