Increased susceptibility to endotoxic shock in transgenic rats with endothelial overexpression of kinin B1 receptors

Journal of Molecular Medicine

Volumn 86, Issue 7, 2008, Pages 791-798

  Merino, Vanessa F ^a,b   Todiras, Mihail ^a   Campos, Luciana A ^a   Saul, Vera ^a   Popova, Elena ^a   Baltatu, Ovidiu C ^a   Pesquero, João B ^b   Bader, Michael ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Endothelium; Endotoxic shock; Hypotension; Kinin B1 receptor; Transgenic

Indexed keywords

BRADYKININ B1 RECEPTOR; BRADYKININ B1 RECEPTOR AGONIST; BRADYKININ B2 RECEPTOR; LIPOPOLYSACCHARIDE; NITRIC OXIDE; POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; BRADYCARDIA; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; GENE OVEREXPRESSION; HOMEOSTASIS; HYPOTENSION; INFLAMMATION; MALE; MORTALITY; NONHUMAN; PATHOGENESIS; RAT; SEPTIC SHOCK; TRANSGENIC RAT; VASCULAR ENDOTHELIUM; VASODILATATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOOD PRESSURE; CAPILLARY PERMEABILITY; ENDOTHELIUM, VASCULAR; LIPOPOLYSACCHARIDES; MALE; RATS; RECEPTOR, BRADYKININ B1; SHOCK, SEPTIC; TIME FACTORS;

EID: 46149110502     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-008-0345-z     Document Type: Article

References (37)

1. Bhoola KD, Figueroa CD, Worthy K (1992) Bioregulation of kinins: kallikreins, kininogens and kininases. Pharmacol Rev 44:1-80
2. Regoli DC, Marceau F, Lavigne J (1981) Induction of beta 1-receptors for kinins in the rabbit by a bacterial lipopolysaccharide. Eur J Pharmacol 71:105-115
3. 1 receptors for kinins. Pharmacol Rev 50:357-386
4. 1 receptor and leukocyte trafficking across mouse mesenteric post-capillary venules. J Exp Med 192:367-380
5. 1-receptor in cultured human lung fibroblasts. J Clin Invest 101:2080-2091
6. 2 receptor on nociception in rats and mice. Pain 71:89-97
7. 1 receptors in the polymorphonuclear leucocyte accumulation induced by IL-1b in vivo in the mouse. J Immunol 156:269-274
8. 1 receptors. Proc Natl Acad Sci USA 97:8140-8145
9. 1 receptor-deficient mice. Biol Chem 382:91-95
10. 1 receptor for therapeutic angiogenesis. Circulation 105:360-366
11. 9-bradykinin and susceptibility to inflammation. J Biol Chem 278:219-225
12. McLean PG, Perretti M, Ahluwalia A (2000) Kinin B(1) receptors and the cardiovascular system: regulation of expression and function. Cardiovasc Res 48:194-210
13. Schlaeger TM, Bartunkova S, Lawitts JA, Teichmann G, Risau W, Deutsch U, Sato TN (1997) Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice. Proc Natl Acad Sci USA 94:3058-3063
14. Alenina N, Baranova T, Smirnow E, Bader M, Lippoldt A, Patkin E, Walther T (2002) Cell type-specific expression of the Mas proto-oncogene in testis. J Histochem Cytochem 50:691-696
15. Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T (2003) Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci USA 100:8258-8263
16. Sirois MG, Plante GE, Braquet P, Sirois P (1990) Role of eicosanoids in PAF-induced increases of the vascular permeability in rat airways. Br J Pharmacol 101:896-900
17. 1 receptor. J Biol Chem 277:16847-16852
18. 1-kinin receptor expression and signaling in endothelial cells. Biochem Biophys Res Commun 345:652-659
19. 1 receptor agonists. Am J Physiol Heart Circ Physiol 284:1959-1968
20. 9bradykinin-induced coronary vasodilation. Br J Pharmacol 128:275-282
21. Liesmaa I, Kuoppala A, Shiota N, Kokkonen JO, Kostner K, Mayranpaa M, Kovanen PT, Lindstedt KA (2005) Increased expression of bradykinin type-1 receptors in endothelium of intramyocardial coronary vessels in human failing hearts. Am J Physiol Heart Circ Physiol 288:2317-2322
22. + channels. Eur J Pharmacol 498:163-169
23. Raidoo DM, Ramsaroop R, Naidoo S, Müller-Esterl W, Bhoola KD (1997) Kinin receptors in human vascular tissue: their role in atheromatous disease. Immunopharmacology 36:153-160
24. 1 receptor synthesis in the rat: an ex vivo study. Br J Pharmacol 125:812-816
25. Regoli D, Barabe J, Park WK (1977) Receptors for bradykinin in rabbit aortae. Can J Physiol Pharmacol 55:855-867
26. 1 receptor in stroke-prone spontaneously hypertensive rats. Hypertens Res 27:399-408
27. 9-BK in mouse pleurisy. Br J Pharmacol 123:281-291
28. 1 receptors in the maintenance of intra-articular plasma extravasation in chronic antigen-induced arthritis. Br J Pharmacol 113:940-944
29. 7]-bradykinin, a bradykinin antagonist, reduces mortality in a rat model of endotoxic shock. Circ Shock 27:93-101
30. Whalley ET, Solomon JA, Modafferi DM, Bonham KA, Cheronis JC (1992) CP-0127, a novel potent bradykinin antagonist, increases survival in rat and rabbit models of endotoxin shock. Agents Actions Suppl 38:413-420
31. Ueno A, Ishida H, Oh-Ishi S (1995) Comparative study of endotoxin-induced hypotension in kininogen-deficient rats with that in normal rats. Br J Pharmacol 114:1250-1256
32. Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M, Ahluwalia A (2007) A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5. J Immunol 179:4849-4856
33. Cayla C, Todiras M, Iliescu R, Saul V, Gross V, Pilz B, Chai G, Merino VF, Pesquero JB, Baltatu OC, Bader M (2007) Mice deficient for both kinin receptors are normotensive and protected from endotoxin-induced hypotension. FASEB J 21:1689-1698
34. Duka I, Kintsurashvili E, Gavras I, Johns C, Bresnahan M, Gavras H (2001) Vasoactive potential of the B(1) bradykinin receptor in normotension and hypertension. Circ Res 88:275-281
35. 1 receptor for kinins, in the anesthetized rabbit pretreated with a sublethal dose of bacterial lipopolysaccharide. J Pharmacol Exp Ther 280:6-15
36. Tatsumi T, Akashi K, Keira N, Matoba S, Mano A, Shiraishi J, Yamanaka S, Kobara M, Hibino N, Hosokawa S, Asayama J, Fushiki S, Fliss H, Nakagawa M, Matsubara H (2004) Cytokine-induced nitric oxide inhibits mitochondrial energy production and induces myocardial dysfunction in endotoxin-treated rat hearts. J Mol Cell Cardiol 37:775-784
37. 1 bradykinin receptors and carboxypeptidase M are both upregulated in the aorta of pigs after LPS infusion. Biochem Biophys Res Commun 243:246-252