Vascular endothelial growth factor trap suppresses ovarian function at all stages of the luteal phase in the macaque

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 10, 2005, Pages 5811-5818

  Fraser, Hamish M ^a,c   Wilson, Helen ^a   Morris, Keith D ^a   Swanston, Ian ^a   Wiegand, Stanley J ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b REGENERON PHARMACEUTICALS INC   (United States)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; FOLLITROPIN; INHIBIN A; LUTEINIZING HORMONE; PROGESTERONE; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; FEMALE; LUTEAL PHASE; MENSTRUATION; MONKEY; NONHUMAN; OVARY FUNCTION; OVULATION; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL;

ANIMALS; ANTIBODIES, BLOCKING; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; FEMALE; GONADAL STEROID HORMONES; IMMUNOGLOBULIN FC FRAGMENTS; INHIBINS; LUTEAL PHASE; MACACA; NEOVASCULARIZATION, PHYSIOLOGIC; OVARY; OVULATION; PROGESTERONE; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

MACACA ARCTOIDES; PRIMATES;

EID: 26244455109     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-1199     Document Type: Article

References (38)

1. Augustin HG 2000 Development of the vascular system of the corpus luteum. In: Risau W, ed. Morphogenesis of endothelium. Reading, UK: Harwood Academic Publishers; 237-254
2. Hazzard TM, Stouffer RL 2000 Angiogenesis in ovarian follicular and luteal development. Baillieres Best Pract Res Clin Obstet Gynaecol 14:883-900
3. Fraser HM, Wulff C 2003 Angiogenesis in the corpus luteum. Reprod Biol Endocrinol 1:88
4. Christenson LK, Stouffer RL 1996 Proliferation of microvascular endothelial cells in the primate corpus luteum during the menstrual cycle and simulated early pregnancy. Endocrinology 137:367-374
5. Dickson SE, Fraser HM 2000 Inhibition of early luteal angiogenesis by gonadotropin-releasing hormone antagonist treatment in the primate. J Clin Endocrinol Metab 85:2339-2344
6. Hazzard TM, Christenson LK, Stouffer RL 2000 Changes in expression of vascular endothelial growth factor and angiopoietin-1 and -2 in the macaque corpus luteum during the menstrual cycle. Mol Hum Reprod 6:993-998
7. Wulff C, Wilson H, Largue P, Duncan WC, Armstrong D, Fraser HM 2000 Angiogenesis in the human corpus luteum: localization and changes in angiopoietins, Tie-2 and vascular endothelial growth factor messenger ribonucleic acid. J Clin Endocrinol Metab 85:4302-4309
8. Fraser HM, Bell J, Wilson H, Taylor PD, Morgan K, Anderson RA, Duncan WC 2005 Localisation and quantification of cyclic changes in expression of endocrine gland vascular endothelial growth factor in the human corpus luteum. J Clin Endocrinol Metab 90:427-434
9. Ferrara N, Chen H, Davis-Smyth T, Geber H-P, Nguyen T-N, Peers D, Chisholm V, Hillan KJ, Schwall RH 1998 Vascular endothelial growth factor is essential for corpus luteum angiogenesis. Nat Med 4:336-340
10. Hazzard TM, Xu F, Stouffer RL 2002 Injection of soluble vascular endothelial growth factor receptor 1 into the preovulatory follicle disrupts ovulation and subsequent luteal function in rhesus monkeys. Biol Reprod 67:1305-1312
11. Zimmermann RC, Xiao E, Bohlen P, Ferin M 2002 Administration of antivascular endothelial growth factor receptor 2 antibody in the early follicular phase delays follicular selection and development in the rhesus monkey. Endocrinology 143:2496-2502
12. Fraser H, Wilson H, Rudge J, Wiegand SJ 2005 Single injections of vascular endothelial growth factor trap block ovulation in the macaque and produce a prolonged, dose-related suppression of ovarian function. J Clin Endocrinol Metab 90:1114-1122
13. Fraser HM, Dickson SE, Lunn SF, Wulff C, Morris KD, Carroll V, Bicknell R 2000 Suppression of luteal angiogenesis in the primate after neutralization of vascular endothelial growth factor. Endocrinology 141:995-1000
14. Wulff C, Wilson H, Rudge JS, Wiegand SJ, Lunn SF, Fraser HM 2001 Luteal angiogenesis: prevention and intervention by treatment with vascular endothelial growth factor trap A40. J Clin Endocrinol Metab 86:3377-3386
15. Fraser HM, Nestor Jr JJ, Vickery BH 1987 Suppression of luteal function by a luteinizing hormone-releasing hormone antagonist during the early luteal phase in the stump-tailed macaque monkey and the effects of subsequent administration of human chorionic gonadotropin. Endocrinology 121:612-618
16. Dubourdieu S, Charbonnel B, Massai M, Marraoul J, Spitz I, Bouchard P 1991 Suppression of corpus luteum function by the gonadotropin releasing hormone antagonist Nal Glu: effect of the dose and timing of human chorionic gonadotropin administration. Fertil Steril 56:440-445
17. Fraser HM, Groome NP, McNeilly AS 1999 Follicle stimulating hormoneinhibin B interactions during the follicular phase of the primate menstrual cycle revealed by GnRH antagonist and anti-estrogen treatment. J Clin Endocrinol Metab 84:1365-1369
18. Holash J, Davis S, Papadopoulos N, Croll SD, Ho L, Russell M, Boland P, Leidich R, Hylton D, Burova E, Ioffe E, Huang T, Radziejewski C, Bailey K, Fandl JP, Daly T, Wiegand SJ, Yancopoulos GD, Rudge JS 2002 VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 99:11393-11398
19. Fraser HM, Sandow J 1985 Suppression of follicular maturation by infusion of a luteinizing hormone-releasing hormone agonist starting during the late luteal phase in the stump-tailed macaque monkey. J Clin Endocrinol Metab 60:579-584
20. Hodgen GD 1982 The dominant follicle. Fertil Steril 38:281-300
21. Maruncic M, Casper RF 1987 The effect of luteal phase estrogen antagonism on luteinizing hormone pulsatility and luteal function in women. J Clin Endocrinol Metab 64:148-152
22. Groome NP, Illingworth PJ, O'Brien M, Cooke I, Ganesan TS, Baird DT, McNeilly AS 1994 Detection of dimeric inhibin throughout the human menstrual cycle by two-site enzyme immunoassay. Clin Endocrinol (Oxf) 40:717-723
23. Fraser HM, Lunn SF 1993 Does inhibin have an endocrine function during the menstrual cycle? Trends Endocrinol Metab 4:187-194
24. Stouffer RL, Dahl KD, Hess DL, Woodruff TK, Mather JP, Molskness TA 1994 Systemic and intraluteal infusion of inhibin-A or activin-A in rhesus monkeys during the luteal phase of the menstrual cycle. Biol Reprod 50:888-895
25. Hayes FJ, Hall JE, Boepple PA, Crowley WFJ 1998 Differential control of gonadotropin secretion in the human: endocrine role of inhibin. J Clin Endocrinol Metab 83:1835-1841
26. Zeleznik AJ, Hutchison JS, Schuler HM 1987 Passive immunization with anti-oestradiol antibodies during the luteal phase of the menstrual cycle potentiates the perimenstrual rise in serum gonadotrophin concentrations and stimulates follicular growth in the cynomolgus monkey (Macaca fascicularis). J Reprod Fertil 80:403-410
27. Le Nestour E, Marraoui J, Lahlou N, Roger M, de Ziegler D, Bouchard P 1993 Role of estradiol in the rise in follicle-stimulating hormone levels during the luteal-follicular transition. J Clin Endocrinol Metab 77:439-442
28. Welt CK, Pagan YL, Smith PC, Rado KB, Hall JE 2003 Control of follicle-stimulating hormone by estradiol and the inhibins: critical role of estradiol at the hypothalamus during the luteal-follicular transition. J Clin Endocrinol Metab 88:1766-1771
29. Groome NP, Illingworth PJ, O'Brien M, Pai R, Rodger FE, Mather JP, McNeilly AS 1996 Measurement of dimeric inhibin B throughout the human menstrual cycle. J Clin Endocrinol Metab 81:1401-1405
30. Fraser HM, Lunn SF, Cowen GM, Saunders PTK 1993 Localization of inhibin/activin subunit mRNAs during the luteal phase in the primate ovary. J Mol Endocrinol 10:245-257
31. Roberts VJ, Barth S, El-Roeiy A, Yen SSC 1993 Expression of inhibin/activin subunits and follistatin messenger ribonucleic acids and proteins in ovarian follicles and the corpus luteum during the human menstrual cycle. J Clin Endocrinol Metab 77:1402-1410
32. Dickson SE, Bicknell R, Fraser HM 2001 Mid-luteal angiogenesis and function in the primate is dependent on vascular endothelial growth factor. J Endocrinol 168:409-416
33. Pauli SA, Tang HY, Wang J, Bohlen P, Posser R, Hartman T, Sauer MV, Kitajewski J, Zimmermann RC 2005 The vascular endothelial growth factor VEGF/VERF receptor 2 pathway is critical for blood vessel survival in corpora luteal of pregnancy in the rodent. Endocrinology 148:1301-1311
34. Rabbani ML, Rogers PA 2001 Role of vascular endothelial growth factor in endometrial vascular events before implantation in rats. Reproduction 122:85-90
35. Rockwell LC, Pillai S, Olson CE, Koos RD 2002 Inhibition of vascular endothelial growth factor/vascular permeability factor action blocks estrogen-induced uterine edema and implantation in rodents. Biol Reprod 67:1804-1810
36. Rowe AJ, Morris KD, Bicknell R, Fraser HM 2002 Angiogenesis in the corpus luteum of early pregnancy in the marmoset and the effects of vascular endothelial growth factor immunoneutralization on establishment of pregnancy. Biol Reprod 67:1180-1188
37. Fraser HM, Lunn SF 2000 Angiogenesis and its control in the female reproductive system. Br Med Bull 56:787-797
38. Zimmermann RC, Xiao E, Husami N, Sauer MV, Lobo R, Kitajewski J, Ferin M 2001 Short-term administration of antivascular endothelial growth factor antibody in the late follicular phase delays follicular development in the rhesus monkey. J Clin Endocrinol Metab 86:768-772