Plasminogen alleles influence susceptibility to invasive aspergillosis

PLoS Genetics

Volumn 4, Issue 6, 2008, Pages

  Zaas, Aimee K ^a   Liao, Guochun ^b   Chien, Jason W ^c   Weinberg, Clarice ^d   Shore, David ^d   Giles, Steven S ^e   Marr, Kieren A ^c,f   Usuka, Jonathan ^b   Burch, Lauranell H ^d   Perera, Lalith ^d   Perfect, John R ^a   Peltz, Gary ^b   Schwartz, David A ^d,g  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b ROCHE BIOSCIENCE   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^g NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLASMINOGEN;

ALLELE; ANIMAL EXPERIMENT; ARTICLE; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; CONTROLLED STUDY; FEMALE; GENETIC ANALYSIS; GENETIC DIFFERENCE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HAPLOTYPE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; A J MOUSE; AKR MOUSE; ANIMAL; BAGG ALBINO MOUSE; C3H MOUSE; C57BL MOUSE; COMPARATIVE STUDY; DBA MOUSE; GENETIC PREDISPOSITION; GENETICS; HUMAN; IMMUNOLOGY; LUNG MYCOSIS; MICROBIOLOGY; MORTALITY; MOUSE MUTANT; MURPHY ROTHS LARGE LYMPHOPROLIFERATIVE MOUSE; NEW ZEALAND BLACK MOUSE; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ASPERGILLUS FUMIGATUS; MURINAE;

ALLELES; ANIMALS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LUNG DISEASES, FUNGAL; MICE; MICE, INBRED A; MICE, INBRED AKR; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, INBRED MRL LPR; MICE, INBRED NZB; MICE, KNOCKOUT; PLASMINOGEN; SIGNAL TRANSDUCTION;

EID: 46249104101     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000101     Document Type: Article

References (54)

1. Herbrecht R, Denning DW, Patterson TF, Bennett JE, Greene RE, et al. (2002) Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl J Med 347: 408-415.
2. Marr KA, Carter RA, Boeckh M, Martin P, Corey L (2002) Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors. Blood 100: 4358-4366.
3. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, et al. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282: 2085-2088.
4. Grupe A, Germer S, Usuka J, Aud D, Belknap JK, et al. (2001) In silico mapping of complex disease-related traits in mice. Science 292: 1915-1918.
5. Guo Y, Weller P, Farrell E, Cheung P, Fitch B, et al. (2006) In silico pharmacogenetics of warfarin metabolism. Nat Biotechnol 24: 531-536.
6. Liao G, Wang J, Guo J, Allard J, Cheng J, et al. (2004) In silico genetics: identification of a functional element regulating H2-Ealpha gene expression. Science 306: 690-695.
7. Bianchini R, Nocentini G, Krausz LT, Fettucciari K, Coaccioli S, et al. (2006) Modulation of pro- and antiapoptotic molecules in double-positive (CD4+CD8+) thymocytes following dexamethasone treatment. J Pharmacol Exp Ther 319: 887-897.
8. Berge A, Sjobring U (1993) PAM, a novel plasminogen-binding protein from Streptococcus pyogenes. J Biol Chem 268: 25417-25424.
9. Bower K, Djordjevic SP, Andronicos NM, Ranson M (2003) Cell surface antigens of Mycoplasma species bovine group 7 bind to and activate plasminogen. Infect Immun 71: 4823-4827.
10. Boyle MD, Lottenberg R (2000) The interaction of pathogens with humans. Methods 21: 99-102.
11. Coleman JL, Benach JL (1999) Use of the plasminogen activation system by microorganisms. J Lab Clin Med 134: 567-576.
12. Collen D, Schlott B, Engelborghs Y, Van Hoef B, Hartmann M, et al. (1993) On the mechanism of the activation of human plasminogen by recombinant staphylokinase. J Biol Chem 268: 8284-8289.
13. Crowe JD, Sievwright IK, Auld GC, Moore NR, Gow NA, et al. (2003) Candida albicans binds human plasminogen: identification of eight plasminogen-binding proteins. Mol Microbiol 47: 1637-1651.
14. Fox D, Smulian AG (2001) Plasminogen-binding activity of enolase in the opportunistic pathogen Pneumocystis carinii. Med Mycol 39: 495-507.
15. Levi M, van der Poll T (2005) Two-way interactions between inflammation and coagulation. Trends Cardiovasc Med 15: 254-259.
16. Sanderson-Smith M, Batzloff M, Sriprakash KS, Dowton M, Ranson M, et al. (2006) Divergence in the plasminogen-binding group a streptococcal M protein family: functional conservation of binding site and potential role for immune selection of variants. J Biol Chem 281: 3217-3226.
17. Sodeinde OA, Sample AK, Brubaker RR, Goguen JD (1988) Plasminogen activator/coagulase gene of Yersinia pestis is responsible for degradation of plasmid-encoded outer membrane proteins. Infect Immun 56: 2749-2752.
18. Sun H, Ringdahl U, Homeister JW, Fay WP, Engleberg NC, et al. (2004) Plasminogen is a critical host pathogenicity factor for group A streptococcal infection. Science 305: 1283-1286.
19. Suenson E, Thorsen S (1981) Secondary-site binding of Glu-plasmin, Lys-plasmin and miniplasmin to fibrin. Biochem J 197: 619-628.
20. Ho-Tin-Noe B, Rojas G, Vranckx R, Lijnen HR, Angles-Cano E (2005) Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis. Febs J 272: 3387-3400.
21. Gong Y, Kim SO, Felez J, Grella DK, Castellino FJ, et al. (2001) Conversion of Glu-plasminogen to Lys-plasminogen is necessary for optimal stimulation of plasminogen activation on the endothelial cell surface. J Biol Chem 276: 19078-19083.
22. Lahteenmaki K, Kuusela P, Korhonen TK (2001) Bacterial plasminogen activators and receptors. FEMS Microbiol Rev 25: 531-552.
23. Jong AY, Chen SH, Stins MF, Kim KS, Tuan TL, et al. (2003) Binding of Candida albicans enolase to plasmin(ogen) results in enhanced invasion of human brain microvascular endothelial cells. J Med Microbiol 52: 615-622.
24. Ge J, Catt DM, Gregory RL (2004) Streptococcus mutans surface alpha-enolase binds salivary mucin MG2 and human plasminogen. Infect Immun 72: 6748-6752.
25. Bouchara JP, Sanchez M, Esnault K, Tronchin G (1999) Interactions between Aspergillus fumigatus and host matrix proteins. Contrib Microbiol 2: 167-181.
26. Tronchin G, Esnault K, Renier G, Filmon R, Chabasse D, et al. (1997) Expression and identification of a laminin-binding protein in Aspergillus fumigatus conidia. Infect Immun 65: 9-15.
27. Mitchell JW, Baik N, Castellino FJ, Miles LA (2006) Plasminogen Inhibits TNF{alpha}-induced Apoptosis in Monocytes. Blood.
28. Ploplis VA, French EL, Carmeliet P, Collen D, Plow EF (1998) Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice. Blood 91: 2005-2009.
29. Syrovets T, Schule A, Jendrach M, Buchele B, Simmet T (2002) Ciglitazone inhibits plasmin-induced proinflammatory monocyte activation via modulation of p38 MAP kinase activity. Thromb Haemost 88: 274-281.
30. Weide I, Tippler B, Syrovets T, Simmet T (1996) Plasmin is a specific stimulus of the 5-lipoxygenase pathway of human peripheral monocytes. Thromb Haemost 76: 561-568.
31. Kesh S, Mensah NY, Peterlongo P, Jaffe D, Hsu K, et al. (2005) TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Ann N Y Acad Sci 1062: 95-103.
32. Seo KW, Kim DH, Sohn SK, Lee NY, Chang HH, et al. (2005) Protective role of interleukin-10 promoter gene polymorphism in the pathogenesis of invasive pulmonary aspergillosis after allogeneic stem cell transplantation. Bone Marrow Transplant 36: 1089-1095.
33. Bellocchio S, Bozza S, Montagnoli C, Perruccio K, Gaziano R, et al. (2005) Immunity to Aspergillus fumigatus: the basis for immunotherapy and vaccination. Med Mycol 43 Suppl 1: S181-188.
34. Bellocchio S, Moretti S, Perruccio K, Fallarino F, Bozza S, et al. (2004) TLRs govern neutrophil activity in aspergillosis. J Immunol 173: 7406-7415.
35. Dubourdeau M, Athman R, Balloy V, Huerre M, Chignard M, et al. (2006) Aspergillus fumigatus induces innate immune responses in alveolar macrophages through the MAPK pathway independently of TLR2 and TLR4. J Immunol 177: 3994-4001.
36. Meier A, Kirschning CJ, Nikolaus T, Wagner H, Heesemann J, et al. (2003) Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages. Cell Microbiol 5: 561-570.
37. Netea MG, Warris A, Van der Meer JW, Fenton MJ, Verver-Janssen TJ, et al. (2003) Aspergillus fumigatus evades immune recognition during germination through loss of toll-like receptor-4-mediated signal transduction. J Infect Dis 188: 320-326.
38. Overland G, Stuestol JF, Dahle MK, Myhre AE, Netea MG, et al. (2005) Cytokine responses to fungal pathogens in Kupffer Cells are Toll-like receptor 4 independent and mediated by tyrosine kinases. Scand J Immunol 62: 148-154.
39. Hector RF, Yee E, Collins MS (1990) Use of DBA/2N mice in models of systemic candidiasis and pulmonary and systemic aspergillosis. Infect Immun 58: 1476-1478.
40. Hinners RG, Burkart JK, Contner GL (1966) Animal exposure chambers in air pollution studies. Arch Environ Health 13: 609-615.
41. Steinbach WJ, Benjamin DK Jr, Trasi SA, Miller JL, Schell WA, et al. (2004) Value of an inhalational model of invasive aspergillosis. Med Mycol 42: 417-425.
42. Guo Y, Lu P, Farrell E, Zhang X, Weller P, et al. (2007) In silico and in vitro pharmacogenetic analysis in mice. Proc Natl Acad Sci U S A 104: 17735-17740.
43. Wang J, Liao G, Usuka J, Peltz G (2005) Computational genetics: from mouse to human? Trends Genet 21: 526-532.
44. Wang JaPG (2005) Haplotype-Based Computational Genetic Analysis in Mice. In: Peltz G, ed. Computational Genetics and Genomics Tools for Understanding Disease Palo Alto, CA: Humana Press. pp 51-70.
45. Bowman JC, Abruzzo GK, Anderson JW, Flattery AM, Gill CJ, et al. (2001) Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: demonstration of efficacy of caspofungin acetate. Antimicrob Agents Chemother 45: 3474-3481.
46. Walsh TJ, McEntee C, Dixon DM (1987) Tissue homogenization with sterile reinforced polyethylene bags for quantitative culture of Candida albicans. J Clin Microbiol 25: 931-932.
47. Wall FE, Henkel RD, Stern MP, Jenson HB, Moyer MP (1995) An efficient method for routine Epstein-Barr virus immortalization of human B lymphocytes. In Vitro Cell Dev Biol Anim 31: 156-159.
48. Ascioglu S, Rex JH, de Pauw B, Bennett JE, Bille J, et al. (2002) Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 34: 7-14.
49. Lee E (1980) Statistical Methods for Survival Data Analysis. Belmont, California: Lifetime Learning Publications.
50. Prentice R, Mason MW (1986) EPICURE User's Guide: Hirosoft International.
51. Greenland S, Pearl J, Robins JM (1999) Causal diagrams for epidemiologic research. Epidemiology 10: 37-48.
52. Cornell WD, Cieplak P, Bayly CI, Gould IR, Merz Jr KM, Ferguson DM, Spellmeyer DC, Fox T, Caldwell JW, Kollman PA, A second generation force field for, the simulation of proteins na, and organic molecules (1995) A second generation force field for the simulation of proteins, nucleic acids, and organic molecules. J Am Chem Soc 117: 5179-5197.
53. Case TAD DA, Cheatham TE, Simmerling CL, Wang J, Duke RE, R, Luo KMM, Pearlman DA, et al. (2006) AMBER 9. San Francisco, CA.
54. Nicholls A, Sharp KA, Honig B (1991) Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins 11: 281-296.