Early effects of tocilizumab on bone and bone marrow lesions in a collagen-induced arthritis monkey model

Experimental and Molecular Pathology

Volumn 84, Issue 3, 2008, Pages 262-270

  Kato, Atsuhiko ^a   Matsuo, Saori ^a   Takai, Hirotake ^a   Uchiyama, Yasushi ^a   Mihara, Masahiko ^a   Suzuki, Masami ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Collagen induced arthritis model; IL 6; IL 6R; Osteoblast stromal cells; Osteoclasts; RANK; RANKL; Reticulum fibers; Rheumatoid arthritis; Tocilizumab

Indexed keywords

ATLIZUMAB; COLLAGEN; INTERLEUKIN 6; OSTEOCLAST DIFFERENTIATION FACTOR;

ANIMAL MODEL; ARTHRITIS; ARTICLE; BONE MARROW DISEASE; CONTROLLED STUDY; DRUG EFFECT; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MONKEY; NONHUMAN; OSTEOBLAST;

ANIMALS; ANTIBODIES, MONOCLONAL; ARTHRITIS, EXPERIMENTAL; BONE MARROW; FEMALE; INTERLEUKIN-6; MACACA FASCICULARIS; OSTEOCLASTS; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; RECEPTORS, INTERLEUKIN-6;

ANIMALIA; MACACA FASCICULARIS;

EID: 45849120200     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2008.03.003     Document Type: Article

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