-
1
-
-
0032506273
-
Mechanism of action of fibrates on lipid and lipoprotein metabolism
-
Staels B, Dallongeville J, Auwerx J, Schoonjans K, Leitersdorf E, Fruchart JC: Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 1998; 98: 2088-2093.
-
(1998)
Circulation
, vol.98
, pp. 2088-2093
-
-
Staels, B.1
Dallongeville, J.2
Auwerx, J.3
Schoonjans, K.4
Leitersdorf, E.5
Fruchart, J.C.6
-
3
-
-
0027466627
-
Mechanism of action of fibrates
-
Shepherd J: Mechanism of action of fibrates. Postgrad Med J 1993; 69 (Suppl 1): S34-S41.
-
(1993)
Postgrad Med J
, vol.69
, Issue.SUPPL. 1
-
-
Shepherd, J.1
-
4
-
-
0027225298
-
Fenofibrate and LDL metabolic heterogeneity in hypercholesterolemia
-
Caslake MJ, Packard CJ, Gaw A, et al: Fenofibrate and LDL metabolic heterogeneity in hypercholesterolemia. Arterioscler Thromb 1993; 13: 702-711.
-
(1993)
Arterioscler Thromb
, vol.13
, pp. 702-711
-
-
Caslake, M.J.1
Packard, C.J.2
Gaw, A.3
-
5
-
-
0029791412
-
PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene
-
Schoonjans K, Peinado-Onsurbe J, Lefebvre AM, et al: PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J 1996; 15: 5336-5348.
-
(1996)
EMBO J
, vol.15
, pp. 5336-5348
-
-
Schoonjans, K.1
Peinado-Onsurbe, J.2
Lefebvre, A.M.3
-
6
-
-
0020533327
-
Effects of clofibrate, bezafibrate, fenofibrate and probucol on plasma lipolytic enzymes in normolipaemic subjects
-
Heller F, Harvengt C: Effects of clofibrate, bezafibrate, fenofibrate and probucol on plasma lipolytic enzymes in normolipaemic subjects. Eur J Clin Pharmacol 1983; 25: 57-63.
-
(1983)
Eur J Clin Pharmacol
, vol.25
, pp. 57-63
-
-
Heller, F.1
Harvengt, C.2
-
7
-
-
0026488464
-
Perturbation of developmental gene expression in rat liver by fibric acid derivatives: Lipoprotein lipase and alpha-fetoprotein as models
-
Staels B, Auwerx J: Perturbation of developmental gene expression in rat liver by fibric acid derivatives: lipoprotein lipase and alpha-fetoprotein as models. Development 1992; 115: 1035-1043.
-
(1992)
Development
, vol.115
, pp. 1035-1043
-
-
Staels, B.1
Auwerx, J.2
-
8
-
-
0028817459
-
Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates
-
Staels B, Vu-Dac N, Kosykh VA, et al: Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates. J Clin Invest 1995; 95: 705-712.
-
(1995)
J Clin Invest
, vol.95
, pp. 705-712
-
-
Staels, B.1
Vu-Dac, N.2
Kosykh, V.A.3
-
9
-
-
0021954138
-
Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III
-
Wang CS, McConathy WJ, Kloer HU, Alaupovic P: Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III. J Clin Invest 1985; 75: 384-390.
-
(1985)
J Clin Invest
, vol.75
, pp. 384-390
-
-
Wang, C.S.1
McConathy, W.J.2
Kloer, H.U.3
Alaupovic, P.4
-
10
-
-
0034993832
-
Peroxisome proliferator-activated receptors: From transcriptional control to clinical practice
-
Torra IP, Chinetti G, Duval C, Fruchart JC, Staels B: Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice. Curr Opin Lipidol 2001; 12: 245-254.
-
(2001)
Curr Opin Lipidol
, vol.12
, pp. 245-254
-
-
Torra, I.P.1
Chinetti, G.2
Duval, C.3
Fruchart, J.C.4
Staels, B.5
-
11
-
-
0031748864
-
Regulation of apo A-I gene expression by fibrates
-
Staels B, Auwerx J: Regulation of apo A-I gene expression by fibrates. Atherosclerosis 1998; 137 (Suppl): S19-S23.
-
(1998)
Atherosclerosis
, vol.137
, Issue.SUPPL.
-
-
Staels, B.1
Auwerx, J.2
-
12
-
-
0029131206
-
Regulation of rat liver apolipoprotein A-I, apolipoprotein A-II and acyl-coenzyme A oxidase gene expression by fibrates and dietary fatty acids
-
Berthou L, Saladin R, Yaqoob P, et al: Regulation of rat liver apolipoprotein A-I, apolipoprotein A-II and acyl-coenzyme A oxidase gene expression by fibrates and dietary fatty acids. Eur J Biochem 1995; 232: 179-187.
-
(1995)
Eur J Biochem
, vol.232
, pp. 179-187
-
-
Berthou, L.1
Saladin, R.2
Yaqoob, P.3
-
13
-
-
0033594810
-
PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells
-
Marx N, Sukhova GK, Collins T, Libby P, Plutzky J: PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 1999; 99: 3125-3131.
-
(1999)
Circulation
, vol.99
, pp. 3125-3131
-
-
Marx, N.1
Sukhova, G.K.2
Collins, T.3
Libby, P.4
Plutzky, J.5
-
14
-
-
0034614270
-
Activation of PPARalpha or gamma reduces secretion of matrix metalloproteinase 9 but not interleukin 8 from human monocytic THP-1 cells
-
Shu H, Wong B, Zhou G, et al: Activation of PPARalpha or gamma reduces secretion of matrix metalloproteinase 9 but not interleukin 8 from human monocytic THP-1 cells. Biochem Biophys Res Commun 2000; 267: 345-349.
-
(2000)
Biochem Biophys Res Commun
, vol.267
, pp. 345-349
-
-
Shu, H.1
Wong, B.2
Zhou, G.3
-
15
-
-
0035895313
-
PPARalpha agonists inhibit tissue factor expression in human monocytes and macrophages
-
Neve BP, Corseaux D, Chinetti G, et al: PPARalpha agonists inhibit tissue factor expression in human monocytes and macrophages. Circulation 2001; 103: 207-212.
-
(2001)
Circulation
, vol.103
, pp. 207-212
-
-
Neve, B.P.1
Corseaux, D.2
Chinetti, G.3
-
16
-
-
0032475922
-
Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages
-
Chinetti G, Griglio S, Antonucci M, et al: Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages. J Biol Chem 1998; 273: 25573-25580.
-
(1998)
J Biol Chem
, vol.273
, pp. 25573-25580
-
-
Chinetti, G.1
Griglio, S.2
Antonucci, M.3
-
17
-
-
2242436246
-
Reduction of atherosclerosis by the peroxisome proliferator-activated receptor alpha agonist fenofibrate in mice
-
Duez H, Chao YS, Hernandez M, et al: Reduction of atherosclerosis by the peroxisome proliferator-activated receptor alpha agonist fenofibrate in mice. J Biol Chem 2002; 277: 48051-48057.
-
(2002)
J Biol Chem
, vol.277
, pp. 48051-48057
-
-
Duez, H.1
Chao, Y.S.2
Hernandez, M.3
-
18
-
-
0042568979
-
The peroxisome-proliferator-activated receptor alpha agonist ciprofibrate severely aggravates hypercholesterolaemia and accelerates the development of atherosclerosis in mice lacking apolipoprotein E
-
Fu T, Kashireddy P, Borensztajn J: The peroxisome-proliferator-activated receptor alpha agonist ciprofibrate severely aggravates hypercholesterolaemia and accelerates the development of atherosclerosis in mice lacking apolipoprotein E. Biochem J 2003; 373: 941-947.
-
(2003)
Biochem J
, vol.373
, pp. 941-947
-
-
Fu, T.1
Kashireddy, P.2
Borensztajn, J.3
-
19
-
-
3142580930
-
The peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist ciprofibrate inhibits apolipoprotein B mRNA editing in low density lipoprotein receptor-deficient mice: Effects on plasma lipoproteins and the development of atherosclerotic lesions
-
Fu T, Mukhopadhyay D, Davidson NO, Borensztajn J: The peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist ciprofibrate inhibits apolipoprotein B mRNA editing in low density lipoprotein receptor-deficient mice: effects on plasma lipoproteins and the development of atherosclerotic lesions. J Biol Chem 2004; 279: 28662-28669.
-
(2004)
J Biol Chem
, vol.279
, pp. 28662-28669
-
-
Fu, T.1
Mukhopadhyay, D.2
Davidson, N.O.3
Borensztajn, J.4
-
20
-
-
0034744590
-
PPAR-alpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice
-
Tordjman K, Bernal-Mizrachi C, Zemany L, et al: PPAR-alpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice. J Clin Invest 2001; 107: 1025-1034.
-
(2001)
J Clin Invest
, vol.107
, pp. 1025-1034
-
-
Tordjman, K.1
Bernal-Mizrachi, C.2
Zemany, L.3
-
21
-
-
0029982038
-
Angiographic assessment of effects of bezafibrate on progression of coronary artery disease in young male, postinfarction patients
-
Ericsson CG, Hamsten A, Nilsson J, Grip L, Svane B, de Faire U: Angiographic assessment of effects of bezafibrate on progression of coronary artery disease in young male, postinfarction patients. Lancet 1996; 347: 849-853.
-
(1996)
Lancet
, vol.347
, pp. 849-853
-
-
Ericsson, C.G.1
Hamsten, A.2
Nilsson, J.3
Grip, L.4
Svane, B.5
de Faire, U.6
-
22
-
-
0034604225
-
Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: The Bezafibrate Infarction Prevention (BIP) study
-
Group TBS
-
Group TBS: Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: the Bezafibrate Infarction Prevention (BIP) study. Circulation 2000; 102: 21-27.
-
(2000)
Circulation
, vol.102
, pp. 21-27
-
-
-
23
-
-
0027258140
-
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
-
Ishibashi S, Brown MS, Goldstein JL, Gerard RD, Hammer RE, Herz J: Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 1993; 92: 883-893.
-
(1993)
J Clin Invest
, vol.92
, pp. 883-893
-
-
Ishibashi, S.1
Brown, M.S.2
Goldstein, J.L.3
Gerard, R.D.4
Hammer, R.E.5
Herz, J.6
-
24
-
-
0022003324
-
Variation in susceptibility to atherosclerosis among inbred strains of mice
-
Paigen B, Morrow A, Brandon C, Mitchell D, Holmes P: Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 1985; 57: 65-73.
-
(1985)
Atherosclerosis
, vol.57
, pp. 65-73
-
-
Paigen, B.1
Morrow, A.2
Brandon, C.3
Mitchell, D.4
Holmes, P.5
-
25
-
-
0023634643
-
Quantitative assessment of atherosclerotic lesions in mice
-
Paigen B, Morrow A, Holmes PA, Mitchell D, Williams RA: Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis 1987; 68: 231-240.
-
(1987)
Atherosclerosis
, vol.68
, pp. 231-240
-
-
Paigen, B.1
Morrow, A.2
Holmes, P.A.3
Mitchell, D.4
Williams, R.A.5
-
26
-
-
0034647531
-
Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia
-
Yagyu H, Kitamine T, Osuga J, et al: Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia. J Biol Chem 2000; 275: 21324-21330.
-
(2000)
J Biol Chem
, vol.275
, pp. 21324-21330
-
-
Yagyu, H.1
Kitamine, T.2
Osuga, J.3
-
27
-
-
0036244941
-
A new on-line dual enzymatic method for simultaneous quantification of cholesterol and triglycerides in lipoproteins by HPLC
-
Usui S, Hara Y, Hosaki S, Okazaki M: A new on-line dual enzymatic method for simultaneous quantification of cholesterol and triglycerides in lipoproteins by HPLC. J Lipid Res 2002; 43: 805-814.
-
(2002)
J Lipid Res
, vol.43
, pp. 805-814
-
-
Usui, S.1
Hara, Y.2
Hosaki, S.3
Okazaki, M.4
-
28
-
-
0033391070
-
Streptozotocin-induced diabetes in human apolipoprotein B transgenic mice, Effects on lipoproteins and atherosclerosis
-
Kako Y, Huang LS, Yang J, Katopodis T, Ramakrishnan R, Goldberg IJ: Streptozotocin-induced diabetes in human apolipoprotein B transgenic mice, Effects on lipoproteins and atherosclerosis. J Lipid Res 1999; 40: 2185-2194.
-
(1999)
J Lipid Res
, vol.40
, pp. 2185-2194
-
-
Kako, Y.1
Huang, L.S.2
Yang, J.3
Katopodis, T.4
Ramakrishnan, R.5
Goldberg, I.J.6
-
29
-
-
0033521038
-
An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins
-
van Vlijmen BJ, Rohlmann A, Page ST, et al: An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins. J Biol Chem 1999; 274: 35219-35226.
-
(1999)
J Biol Chem
, vol.274
, pp. 35219-35226
-
-
van Vlijmen, B.J.1
Rohlmann, A.2
Page, S.T.3
-
30
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
-
Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-408.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
31
-
-
0023232216
-
Helsinki Heart Study: Primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease
-
Frick MH, Elo O, Haapa K, et al: Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med 1987; 317: 1237-1245.
-
(1987)
N Engl J Med
, vol.317
, pp. 1237-1245
-
-
Frick, M.H.1
Elo, O.2
Haapa, K.3
-
32
-
-
0033527030
-
Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
-
Rubins HB, Robins SJ, Collins D, et al: Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N Engl J Med 1999; 341: 410-418.
-
(1999)
N Engl J Med
, vol.341
, pp. 410-418
-
-
Rubins, H.B.1
Robins, S.J.2
Collins, D.3
-
33
-
-
28044452217
-
Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): Randomised controlled trial
-
Keech A, Simes RJ, Barter P, et al: Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 2005; 366: 1849-1861.
-
(2005)
Lancet
, vol.366
, pp. 1849-1861
-
-
Keech, A.1
Simes, R.J.2
Barter, P.3
-
34
-
-
0036839889
-
Peroxisome proliferator-activated receptor alpha and gamma agonists upregulate human macrophage lipoprotein lipase expression
-
Li L, Beauchamp MC, Renier G: Peroxisome proliferator-activated receptor alpha and gamma agonists upregulate human macrophage lipoprotein lipase expression. Atherosclerosis 2002; 165: 101-110.
-
(2002)
Atherosclerosis
, vol.165
, pp. 101-110
-
-
Li, L.1
Beauchamp, M.C.2
Renier, G.3
-
35
-
-
0030766476
-
Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice
-
Peters JM, Hennuyer N, Staels B, et al: Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice. J Biol Chem 1997; 272: 27307-27312.
-
(1997)
J Biol Chem
, vol.272
, pp. 27307-27312
-
-
Peters, J.M.1
Hennuyer, N.2
Staels, B.3
-
36
-
-
0036183630
-
The mechanisms of action of PPARs
-
Berger J, Moller DE: The mechanisms of action of PPARs. Annu Rev Med 2002; 53: 409-435.
-
(2002)
Annu Rev Med
, vol.53
, pp. 409-435
-
-
Berger, J.1
Moller, D.E.2
-
37
-
-
0030002205
-
Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase
-
Shimada M, Ishibashi S, Inaba T, et al: Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase. Proc Natl Acad Sci U S A 1996; 93: 7242-7246.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 7242-7246
-
-
Shimada, M.1
Ishibashi, S.2
Inaba, T.3
-
38
-
-
0037462684
-
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis
-
Yamauchi T, Kamon J, Waki H, et al: Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem 2003; 278: 2461-2468.
-
(2003)
J Biol Chem
, vol.278
, pp. 2461-2468
-
-
Yamauchi, T.1
Kamon, J.2
Waki, H.3
-
39
-
-
0037180472
-
Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice
-
Okamoto Y, Kihara S, Ouchi N, et al: Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation 2002; 106: 2767-2770.
-
(2002)
Circulation
, vol.106
, pp. 2767-2770
-
-
Okamoto, Y.1
Kihara, S.2
Ouchi, N.3
-
40
-
-
0034595980
-
Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity
-
Guerre-Millo M, Gervois P, Raspe E, et al: Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem 2000; 275: 16638-16642.
-
(2000)
J Biol Chem
, vol.275
, pp. 16638-16642
-
-
Guerre-Millo, M.1
Gervois, P.2
Raspe, E.3
-
41
-
-
0037649053
-
Bezafibrate improves hypertension and insulin sensitivity in humans
-
Kim JI, Tsujino T, Fujioka Y, Saito K, Yokoyama M: Bezafibrate improves hypertension and insulin sensitivity in humans. Hypertens Res 2003; 26: 307-313.
-
(2003)
Hypertens Res
, vol.26
, pp. 307-313
-
-
Kim, J.I.1
Tsujino, T.2
Fujioka, Y.3
Saito, K.4
Yokoyama, M.5
-
42
-
-
2442660528
-
Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus in patients with coronary artery disease
-
Tenenbaum A, Motro M, Fisman EZ, et al: Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus in patients with coronary artery disease. Circulation 2004; 109; 2197-2202.
-
(2004)
Circulation
, vol.109
, pp. 2197-2202
-
-
Tenenbaum, A.1
Motro, M.2
Fisman, E.Z.3
-
43
-
-
0035138625
-
PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
-
Chinetti G, Lestavel S, Bocher V, et al: PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat Med 2001; 7: 53-58.
-
(2001)
Nat Med
, vol.7
, pp. 53-58
-
-
Chinetti, G.1
Lestavel, S.2
Bocher, V.3
-
44
-
-
0142093152
-
Peroxisome proliferator-activated receptors: New targets for the pharmacological modulation of macrophage gene expression and function
-
Chinetti G, Fruchart JC, Staels B: Peroxisome proliferator-activated receptors: new targets for the pharmacological modulation of macrophage gene expression and function. Curr Opin Lipidol 2003; 14: 459-468.
-
(2003)
Curr Opin Lipidol
, vol.14
, pp. 459-468
-
-
Chinetti, G.1
Fruchart, J.C.2
Staels, B.3
|