Alterations in the immunohistochemical eof das-1 and CG-3 in colonic mucosal biopsy specimens helps distinguish ulcerative colitis from crohn disease and from other forms of colitis

American Journal of Surgical Pathology

Volumn 32, Issue 6, 2008, Pages 844-850

  Yantiss, Rhonda K ^a   Das, Kiron M ^b   Farraye, Francis A ^c   Odze, Robert D ^d  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Autoantibodies; Immunohistochemistry; In?ammatory bowel disease; Tropomyosin

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CG 3; MONOCLONAL ANTIBODY DAS 1; UNCLASSIFIED DRUG; ANTIBODY; DAS 1 PROTEIN, HUMAN; DAS-1 PROTEIN, HUMAN; DIAGNOSTIC AGENT; TPM3 PROTEIN, HUMAN; TROPOMYOSIN;

ADULT; AGED; ARTICLE; CLINICAL FEATURE; COLLAGENOUS COLITIS; COLON BIOPSY; COLON CROHN DISEASE; CONTROLLED STUDY; DISEASE CLASSIFICATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ISCHEMIC COLITIS; LYMPHOCYTIC COLITIS; MAJOR CLINICAL STUDY; MALE; ULCERATIVE COLITIS; ADOLESCENT; COLITIS; COLON; CROHN DISEASE; IMMUNOLOGY; INTESTINE MUCOSA; METABOLISM; MIDDLE AGED; PATHOLOGY; RETROSPECTIVE STUDY;

ADOLESCENT; ADULT; AGED; ANTIBODIES; ANTIBODIES, MONOCLONAL; COLITIS; COLITIS, ULCERATIVE; COLON; CROHN DISEASE; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; TROPOMYOSIN;

EID: 46249118138     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e31815b121c     Document Type: Article

References (40)

1. Biancone L, Mandal A, Yang H, et al. Production of immunoglo-bulin G and G1 antibodies to cytoskeletal protein by lamina propria cells in ulcerative colitis. Gastroenterology. 1995;109:3-12.
2. Burnham WR, Ansell ID, Langman MJ. Normal sigmoidoscopic findings in severe ulcerative colitis: an important and common occurrence. Gut. 1980;21:A460.
3. D'Haens G, Geboes K, Peeters M, et al. Patchy cecal inflammation associated with distal ulcerative colitis: a prospective endoscopic study. Am J Gastroenterol. 1997;92:1275-1279.
4. Das KM, Sakamaki S, Vecchi M, et al. The production and characterization of monoclonal antibodies to a human colonic antigen associated with ulcerative colitis: cellular localization of the antigen by using the monoclonal antibody. J Immunol. 1987;139: 77-84.
5. Das KM, Sakamaki S, Vecchi M. Ulcerative colitis: specific antibodies against a colonic epithelial Mr 40,000 protein. Immunol Invest. 1989;18:459-472.
6. Das KM, Vecchi M, Sakamaki S. A shared and unique epitope(s) on human colon, skin, and biliary epithelium detected by a monoclonal antibody. Gastroenterology. 1990;98:464-469.
7. Das KM, Dasgupta A, Mandal A, et al. Autoimmunity to cytoskeletal protein tropomyosin. A clue to the pathogenetic mechanism for ulcerative colitis. J Immunol. 1993;150:2487-2493.
8. Das KM, Prasad I, Garla S, et al. Detection of a shared colon epithelial epitope on Barrett epithelium by a novel monoclonal antibody. Ann Intern Med. 1994;120:753-756.
9. DeMeester SR, Wickramasinghe KS, Lord RV, et al. Cytokeratin and DAS-1 immunostaining reveal similarities among cardiac mucosa, CIM, and Barrett's esophagus. Am J Gastroenterol. 2002; 97:2514-2523.
10. Ebert EC, Geng X, Lin J, et al. Autoantibodies against human tropomyosin isoform 5 in ulcerative colitis destroys colonic epithelial cells through antibody and complement-mediated lysis. Cell Immunol. 2006;244:43-49.
11. Farmer M, Petras RE, Hunt LE, et al. The importance of diagnostic accuracy in colonic inflammatory bowel disease. Am J Gastroenterol. 2000;95:3184-3188.
12. Geng X, Biancone L, Dai HH, et al. Tropomyosin isoforms in intestinal mucosa: production of autoantibodies to tropomyosin isoforms in ulcerative colitis. Gastroenterology. 1998;114:912-922.
13. Glickman JN, Wang H, Das KM, et al. Phenotype of Barrett's esophagus and intestinal metaplasia of the distal esophagus and gastroesophageal junction: an immunohistochemical study of cytokeratins 7 and 20, Das-1 and 45 MI. Am J Surg Pathol. 2001; 25:87-94.
14. Glickman JN, Bousvaros A, Farraye FA, et al. Pediatric patients with untreated ulcerative colitis may present initially with unusual morphologic findings. Am J Surg Pathol. 2004;28:190-197.
15. Goldstein N, Dulai M. Contemporary morphologic definition of backwash ileitis in ulcerative colitis and features that distinguish it from Crohn disease. Am J Clin Pathol. 2006;126:1-12.
16. Griffel LH, Amenta PS, Das KM. Use of a novel monoclonal antibody in diagnosis of Barrett's esophagus. Dig Dis Sci. 2000;45:40-48.
17. Groisman GM, George J, Harpaz N. Ulcerative appendicitis in universal and nonuniversal ulcerative colitis. Mod Pathol. 1994;7: 322-325.
18. Guy TS, Williams NN, Rosato EF. Crohn's disease of the colon. Surg Clin North Am. 2001;81:159-168, ix.
19. Halstensen TS, Das KM, Brandtzaeg P. Epithelial deposits of immunoglobulin G1 and activated complement colocalise with the M(r) 40kD putative autoantigen in ulcerative colitis. Gut. 1993;34: 650-657.
20. Harpaz N, Friedman S, George J. Superficial Crohn's colitis: pathological and clinical features including long-term follow-up. Mod Pathol. 2001;14:86A.
21. Haskell H, Andrews CW Jr, Reddy SI, et al. Pathologic features and clinical significance of "backwash" ileitis in ulcerative colitis. Am J Surg Pathol. 2005;29:1472-1481.
22. Heresbach D, Alexandre JL, Branger B, et al. Frequency and significance of granulomas in a cohort of incident cases of Crohn's disease. Gut. 2005;54:215-222.
23. Kesari KV, Yoshizaki N, Geng X, et al. Externalization of tropomyosin isoform 5 in colon epithelial cells. Clin Exp Immunol. 1999;118:219-227.
24. Lazenby AJ. Collagenous and lymphocytic colitis. Semin Diagn Pathol. 2005;22:295-300.
25. Mahadeva U, Martin JP, Patel NK, et al. Granulomatous ulcerative colitis: a re-appraisal of the mucosal granuloma in the distinction of Crohn's disease from ulcerative colitis. Histopathology. 2002;41: 50-55.
26. Mirza ZK, Das KK, Slate J, et al. Gastric intestinal metaplasia as detected by a monoclonal antibody is highly associated with gastric adenocarcinoma. Gut. 2003;52:807-812.
27. Mirza ZK, Sastri B, Lin JJ, et al. Autoimmunity against human tropomyosin isoforms in ulcerative colitis: localization of specific human tropomyosin isoforms in the intestine and extraintestinal organs. Inflamm Bowel Dis. 2006;12:1036-1043.
28. Odze R, Antonioli D, Peppercorn M, et al. Effect of topical 5-aminosalicylic acid (5-ASA) therapy on rectal mucosal biopsy morphology in chronic ulcerative colitis. Am J Surg Pathol. 1993;17: 869-875.
29. Onuma EK, Amenta PS, Ramaswamy K, et al. Autoimmunity in ulcerative colitis (UC): a predominant colonic mucosal B cell response against human tropomyosin isoform 5. Clin Exp Immunol. 2000;121:466-471.
30. Onuma EK, Amenta PS, Jukkola AF, et al. A phenotypic change of small intestinal epithelium to colonocytes in small intestinal adenomas and adenocarcinomas. Am J Gastroenterol. 2001;96: 2480-2485.
31. Rajwal SR, Puntis JW, McClean P, et al. Endoscopic rectal sparing in children with untreated ulcerative colitis. J Pediatr Gastroenterol Nutr. 2004;38:66-69.
32. Rogge-Wolf C, Seldenrijk CA, Das KM, et al. Prevalence of mabDAS-1 positivity in biopsy specimens from the esophagogastric junction. Am J Gastroenterol. 2002;97:2979-2985.
33. Sakamaki S, Takayanagi N, Yoshizaki N, et al. Autoanti-bodies against the specific epitope of human tropomyosin(s) detected by a peptide based enzyme immunoassay in sera of patients with ulcerative colitis show antibody dependent cell mediated cytotoxicity against HLA-DPw9 transfected L cells. Gut. 2000;47: 236-241.
34. Scheppach W, Sommer H, Kirchner T, et al. Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis. Gastroenterology. 1992;103:51-56.
35. Swan NC, Geoghegan JG, O'Donoghue DP, et al. Fulminant colitis in inflammatory bowel disease: detailed pathologic and clinical analysis. Dis Colon Rectum. 1998;41:1511-1515.
36. Takahashi F, Das KM. Isolation and characterization of a colonic autoantigen specifically recognized by colon tissue-bound immuno-globulin G from idiopathic ulcerative colitis. J Clin Invest. 1985; 76:311-318.
37. Taniguchi M, Geng X, Glazier KD, et al. Cellular immune response against tropomyosin isoform 5 in ulcerative colitis. Clin Immunol. 2001;101:289-295.
38. Warren BF, Shepherd NA, Price AB, et al. Importance of cryptolytic lesions and pericryptal granulomas in inflammatory bowel disease. J Clin Pathol. 1997;50:880-881.
39. Yantiss RK, Odze RD. Diagnostic difficulties in inflammatory bowel disease pathology. Histopathology. 2006;48:116-132.
40. Yantiss RK, Farraye FA, O'Brien MJ, et al. Prognostic significance of superficial fissuring ulceration in patients with severe " indeterminate" colitis. Am J Surg Pathol. 2006;30:165-170.