Why diabetes patients are more prone to the development of colon cancer?

Medical Hypotheses

Volumn 71, Issue 2, 2008, Pages 241-244

  Jin, Tianru ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON LIKE PEPTIDE 1;

ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; COLON CANCER; DIABETIC PATIENT; DISEASE COURSE; ENDOCRINE CELL; GLUCOSE BLOOD LEVEL; HORMONE SYNTHESIS; HUMAN; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

APOPTOSIS; COLONIC NEOPLASMS; COMORBIDITY; DIABETES COMPLICATIONS; DIABETES MELLITUS; GLUCAGON-LIKE PEPTIDE 1; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; MODELS, BIOLOGICAL; MODELS, THEORETICAL; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 45849134512     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2008.03.025     Document Type: Article

References (37)

1. Chang C.K., and Ulrich C.M. Hyperinsulinaemia and hyperglycaemia: possible risk factors of colorectal cancer among diabetic patients. Diabetologia 46 (2003) 595-607
2. Hu F.B., Manson J.E., Stampfer M.J., Colditz G., Liu S., Solomon C.G., et al. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 345 (2001) 790-797
3. Giovannucci E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr 131 (2001) 3109S-3120S
4. Elwing J.E., Gao F., Davidson N.O., and Early D.S. Type 2 diabetes mellitus: the impact on colorectal adenoma risk in women. Am J Gastroenterol 101 (2006) 1866-1871
5. Tran T.T., Naigamwalla D., Oprescu A.I., Lam L., McKeown-Eyssen G., Bruce W.R., et al. Hyperinsulinemia, but not other factors associated with insulin resistance, acutely enhances colorectal epithelial proliferation in vivo. Endocrinology 147 (2006) 1830-1837
6. Tran T.T., Medline A., and Bruce W.R. Insulin promotion of colon tumors in rats. Cancer Epidemiol Biomarker Prev 5 (1996) 1013-1015
7. Corpet D.E., Jacquinet C., Peiffer G., and Tache S. Insulin injections promote the growth of aberrant crypt foci in the colon of rats. Nutr Cancer 27 (1997) 316-320
8. Koohestani N., Tran T.T., Lee W., Wolever T.M., and Bruce W.R. Insulin resistance and promotion of aberrant crypt foci in the colons of rats on a high-fat diet. Nutr Cancer 29 (1997) 69-76
9. Jemal A., Siegel R., Ward E., Murray T., Xu J., and Thun M.J. Cancer statistics, 2007. CA Cancer J Clin 57 (2007) 43-66
10. Aguilera O, Fraga MF, Ballestar E, Paz MF, Herranz M, Espada J et al. Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Oncogene; 2006.
11. Clements W.M., Lowy A.M., and Groden J. Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors. Clin Colorectal Cancer 3 (2003) 113-120
12. Clevers H. Wnt breakers in colon cancer. Cancer Cell 5 (2004) 5-6
13. Behrens J., von Kries J.P., Kuhl M., Bruhn L., Wedlich D., Grosschedl R., et al. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 382 (1996) 638-642
14. Molenaar M., van de Wetering M., Oosterwegel M., Peterson-Maduro J., Godsave S., Korinek V., et al. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in xenopus embryos. Cell 86 (1996) 391-399
15. He T.C., Sparks A.B., Rago C., Hermeking H., Zawel L., da Costa L.T., et al. Identification of c-MYC as a target of the APC pathway. Science 281 (1998) 1509-1512
16. Tetsu O., and McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398 (1999) 422-426
17. Inoki K., Ouyang H., Zhu T., Lindvall C., Wang Y., Zhang X., et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126 (2006) 955-968
18. Inoki K., Zhu T., and Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115 (2003) 577-590
19. Choo A.Y., Roux P.P., and Blenis J. Mind the GAP: Wnt steps onto the mTORC1 train. Cell 126 (2006) 834-836
20. Desbois-Mouthon C., Cadoret A., Blivet-Van Eggelpoel M.J., Bertrand F., Cherqui G., Perret C., et al. Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation. Oncogene 20 (2001) 252-259
21. Playford M.P., Bicknell D., Bodmer W.F., and Macaulay V.M. Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin. Proc Natl Acad Sci USA 97 (2000) 12103-12108
22. Yang L., Lin C., and Liu Z.R. P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing axin from beta-catenin. Cell 127 (2006) 139-155
23. Holst J.J. Glucagon-like peptide-1: from extract to agent. The Claude Bernard lecture, 2005. Diabetologia 49 (2006) 253-260
24. Drucker D.J. The biology of incretin hormones. Cell Metab 3 (2006) 153-165
25. Vilsboll T., Krarup T., Deacon C.F., Madsbad S., and Holst J.J. Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes 50 (2001) 609-613
26. Holst J.J., and Gromada J. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. Am J Physiol Endocrinol Metab 287 (2004) E199-E206
27. Rask E., Olsson T., Soderberg S., Johnson O., Seckl J., Holst J.J., et al. Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men. Diabetes Care 24 (2001) 1640-1645
28. Fischer K.D., Dhanvantari S., Drucker D.J., and Brubaker P.L. Intestinal growth is associated with elevated levels of glucagon-like peptide 2 in diabetic rats. Am J Physiol 273 (1997) E815-E820
29. Yi F., Sun J., Lim G.E., Fantus I.G., Brubaker P.L., and Jin T. Crosstalk between the insulin and Wnt signaling pathways: Evidence from intestinal endocrine L cells. Endocrinology (2008) in press
30. Chen L., Yan H.X., Chen J., Yang W., Liu Q., Zhai B., et al. Negative regulation of c-Myc transcription by pancreas duodenum homeobox-1. Endocrinology 148 (2007) 2168-2180
31. Laybutt D.R., Weir G.C., Kaneto H., Lebet J., Palmiter R.D., Sharma A., et al. Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes. Diabetes 51 (2002) 1793-1804
32. Pelengaris S., Khan M., and Evan G.I. Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 109 (2002) 321-334
33. Van de Casteele M., Kefas B.A., Cai Y., Heimberg H., Scott D.K., Henquin J.C., et al. Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc. Biochem Biophys Res Commun 312 (2003) 937-944
34. Cano D.A., Rulifson I.C., Heiser P.W., Swigart L.B., Pelengaris S., German M., et al. Regulated-cell regeneration in the adult mouse pancreas. Diabetes (2007)
35. Nieminen A.I., Partanen J.I., and Klefstrom J. c-Myc blazing a trail of death: coupling of the mitochondrial and death receptor apoptosis pathways by c-Myc. Cell Cycle 6 (2007) 2464-2472
36. Boyd K.A., O'Donovan D.G., Doran S., Wishart J., Chapman I.M., Horowitz M., et al. High-fat diet effects on gut motility, hormone, and appetite responses to duodenal lipid in healthy men. Am J Physiol Gastrointest Liver Physiol 284 (2003) G188-G196
37. Sun J., and Jin T. Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells. Cell Signal 20 (2008) 219-229