Citrus polymethoxylated flavones: Blood-lipid lowering and anticancerogenic effects;Polymethoxyflavone in Zitrusfrüchten: Blutlipidsenkende und antikanzerogene Eigenschaften

Ernahrungs Umschau

Volumn 55, Issue 5, 2008, Pages 290-295

  Schmandke, H ^a  

^a NONE

Author keywords

Anti cancer activity; Lowering of blood lipids; Nobiletin; Polymethoxylated flavones; Tangeretin

Indexed keywords

CITRUS; MUS;

EID: 46249086306     PISSN: 01740008     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Nelson EK (1934) The occurrence of a pentamethyl flavonol in tangerine peel. J Am Chem Soc 56; 1392-1393
2. Chen J et al. (1997) Two new polymethoxylated flavones, a class of compounds with anticancer activity, isolated from cold pressed. Dancy tangerine oil solids, J Agric Food Chem 45; 364-368
3. Tseng KF (1938); Chem SOC (Tondon), 1003; zit. in [23]
4. Born R (1960); Chem Ind (London), 264; zit. in [23]
5. Swift LJ (1967) TLC-spectrophotometric analysis for neutral fraction flavones in orange peel juice. J Agric Tood Chem 15; 99-101
6. Robbins RC (1980) Medical and nutritional aspects of citrus bioflavonoids. ACS Symposium Series, Washington 143; 43-62
7. Barbera'n FAT et al. (1985) Highly methylated 6-hydroxyflavones and. other flavonoids from Thymus piperella. Planta Medica 51; 452-454
8. Nieto S et al. (1993) Flavonoids as stabilizers of fish oil: an alternative to synthetic antioxidants. J Am Oil Chemists'Soc 70; 773-778
9. Muschiolik G, Schmandke H (2000) Funktionelle Eigenschaften von Ackerbohnenprodukten (Vicia faba). Shaker Verlag Aachen, S. 18-19 u. 30-31
10. Ekambaram G et al. (2008) Naringenin reduces tumor size and weight lost in N-methyl-N'-nitro-N-nitrosoguani-dine-induced gastric carcinogenesis in rats. Nutr Res 28; 106-112
11. Kurowska EM, Manthey JA (2004) Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. J Agric Food Chem 52; 2879-2886
12. Saito T et al. (2007) Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes. Biochem Biophys Res Commun 357; 371-376
13. Whitman SC et al. (2005) Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits das A scavenger receptor-mediated metabolism of acylaled LDL by mouse macrophages. Atherosclerosis 178; 25-32
14. Eguchi A et al. (2006) Nobiletin, a citrus flavonoid, suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells. FEBS Lett 580; 3321-3328
15. Rooprai HK et al. (2001) Evaluation of the effects of swainsonine, Captopril, tangeretin and nobiletin on the biological behaviour of brain tumor cells in vitro. Neuropalhol Appl Neurobiol 27; 29-39
16. Hirano T et al. (1995) Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes. Brit J Cancer 72; 1380-1388
17. Kawabata K et al. (2005) Nobiletin, a citrus flavonoid, down-regulates matrix metallo-proteinase-7 (matrilysin) expression in HAT-29 human colorectal cancer cells. Biosci Biotechnol Biochem 69; 307-314
18. Sato T et al. (2002) Inhibition of activator protein-1 binding activity and phosphatidyl-inositol 3-kinase pathway by nobiletin, a polymethoxy flvonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells. Cancer Res 62; 1025-1029
19. Miyata Y et al. (2004) Activation of protein kinase CßII/e-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymelhoxy-flavonoid, nobiletin. Mol Cancer Ther 3; 839-847
20. Minagawa A et al. (2001) The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice, Jpn J Cancer Res 92; 1322-1328
21. Sergeev IN et al. (2007) Apoptosis-inducing activity of hydroxylated polymethoxy-flavones and polymethoxy-flavones from orange peel in human breast cancer cells. Mol Nutr Food Res 51; 1478-1484
22. Li S et al. (2006) Hydroxylated polymethoxyflavons and methylated fla-vonoids in sweet orange (Citrus sinensis') peel. J Agric Fodd Chem 54; 4176-4185
23. Gayclou EM et al. (1987) Orange and mandarin peel oils differentiation using polymethoxflated flavone composition. J Agric Food Chem 35; 525-529
24. Mizuno M et al. (1991) Chemotaxonomy of the genus citrus based on polymethoxy-flavones. Chem Pharm Bull 39; 945-949
25. Kawaii S et al. (1999) HL-60 differentiating activity and flavonoid content of the readily extractable fraction prepared from citrus juices. J Agric Food Chem 47; 128-135
26. Ovaskainen M-L et al. (2008) Dietary intake and major food sources of polyphenols in Finnish adults. J Nutr 136; 562-566
27. Dills V et al. (2007) The flavone, flavonol and flavan-3-ol content in the Greek traditional diet. Food Chem 105; 812-821
28. Nielsen SE et al. (2000) Biotransformation of the citrus flavone tangeretin in rats. Chem Toxicol 38; 739-746
29. Breinholt VM et al. (2003) In vitro metabolism of genistein and tangeretin by human and murine cytochrome P450s. Pharmacol Toxicol 93; 14-22
30. Murakami A el al. (2001) In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits. Biosci Biotechnol Biochem 65; 194-197
31. Murakami A et al. (2002) Characteristic rat tissue accumulation of nobiletin, a chemopreventive polymethoxyflavonoid, in companion with luteolin. Biofactors 16; 73-82
32. Kurowska EM et al. (2004) Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, tangeretin. Lipids 39; 143-151
33. Manthey JA, Guthrie N (2002) Antiproliferative activities of Citrus flavonoids against six human cancer cell lines. J Agric Food Chem 50; 5837-5843
34. Kandaswami C et al. (1991) Antiproliferatve effects of citrus flavonoids on a human squamous cell carcinoma in vitro. Cancer Lett 56; 147-152
35. Murakami A et al. (2000) Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice. Cancer Res 60; 5059-5066
36. Miyata Y et al. (2008) Citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT1080 cells. Biochem and Biophys Res Comm 366; 168-173