Residues of nitrofuran antibiotic parent compounds and metabolites in eyes of broiler chickens

Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment

Volumn 25, Issue 5, 2008, Pages 548-556

  Cooper, K M ^a   McCracken, R J ^a   Buurman, M ^b   Kennedy, D G ^a  

^a AGRI FOOD AND BIOSCIENCES INSTITUTE   (United Kingdom)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Broiler chickens; Depletion; Eyes; Metabolites; Nitrofurans; Semicarbazide

Indexed keywords

3 AMINO 2 OXAZOLIDINONE; 3 AMINO 5 MORPHOLINOMETHYL 2 OXAZOLIDONE; ANTIBIOTIC AGENT; FURAZOLIDONE; NITROFURAL; NITROFURAN; OXAZOLIDINONE DERIVATIVE; SEMICARBAZIDE; 1 AMINOHYDANTOIN; FURALTADONE; NITROFURAN DERIVATIVE; NITROFURANTOIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL ANALYSIS; CHICKEN MEAT; CONTROLLED STUDY; DEPLETION; EYE; FOOD ANALYSIS; FOOD COMPOSITION; FOOD CONTAMINATION; HALF LIFE TIME; LIQUID CHROMATOGRAPHY; LIVER; MUSCLE; NONHUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; CHICKEN; DRUG HALF LIFE; DRUG METABOLISM; DRUG SENSITIVITY; DRUG TISSUE LEVEL; RESIDUE ANALYSIS;

ANIMALS; ANTI-INFECTIVE AGENTS, URINARY; CHICKENS; CHROMATOGRAPHY, LIQUID; DRUG RESIDUES; EYE; FOOD ANALYSIS; FOOD CONTAMINATION; MEAT; NITROFURANS; SEMICARBAZIDES; TANDEM MASS SPECTROMETRY;

GALLUS GALLUS;

EID: 46249106575     PISSN: 19440049     EISSN: 19440057     Source Type: Journal    
DOI: 10.1080/02652030701586657     Document Type: Article

References (30)

1. Cooper, KM, and Kennedy, DG. 2005. Nitrofuran antibiotic metabolites detected at parts per million concentrations in retina of pigs — a new matrix for enhanced monitoring of nitrofuran abuse. The Analyst, 130:466–468.
2. Cooper, KM, and Kennedy, DG. 2007. Stability studies of the metabolites of nitrofuran antibiotics during storage and cooking. Food Additives and Contaminants, 24:935–942.
3. Cooper, KM, McCracken, RJ, and Kennedy, DG. 2005a. Nitrofurazone accumulates in avian eyes — a replacement for semicarbazide as a marker of abuse. The Analyst, 130:824–827.
4. Cooper, KM, Mulder, PPJ, Van Rhijn, JA, Kovacsics, L, McCracken, RJ, Young, PB, and Kennedy, DG. 2005b. Depletion of four nitrofuran antibiotics and their tissue-bound metabolites in porcine tissues and determination using LC-MS/MS and HPLC-UV. Food Additives and Contaminants, 22:406–414.
5. European Commission. 1995. Commission Regulation (EC) 1442/95, 1995, of 26 June 1995 amending Annexes I, II, III and IV to Regulation (EEC) No. 2377/90 laying down a Community Procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin. Official Journal of the European Communities, L143:26–30.
6. European Commission. 2002a. Commission Decision 2002/251/EC of 27 March 2002 concerning the extension of the protective measures provided by Decision 2001/699/EC, with regard to the fishery and aquaculture products imported from Vietnam. Official Journal of the European Communities, L84:75–76.
7. European Commission. 2002b. Commission Decision 2002/251/EC of 27 March 2002 concerning certain protective measures with regard to poultrymeat and certain fishery and aquaculture products intended for human consumption and imported from Thailand. Official Journal of the European Communities, L84:77–78.
8. European Commission. 2002c. Commission Decision 2002/794/EC of 11 October 2002 concerning certain protective measures with regard to poultrymeat, poultrymeat products and poultrymeat preparations intended for human consumption and imported from Brazil. Official Journal of the European Communities, L276:66–67.
9. European Commission. 2003. Commission Decision 2003/181/EC of 13 March 2003 amending Decision 2002/657/EC as regards the setting of minimum required performance limits (MRPLs) for certain residues in food of animal origin. Official Journal of the European Communities, L71:17–18.
10. European Commission. 2005. Commission Decision 2005/34/EC of 11 January 2005 laying down harmonised standards for the testing for certain residues in products of animal origin imported from third countries. Official Journal of the European Communities, L16:61–63.
11. European Commission Rapid Alert System for Food and Feed (RASFF). n.d. RASFF (available at:http://ec.europa.eu/food/food/rapidalert/archive_en.htm)
12. European Food Safety Authority (EFSA). 2003. Press release 15 October 2003 (available at:http://www.efsa.europa.eu/en/press_room/press_release/2003/30.html)
13. Hoenicke, K, Gatermann, R, Hartig, L, Mandix, M, and Otte, S. 2004. Formation of semicarbazide (SEM) in food by hypochlorite treatment:Is SEM a specific marker for nitrofurazone abuse?. Food Additives and Contaminants, 21:526–537.
14. Hoogenboom, LAP, Tomassini, O, Oorsprong, MBM, and Kuiper, HA. 1991. The use of pig hepatocytes to study the inhibition of monoamine oxidase by furazolidone. Food and Chemical Toxicology, 29:185–191.
15. Ings, RMJ. 1984. The melanin binding of drugs and its implications. Drug Metabolism Reviews, 15:1183–1212.
16. Kennedy, DG, Van Rhijn, JA, and Kanarat, S. Azodicarbonamide, a flour treatment agent, produces semicarbazide residues in bread. Proceedings of the EuroResidue V Conference. May122004, Noordwijkerhout, the Netherlands. Edited by:Van Ginkel, LA, and Bergwerff, AA. pp. 612–617. Bilthoven:RIVM.
17. Malucelli, A, Ellendorff, F, and Meyer, HHD. 1994. Tissue distribution and residues of clenbuterol, salbutamol, and terbutaline in tissues of treated broiler chickens. Journal of Animal Science, 72:1555–1560.
18. McCracken, RJ, Blanchflower, WJ, Rowan, C, McCoy, MA, and Kennedy, DG. 1995. Determination of furazolidone in porcine tissue using thermospray liquid chromatography-mass spectrometry and a study of the pharmacokinetics and stability of its residues. Analyst, 120:2347–2351.
19. McCracken, RJ, and Kennedy, DG. 2007. The detection, accumulation and distribution of nitrofuran residues in egg yolk, albumen and shell. Food Additives and Contaminants, 24:26–33.
20. McCracken, RJ, McCoy, MA, and Kennedy, DG. 1997. The prevalence and possible causes of bound and extractable residues of the furazolidone metabolite 3-amino-2-oxazolidinone in porcine tissues. Food Additives and Contaminants, 14:287–294.
21. McCracken, RJ, Van Rhijn, JA, and Kennedy, DG. 2005. The occurrence of nitrofuran metabolites in the tissues of chickens exposed to very low dietary concentrations of the nitrofurans. Food Additives and Contaminants, 22:567–572.
22. National Office of Animal Health Ltd. 1992. Compendium of data sheets for veterinary products 1992–93., 346London:Datapharm.
23. O’Keeffe, M, Conneely, A, Cooper, KM, Kennedy, DG, Kovacsics, L, Fodor, A, Mulder, PPJ, Van Rhijn, JA, and Trigueros, G. 2004. Nitrofuran antibiotic residues in pork:The FoodBRAND retail survey. Analytica Chimica Acta, 520:125–131.
24. Pereira, AS, Donato, JL, and De Nucci, G. 2004. Implications of the use of semicarbazide as a metabolic target of nitrofurazone contamination in coated products. Food Additives and Contaminants, 21:63–69.
25. Saari, L, and Peltonen, K. 2004. Novel source of semicarbazide:Levels of semicarbazide in cooked crayfish samples determined by LC/MS/MS. Food Additives and Contaminants, 21:825–832.
26. Sanders, P. 2003. Community Reference Laboratory website (available at:http://www.crl.fougeres.afssa.fr/publicdoc/noteCRL281103.pdf)
27. Stadler, RH, Mottier, P, Guy, P, Gremaud, E, Varga, N, Lalljie, S, Whitaker, R, Kintscher, J, Dudler, V, Read, WA. 2004. Semicarbazide is a minor thermal decomposition product of azodicarbonamide used in the gaskets of certain food jars. Analyst, 129:276–281.
28. UK Food Standards Agency. Press release 4 March 2003 (available at:http://www.foodstandards.gov.uk/news/pressreleases/2003/mar/portugesechickens)
29. Van Koten-Vermeulen, JEM, Wouters, MFA, and Van Leeuwen, FXR. The development and implementation of manufacturing automation systems using smart mechatronics components. Report of the 40th Meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). pp. 85–123. Geneva:World Health Organisation.
30. Zuidema, T, Van Rhijn, JA, Schat, B, Mulder, PPJ, Bolck, YJC, Hoogenboom, LAP, and Kennedy, DG. Metabolism and depletion of furazolidone and furaltadone in broilers. Proceedings of the EuroResidue V Conference. May122004, Noordwijkerhout, the Netherlands. Edited by:Van Ginkel, LA, and Bergwerff, AA. pp. 996–1001. Bilthoven:RIVM.