Autoantibodies against human tropomyosin isoform 5 in ulcerative colitis destroys colonic epithelial cells through antibody and complement-mediated lysis

Cellular Immunology

Volumn 244, Issue 1, 2006, Pages 43-49

  Ebert, Ellen C ^a   Geng, Xin ^a   Lin, Jim ^b   Das, Kiron M ^a  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Antibodies; Inflammatory bowel disease; Tropomyosin; Ulcerative colitis

Indexed keywords

AUTOANTIBODY; BOVINE SERUM ALBUMIN; CHROMIUM 51; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; TROPOMYOSIN;

ADULT; AGED; ARTICLE; CELL CULTURE; COLON ADENOCARCINOMA; COMPLEMENT DEPENDENT CYTOTOXICITY; CONTROLLED STUDY; CROHN DISEASE; CYTOTOXICITY; DIAGNOSTIC PROCEDURE; EPITHELIUM CELL; HUMAN; INCUBATION TIME; MAJOR CLINICAL STUDY; PATHOGENESIS; PRIORITY JOURNAL; SERUM; TOTAL COLON RESECTION; ULCERATIVE COLITIS;

AUTOANTIBODIES; COLITIS, ULCERATIVE; COLON; COMPLEMENT PATHWAY, CLASSICAL; CROHN DISEASE; EPITHELIAL CELLS; HUMANS; IMMUNOGLOBULIN G; INTESTINAL MUCOSA; TROPOMYOSIN;

BOVINAE;

EID: 34247485444     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2007.02.004     Document Type: Article

References (24)

1. Broberger O., and Perlman P. Autoantibodies in human ulcerative colitis. J. Exp. Med. 110 (1959) 657
2. Fiocchi C., Roche J.K., and Michener W.M. High prevalence of antibodies to intestinal epithelial antigens in patients with inflammatory bowel disease and their relatives. Ann. Intern. Med. 110 (1989) 786-794
3. Hibi T., Ohara M., Toda K., Hara A., Ogata H., Iwao Y., Watanabe N., Watanabe M., Hamada Y., Kobayashi K., Aiso S., and Tsuchiya M. In vitro anticolon antibody production by mucosal or peripheral blood lymphocytes from patients with ulcerative colitis. Gut 31 (1990) 1371-1376
4. Baklien K., and Brandtzaeg P. Comparative mapping of the local distribution of immunoglobulin-containing cells in ulcerative and Crohn's disease of the colon. Clin. Exp. Immunol. 22 (1975) 197-209
5. Das K.M., Kadono Y., and Fleischner G.M. Antibody-dependent cell-mediated cytotoxicity by sera from patients with idiopathic ulcerative colitis: Its relationship to disease activity and response to total colectomy. Am. J. Med. 77 (1984) 791-796
6. Auer I.O., Grosch L., Hardorfer C., and Roder A. Ulcerative colitis specific cytotoxic IgG-autoantibodies against colonic-epithelial cancer cells. Gut 29 (1990) 1632-1647
7. Hibi T., Ohara M., Watanabe M., Kanai T., Takaishi H., Hayashi A., Hosoda Y., Ogata H., Iwao Y., Aiso S., Watanabe N., Toda K., and Tsuchiya M. Interleukin 2 and interferon-γ augment anticolon antibody dependent cellular cytotoxicity in ulcerative colitis. Gut 34 (1993) 788-793
8. Das K.M., Dasgupta A., Mandal A., et al. Autoimmunity to cytoskeletal protein tropomyosin(s): a new clue to the pathogenic mechanism for ulcerative colitis. J. Immunol. 150 (1993) 2487-2493
9. Lin J.J.-C., Warren K.S., Wamboldt D.D., Wang T., and Lin J.L.-C. Tropomyosin isoforms in nonmuscle cells. Int. Rev. Cytol. 170 (1997) 1-38
10. Geng X., Biancone L., Dai H.H., Lin J.-C., Yoshizaki N., Dasgupta A., Pallone F., and Das K.M. Tropomyosin isoforms in intestinal mucosa: production of autoantibodies to tropomyosin isoforms in ulcerative colitis. Gastroenterology 114 (1998) 912-922
11. Kesari K.V., Yoshizaki N., Geng X., Lin J.J.-C., and Das K.M. Externalization of tropomyosin isoform 5 in colon epithelial cells. Clin. Exp. Immunol. 118 (1999) 219-227
12. Das K.M., Squillante L., and Robertson F. Expression of the Mr 40,000 protein in DLD-1 colon cancer cells and the effect of cytokines. Clin. Exp. Immunol. 88 (1992) 138-142
13. R.P. MacDermott, G.S. Nash, M.H. Nahn, Alterations in IgG subclasses in inflammatory bowel disease, in: Inflammatory Bowel Disease: Current Status and Future Approach. Excerpta Medica, 1988, pp. 61-65.
14. Kett K., Rognum T.O., and Brandtzaeg P. Mucosal subclass distribution of immunoglobulin G-producing cells is different in ulcerative colitis and Crohn's disease of the colon. Gastroenterology 93 (1987) 919-924
15. Halstensen T.S., Mollnes T.E., Garred P., Fausa O., and Brandtzaeg P. Epithelial deposition of immunoglobulin G1 and activated complement (C3b and terminal complement complex) in ulcerative colitis. Gastroenterology 98 (1990) 1264-1271
16. Halstensen T.S., Mollnes T.E., Garred P., Fausa O., and Brandtzaeg P. Surface epithelium-related activation of complement differs in Crohn's disease and ulcerative colitis. Gut 33 (1992) 902-908
17. Takahashi F., and Das K.M. Isolation and characterization of a colonic autoantigen specifically recognized by colon tissue-bound IgG from idiopathic ulcerative colitis. J. Clin. Invest. 76 (1985) 311-318
18. Onuma E.K., Amenta P.S., Ramaswamy K., Lin J.J.-C., and Das K.M. Autoimmunity in ulcerative colitis: a predominant colonic mucosal B cell response against human tropomyosin isoform 5. Clin. Exp. Immunol. 121 (2000) 466-471
19. Taniguchi M., Geng X., Glazier K.D., Dasgupta A., Lin J.J.-C., and Das K.M. Cellular immune response against tropomyosin isoform 5 in ulcerative colitis. Clin. Immunol. 101 (2001) 289-295
20. Das K.M., Liu J., Geng X., and Lin J.J.C. Identification of a specific peptide from human tropomyosin isoform 5 (hTM5) that binds with HLA-DR2 and induces T cells response in ulcerative colitis. Gastroenterology 126 (2004) A152
21. Tatar E., Cohen H.D., Geng X., Mirza Z.K., Glazier K.D., Griffel L.H., Lin J.-C., and Das K.M. Human tropomyosin isoform 5 (hTM5) expression is increased in the colonic mucosa from patients with active ulcerative colitis. Gastroenterology 122 (2002) A531
22. Sakamaki S., Takayanagi N., yoshizaki N., Hayashi S., Takayama T., et al. Autoantibodies against the specific epitope of human tropomyosin(s) detected by a peptide based enzyme immunoassay in sera of patients with ulcerative colitis show antibody dependent cell mediated cytotoxicity against HLA-DPw9 transfected L cells. Gut 47 (2000) 236-241
23. Mirza Z.K., Sastri B., Lin J., Amenta P.S., and Das K.M. Autoimmunity against human tropomyosin isoforms in ulcerative colitis. Localization of specific human tropomyosin isoforms in the intestine and extraintestinal organs. Inflamm. Bowel Dis. 12 (2006) 1036-1043
24. Biancone L., Palmieri G., Lombardi A., Colantoni A., Tonelli F., et al. Tropomyosin expression in the ileal pouch: a relationship with the development of pouchitis in ulcerative colitis. Am. J. Gastroenterol. 98 (2003) 2719-2726